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  1. Orthotropic liver transplantation (OLT) offers a therapeutic choice for hepatocellular carcinoma (HCC) patients. The poor outcome of liver transplantation is HCV recurrence. Several genome-wide associated stud...

    Authors: Ghada M. Salum, Mai Abd el Meguid, Tawfeek H. Abelhafez, Eman Medhat, Ashraf O. Abdel Aziz and Reham Dawood
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:174
  2. The era of first green revolution brought about by the application of chemical fertilizers surely led to the explosion of food grains, but left behind the notable problem of salinity. Continuous application of...

    Authors: Mandeep Singh, Usha Nara, Antul Kumar, Anuj Choudhary, Hardeep Singh and Sittal Thapa
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:173
  3. Since the index case was reported in China, COVID-19 has led to the death of at least 4 million people globally. Although there are some vaccine cocktails in circulation, the emergence of more virulent variant...

    Authors: Tolulope Peter Saliu, Haruna I. Umar, Olawale Johnson Ogunsile, Micheal O. Okpara, Noriyuki Yanaka and Olusola Olalekan Elekofehinti
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:172
  4. Biotechnological breeding of elite sugarcane cultivars is currently limited because of the difficulty of regenerating plants by tissue culture. Here, we report that commercially elite sugarcane genotypes, whic...

    Authors: Valentina Di Pauli, Paola Daniela Fontana, Dalia Marcela Lewi, Arturo Felipe and Luis Ernesto Erazzú
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:171
  5. Insulin-like growth factor 2 (IGF2) is one of three hormones that share high structural similarity to insulin. It is involved in several insulin-like growth-regulating and mitogenic activities. This study was con...

    Authors: Dhafer A. Ali, Mohammed Baqur S. Al-Shuhaib, Golzar Farhadi, Fadhil R. Al-Kafajy, Tahreer M. Al-Thuwaini and Ali Esmailizadeh
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:170
  6. Genetic variants in the transcription factor 7-like 2 (TCF7L2) gene are related with type 2 diabetes (T2D) and gestational diabetes mellitus (GDM) in various populations, but there are not enough statistics regar...

    Authors: Taghreed A. Shalabi, Khalda S. Amr and Mai M. Shaker
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:169
  7. The coexistence of cirrhosis complicates the early detection of hepatocellular carcinoma (HCC). Thus, novel biomarkers for HCC early detection are needed urgently. Traditionally, HCC detection is carried out b...

    Authors: Mohamed M. Omran, Sara Mosaad, Tarek M. Emran, Fathy M. Eltaweel and Khaled Farid
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:168
  8. Nitrogen and potassium are crucial supplements for plant development and growth. Plants can detect potassium and nitrate ions in soils and in like way, they modify root-to-shoot transport of these ions to adju...

    Authors: Md. Qamrul Islam, Md. Nazmul Hasan, Hammadul Hoque, Nurnabi Azad Jewel, Md. Fahmid Hossain Bhuiyan and Shamsul H. Prodhan
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:167
  9. Wild medicinal plants are suffering natural environmental stresses and habitat destruction. The genetic diversity evaluation of wild accessions and their in vitro raised genotypes using molecular markers, as w...

    Authors: Abdelfattah Badr, Hanaa H. El-Shazly, Mahmoud Sakr, Mai M. Farid, Marwa Hamouda, Eman Elkhateeb and Hanan Syed Ahmad
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:166
  10. Several vaccines have been fast-tracked in an attempt to decrease the morbidity and mortality of COVID-19. However, post-exposure prophylaxis has been overlooked in battling COVID-19.

    Authors: Antoine AbdelMassih, Rafeef Hozaien, Meryam El Shershaby, Aya Kamel, Habiba-Allah Ismail, Mariem Arsanyous, Nadine El-Husseiny, Noha Khalil, Youstina Naeem and Raghda Fouda
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:165
  11. Serine/threonine kinase 3 (AKT3) is a protein-coding gene that is associated with several cattle immune diseases including different tumors and cancers. The objective of this study was to investigate the differen...

