Allford SL, Machin SJ (2007) Haemostasis Surg 25(6):241–244
Google Scholar
Lewis I, Lee S (2007) Physiology of haemopoesis Surg 25(1):3–9
Google Scholar
Shannon M (2007) Anticoagulation Surg 25(4):150–154
Google Scholar
Sharma R, Waller AP, Agrawal S, Wolfgang KJ, Luu H, Shahzad K, Isermann B, Smoyer WE, Nieman MT, Kerlin BA (2017) Thrombin-induced podocyte injury is protease-activated receptor dependent. Am Soc Nephrol 28:2618–2630
Article
Google Scholar
Shirodaria CC, Channon KM (2007) Nitric oxide and vascular disease Surg 25(4):145–149
Google Scholar
Appleby RD, Olds RJ (1997) The inherited basis of venous thrombosis. Pathol 29:341–347
Article
Google Scholar
Mack H, Baucke D, Hornberger W, Lange UEW, Seitzb W, Hoffken HW (2006) Orally active thrombin inhibitors. Part 1: Optimization of the P1-moiety. Bioorg Med Chem Lett 16:2641–2647
Article
Google Scholar
Mihara K, Ramachandran R, Saifeddine M, Hansen KK, Renaux B, Polley D, Gibson S, Vanderboor C, Hollenberg MD (2016) Thrombin-mediated direct activation of proteinase-activated receptor-2: another target for thrombin signaling. Mol Pharmacol 89:606–614
Article
Google Scholar
Licari LG, Kovacic JP (2009) Thrombin physiology and pathophysiology. J Vet Emerg Crit Care 19(1):11–22
Article
Google Scholar
Michaud SE, Wang LZ, Kord N, Buckib R, Randhaw PK, Pastoreb JJ, Falet H, Hoffmeister K, Kuuse R, Uiboc R, Herodd J, Sawyerd E, Janmeya PA (2002) Purification of salmon thrombin and its potential as an alternative to mammalian thrombins in fibrin sealants. Thromb Res 107:245–254
Article
Google Scholar
Tripodi A (2016) Thrombin generation assay and its application in the clinical laboratory. Clin Chem 62(5):699–707
Article
Google Scholar
Wang LZ, Gorlin J, Michaud SE, Janmey PA, Goddeau RP, Kuuse R (2000) Purification of salmon clotting factors and their use as tissue sealants. Thromb Res 100:537–548
Article
Google Scholar
Anand M, Rajagopal K, Rajagopal R (2008) A model for the formation, growth, and lysis of clots in quiescent plasma. A comparison between the effects of antithrombin III deficiency and protein C deficiency. J Theoret Biol 253(4):725–738
Article
MATH
Google Scholar
Colman RW (2001) Contact activation pathway: Inflammatory, fibrinolytic, anticoagulant, antiadhesive and antiangiogenic activities. In: Colman RW, Hirsh J, Marder VJ, Clowes AW, George JN (eds) Hemostasis and Thrombosis: Basic Principles and Clinical Practice. Lippincott Williams and Wilkins, Philadelphia, pp 103–121
Google Scholar
Dahlback B (2000) Blood coagulation. Lancet 355:1627–1632
Article
Google Scholar
Gentry PA (2004) Comparative aspects of blood coagulation. Veterin J 168:238–251
Google Scholar
de Oliveira FM, de Carvalho MVH, Marchi E, Pinto CAL (2016) Collagen, fibrinogen and thrombin biological addesive is effective in treating experimental liver injuries. Rev Col Bras Cir 43(4):254–261
Article
Google Scholar
Gentry PA, Downie HG (1993) Blood coagulation and homeostasis. "Duke s’ Physiology of domestic animals" 11. Cornell University Press, Ithaca, pp 49–63
Google Scholar
Tapparelli C, Metternich R, Ehrhardt C, Cook N (1993) Synthetic low-molecular weight thrombin inhibitors: molecular design and pharmacological profile. Trend Pharmacol Sci 14:366–376
Article
Google Scholar
Ibrahim MA, Masoud HMM (2018) Thrombin inhibitor from the salivary gland of the camel tick Hyalomma dromedarii. Exp Appl Acarol 74:85–97
Article
Google Scholar
Iyer JK, Koh CY, Kazimirova M, Roller L, Jobichen C, Swaminathan K, Mizuguchi J, Iwanaga S, Nuttall PA, Chan MY, Kini RM (2017) Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick. Amblyomma variegatum FASEB J 31(7):2981–2995
Article
Google Scholar
Jablonka W, Kotsyfakis M, Mizurini DM, Monteiro RQ, Lukszo J, Drake SK, Ribeiro JMC, Andersen KF (2015) Identification and mechanistic analysis of a novel tick-derived inhibitor of thrombin. PLoS ONE 10(8):e0133991
Article
Google Scholar
Narasimhan S, Perez O, Mootien S, DePonte K, Koski RA, Fikrig E, Ledizet M (2013) Characterization of ixophilin, a thrombin inhibitor from the gut of ixodes scapularis. PLoS ONE 8(7):e68012
Article
Google Scholar
Brahma RJ, Blanchet G, Kaur S, Kini RM, Doley R (2017) Expression and characterization of haemathrins, madanin-like thrombin inhibitors, isolated from the salivary gland of tick Haemaphysalis bispinosa (Acari: Ixodidae). Thromb res 152:20–29