    Authors: Farmanullah Farmanullah, Mostafa Gouda, Zhang Min, Xu Sutong, Mohib Ullah KaKar, Sami Ullah Khan, Muhammad Salim, Momen Khan, Zia ur Rehman, Hira Sajjad Talpur, Faheem Ahmed Khan, Nuruliarizki Shinta Pandupuspitasari and Zhang Shujun
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:164
  12. Pi-ta is a major blast resistant gene, introgressed from indica rice varieties. In this study, diversity of the Pi-ta gene of 47 Sri Lankan rice accessions was studied by bioinformatics, and the results were vali...

    Authors: Suvanthini Terensan, H. Nishadi S. Fernando, J. Nilanthi Silva, S. A. Chandrika N. Perera, Nisha S. Kottearachchi and O. V. D. S. Jagathpriya Weerasena
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:163
  13. The ocean is one of the world’s most important sources of bioactive chemicals in the marine environment. Microbiologists, ecologists, agronomists, taxonomists, and evolutionary biologists have been increasingl...

    Authors: Sahar Saleh Mohamed, Sayeda Abdelrazek Abdelhamid and Radwa Hassaan Ali
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:162
  14. Moscatilin is a bibenzyl derivative (stilbenoid), mainly found in Dendrobium species. This plant-derived chemical is a potential cytotoxic anticancer drug that acts against different cancer types. The present stu...

    Authors: Ipsita Pujari, Ritobrata Sengupta and Vidhu Sankar Babu
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:161
  15. In silico analysis of transcription start sites, promoter regions, transcription factors and their binding sites, and CpG islands for the Trametes hirsuta strain 072 genome were performed to understand the regula...

    Authors: Dinku Senbeta and Mulugeta Kebede
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:160
  16. Chronic kidney Failure (CKD), particularly End-Stage Renal Disease (ESRD), may be serious ill-health related to a high death rate. Uremic syndrome leads to increased oxidative stress, inflammation, and dyslipi...

    Authors: Afaf Elsaid, Omnia Samir eid, Samy B. Said and Rasha F. Zahran
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:158
  17. It remains essential for non-alcoholic fatty liver (NAFLD) patients, to develop a sensitive and specific diagnostic model. Data regarding the use of micro (mi)RNA-34 for NAFLD diagnosis are few. Routine clinic...

    Authors: Amal A. Mohamed, Ahmed El-Demery, Eman Al-Hussain, Shroouk Mousa, Ahmed Abdel Halim, Sahar M. Mostafa, Reda S. Abdelghany, Seham M. Mahmoud, Mohammad A. Elkady, Khaled Raafat, Alshymaa A. Hassnine and Mohamed M. Omran
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:157
  18. Penicillin G amidase/acylases from microbial sources is a unique enzyme that belongs to the N-terminal nucleophilic hydrolase structural superfamily. It catalyzes the selective hydrolysis of side chain amide/a...

    Authors: Krishika Sambyal and Rahul Vikram Singh
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:156
  19. Difficult to express peptides are usually produced by co-expression with fusion partners. In this case, a significant mass part of the recombinant product falls on the subsequently removed fusion partner. On t...

    Authors: Murad Mollaev, Artur Zabolotskii, Neonila Gorokhovets, Elena Nikolskaya, Maria Sokol, Andrey Tsedilin, Mariia Mollaeva, Margarita Chirkina, Timofey Kuvaev, Anna Pshenichnikova and Nikita Yabbarov
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:155
  20. Hepatitis E is a liver disease caused by the pathogen hepatitis E virus (HEV). The largest polyprotein open reading frame 1 (ORF1) contains a nonstructural Y-domain region (YDR) whose activity in HEV adaptatio...

    Authors: Zoya Shafat, Anwar Ahmed, Mohammad K. Parvez and Shama Parveen
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:154
  21. Mastitis is one of the major diseases causing economic loss to the dairy industry by reducing the quantity and quality of milk. Thus, the objective of this scientific study was to find new biomarkers based on ...

    Authors: Farmanullah Farmanullah, Xianwei Liang, Faheem Ahmed Khan, Mohammad Salim, Zia ur Rehman, Momen Khan, Hira Sajjad Talpur, N. M. Schreurs, Mostafa Gouda, Sami Ullah Khan and Zhang Shujun
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:153
  22. Mining for precious metals is detrimental to the composition of soil structure and microbial diversity distribution and is a health risk to human communities around the affected communities. This study was aim...

    Authors: U. B. Ibrahim, A. H. Kawo, I. Yusuf and S. Yahaya
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:152
  23. To develop new breeding technology to improve the breeding ability of bovine, it is the development trend to find the main reason for the occurrence of atresia in these organisms. Transcriptomes of small (100–...

    Authors: Khairy Mohamed Zoheir, Ahmed Mohamed Darwish, Yang Liguo and Abdelkader E. Ashour
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:151
  24. Impact of interleukin 28B (IL28B) rs12979860 polymorphism on response to direct-acting antivirals agents in HCV genotype 4-infected patients is under investigation. Zinc may have an advantage in improvement of li...

    Authors: Abdelfattah M. Attallah, Dalia Omran, Mohamed A. Abdelrazek, Mohamed Hassany, Sameh Saif, Aza Farid, Riham El Essawey, Muhammad Abdel Ghaffar, Marwa Aabdelghany and Ayman Yosry
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:150
  25. Soil pollution by heavy metals increases the bioavailability of metals like hexavalent chromium (Cr (VI)), subsequently limiting plant growth and reducing the efficiency of phytoremediation. Plant growth-promo...

    Authors: Nabil Tirry, Aziza Kouchou, Bouchra El Omari, Mohamed Ferioun and Naïma El Ghachtouli
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:149
  26. Metabolic syndrome is defined as a group of interrelated biochemical, clinical, and metabolic factors that directly increase the risk of cardiovascular disease, obesity, and type 2 diabetes mellitus. MicroRNA-...

    Authors: Miral M. Refeat, Naglaa Abu-Mandil Hassan, Inass Hassan Ahmad, Eman Roshdy Mohamed Mostafa and Khalda S. Amr
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:147
  27. Chromobacterium species, through their bioactive molecules, help in combating biotic and abiotic stresses in plants and humans. The present study was aimed to identify, characterize and preserve in natural gums t...

    Authors: Sushil K. Sharma, Rakhi Dhyani, Ees Ahmad, Pankaj K. Maurya, Madhu Yadav, Ramesh Chandra Yadav, Vinod Kumar Yadav, Pawan K. Sharma, Mahaveer P. Sharma, Aketi Ramesh and Anil K. Saxena
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:146
  28. Potato (Solanum tuberosum L.) is one of the most important food crops in the world. Pathogens remain as one of the major constraints limiting potato productivity. Thus, understanding of gene regulation mechanism ...

    Authors: Atnafu Kebede and Mulugeta Kebede
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:145
  29. Rosa damascena Mill is a well-known species of the rose family. It is famous for its essential oil content. The aim of the present study was to assess the genetic diversity and population structure of a mini core...

    Authors: Atefeh Sadat Mostafavi, Mansour Omidi, Reza Azizinezhad, Alireza Etminan and Hassanali Naghdi Badi
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:144
  30. Hydrolysis of cellulose-based biomass by cellulases produce fermented sugar for making biofuels, such as bioethanol. Cellulases hydrolyze the β-1,4-glycosidic linkage of cellulose and can be obtained from cult...

    Authors: Rahmat Eko Sanjaya, Kartika Dwi Asni Putri, Anita Kurniati, Ali Rohman and Ni Nyoman Tri Puspaningsih
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:143
  31. Mung bean is a pulse crop principally grown in the tropic and subtropic parts of the world for its nutrient-rich seeds. Seven mung beans accessions from Eastern Kenya were evaluated using thirteen phenotypic t...

    Authors: Jedidah Wangari Mwangi, Oduor Richard Okoth, Muchemi Peterson Kariuki and Ngugi Mathew Piero
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:142
  32. Livin/BIRC7 is a member of the inhibitors of apoptosis proteins family which are implicated in development of cancer through the inhibition of apoptosis process. This case-control study was intended to investigat...

    Authors: Basma K. Elmekkawy, Rasha M. S. Shoaib, Amal K. Seleem, Dalia Shaalan and Entsar A. Saad
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:141

    The Correction to this article has been published in Journal of Genetic Engineering and Biotechnology 2022 20:27

  33. Bacterial biofilms are aggregation or collection of different bacterial cells which are covered by self-produced extracellular matrix and are attached to a substratum. Generally, under stress or in unfavorable...

    Authors: Shivani Singh, Saptashwa Datta, Kannan Badri Narayanan and K. Narayanan Rajnish
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:140
  34. Cardiovascular disease (CVD) remains the major cause of death worldwide. Most CVD can be prevented by addressing risk factors. Acute myocardial infarction (AMI) is an inflammatory disorder characterized by cha...