Article
Google Scholar
Mans BJ, Neitz AW (2004) Adaptation of ticks to a blood-feeding environment: evolution from a functional perspective. Ins Bioch Mol Biol 34:1–17
Article
Google Scholar
Ribeiro JM, Francischetti IM (2003) Role of arthropod saliva in blood feeding: sialome and post-sialome perspectives. Ann Rev Entomol 48:73–88
Article
Google Scholar
Thompson RE, Liu X, Ripoll-Rozada J, Alonso-García N, Parker BL, Pereira PJB, Payne RJ (2017) Tyrosine sulfation modulates activity of tick-derived thrombin inhibitors. Nature Chem 9:909–917
Article
Google Scholar
Koh CY, Shih N, Yip CYC, Li AWL, Chen W, Amran FS, Leong EJE, Iyer JK, Croft G, Bin Mazlan MI, Chee Y, Yap E, Monroe DM, Hoffman M, RCB, de Kleijn DPV, Verma V, Gupta A, Chaudhary VK, Richards AM, Kini RM, Chan MY, (2021) Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors. Nat Commun 12:6912
Article
Google Scholar
Joubert AM, Crause JC, Gaspar AR, Clarke FC, Spickett AM, Neitz AW (1995) Isolation and characterization of an anticoagulant present in the salivary glands of the bont-legged tick, Hyalomma truncatum. Exp Appl Acarol 19:79–92
Article
Google Scholar
Gaspar ARMD, Crause JC, Neitz AWH (1995) Identification of anticoagulant activities in the salivary glands of the soft tick, Ornithodoros savignyi. Exp Appl Acarol 19:117–126
Article
Google Scholar
Ding Z, Xu Y (1995) A rapid simplified purification of bovine thrombin. Prep Biochem 25:21–28
Google Scholar
Ngai PK, Chang JY (1991) A novel one-step purification of human α-thrombin after direct activation of crude prothrombin enriched from plasma. Biochem J 280:805–808
Article
Google Scholar
Smith I (1969) Acrylamide gel disc electrophoresis. In: Smith I (ed) Electrophoretic techniques. Academic Press, New York, pp 365–515
Google Scholar
Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of Bacteriophage T4. Nat 227:680–685
Article
Google Scholar
Weber K, Osborn M (1969) The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. J Biol Chem 244:4406–4412
Article
Google Scholar
Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254
Article
Google Scholar
Barkhordari A, Behzad-Behbahani A, Jajarmi V, Bandehpour M, RafIei-Dehbidi G, Safari F, Mahboudi F (2020) Kazemi1 B (2020) Direct cloning, expression and purifcation of human activated thrombin in prokaryotic system and CD analysis report of produced thrombin: molecular characterization of recombinant thrombin. Int J Pept Res Therap 26:2661–2673
Article
Google Scholar
Bode W, Turk D, Karshikov A (1992) The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships. Prot Sci 1(4):426–471
Article
Google Scholar
Kaetsu H, Mizuguchi J, Hamamoto T, Kamimura K, Yoshida Y, Nakagaki T, Ogata Y, Miyamoto S, Funatsu A (1998) Large-scale preparation of human thrombin: polyethylene glycol potentiates the factor Xa-mediated activation of prothrombin. Thromb Res 90:101–109
Article
Google Scholar
Aizawa P, Winge S, Karlsson G (2008) Large-scale preparation of thrombin from human plasma. Thromb Res 122(4):560–567
Article
Google Scholar
Mann KG, Heldebrant CM, Fass DN (1971) Multiple active forms of thrombin. Mechanism of production from prothrombin. J Biol Chem 246:6106–6114
Article
Google Scholar
Ibrahim MA, Ghazy AM, Maharem T, Khalil M (2001) Isolation and properties of two forms of thrombin inhibitor from the nymphs of the camel tick Hyalomma dromedarii (Acari: Ixodidae). Exp Appl Acarol 25:675–698
Article
Google Scholar
Nienaber J, Gaspar AR, Neitz AW (1999) Savignin, a potent thrombin inhibitor isolated from the salivary glands of the tick Ornithodoros savignyi (Acari: Argasidae). Exp Parasitol 93:82–91
Article
Google Scholar
Zhu K, Bowman AS, Brigham DL, Essenberg RC, Dillwith JW, Sauer JR (1997) Isolation and characterization of americanin, a specific inhibitor of thrombin, from the salivary glands of the lone star tick Amblyomma americanum (L.). Exp Parasit 87:30–38
Article
Google Scholar
Lopez M, Mende K, Steinmetzer T, Nowak G (2003) Cloning, purification and biochemical characterization of dipetarudin, a new chimeric thrombin inhibitor. J Chromat B 786:73–80
Article
Google Scholar
Lopez M, Koehler A, Nowak G (2007) High level secretion of dipetarudin, a chimeric thrombin inhibitor by Pichia pastoris. Prot Expr Pur 52:8–13
Article
Google Scholar