    Authors: Ingy M. Hashad, Habiba Nosseir, Gamal M. Shaban, Mohamed F. Abdel Rahman and Mohamed Z. Gad
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:139
  35. As the body of scientific research focusing on the severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2 continues to grow, several mutations have been reported as very common across the globe. In this...

    Authors: Syeda Tasnim Quayum and Saam Hasan
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:138
  36. This work investigates the production of citric acid from cashew apple juice, an abundant waste in the processing of cashew, using a local strain of Aspergillus niger and the application of the citric acid as a c...

    Authors: Adekunle Olusegun Adeoye and Agbaje Lateef
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:137
  37. The present study reports metagenomic sequencing and microbial diversity analysis of the sediment samples of a semi-intensive penaeid shrimp culture system. 16S rRNA gene-based high-throughput sequencing revea...

    Authors: M. S. Chithira, P. V. Aishwarya, Anjali S. Mohan and Swapna P. Antony
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:136
  38. Protoplasts (i.e., naked plant cells) can be used for in vitro manipulations and genetic improvement in cultivars with economic value. During the last decade, protoplast research in economic brown algae has be...

    Authors: Jose Avila-Peltroche, Boo Yeon Won and Tae Oh Cho
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:135
  39. The recent recovery of Gyrinops walla as a potential producer of market-quality agarwood in mature damaged woods and branches has led to the intense illicit felling and exportation of G. walla leading to the verg...

    Authors: Sachithri Munasinghe, Seneviratnege Somaratne, Shyama Weerakoon and Chandani Ranasinghe
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:134
  40. Amoebiasis, being endemic worldwide, is the second leading cause of parasite-associated morbidity and mortality after malaria. The human parasite Entamoeba histolytica is responsible for the disease. Metronidazol...

    Authors: Suchetana Pal, Pinaki Biswas, Raktim Ghosh and Somasri Dam
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:133
  41. Vitiligo is a common pigmentary disorder in which autoimmunity has been suggested to play an important role. Toll-like receptor (TLR) family are recognized different molecular structures expressed on immune ce...

    Authors: Maha Abdelsalam, Sherihan H. Allam, Marwa Zohdy, Hend Magdy and Maged Mostafa
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:132
  42. The aim of this work was to synthesize copper oxide nanoparticles (CuO NPs) utilizing heartwood aqueous extract of Suaeda maritima (L.) Dumort. The synthesis of CuO NPs using green methodology with small size and...

    Authors: Pavani Peddi, Prasada Rao PTSRK, Nannapaneni Usha Rani and S. Lakshmi Tulasi
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:131
  43. In resource-limited countries, ABO, HLA, MNS, Kells, and hemoglobin electrophoresis are classic tests for the resolution of paternity disputes due to their affordable cost. The limitations of these tests in ca...

    Authors: Missa Millogo, Serge Theophile Soubeiga, Bapio Valerie Jean Telesphore Bazie, Theodora Mahoukede Zohoncon, Abdoul Karim Ouattara, Albert Theophane Yonli and Jacques Simpore
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:130
  44. DNA markers improved the productivity and accuracy of classical plant breeding by means of marker-assisted selection (MAS). The enormous number of quantitative trait loci (QTLs) mapping read for different plan...

    Authors: Nazarul Hasan, Sana Choudhary, Neha Naaz, Nidhi Sharma and Rafiul Amin Laskar
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:128
  45. Tuta absoluta Meyrick 1917 (Lepidoptera: Gelechiidae) is an invasive, pesticide resistant, and a major treat of tomato production in the world. It needs effective management options that naturally infect the inse...

    Authors: Birhan Aynalem, Diriba Muleta, Juan Venegas and Fassil Assefa
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:127
  46. Nanoparticle synthesis is a very interesting area of research currently due to the wide applications of nanoparticles. The nanoparticles have a diameter ranging between 1 and 100 nm and they are used in differ...

    Authors: Deeksha Chugh, V. S. Viswamalya and Bannhi Das
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:126
  47. γ-Aminobutyric acid sub-type A receptors (GABAARs) are the most prominent inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion channel with significant physiological and therape...

    Authors: Amr Ghit, Dina Assal, Ahmed S. Al-Shami and Diaa Eldin E. Hussein
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:123

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