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  1. This study targets the enhanced production of l-asparaginase, an antitumor enzyme by Acinetobacter baumannii ZAS1. This organism is an endophyte isolated from the medicinal plant Annona muricata. Plackett–Burman ...

    Authors: K. N. Abhini, Akhila B. Rajan, K. Fathimathu Zuhara and Denoj Sebastian
    Citation: Journal of Genetic Engineering and Biotechnology 2022 20:22
  2. Wadi El Natrun microorganisms have been considered as a new resource for natural products due to its extreme condition of salinity and alkalinity. Therefore, this study was devoted to generate metagemic librar...

    Authors: Safaa M. Ali, Nadia A. Soliman, Samia Abd Allah Abdal-Aziz and Yasser R. Abdel-Fattah
    Citation: Journal of Genetic Engineering and Biotechnology 2022 20:20
  3. A major discovery in human etiology recognized that cervical cancer is a consequence of an infection caused by some mucosatropic types of human papillomavirus (HPV). Since L1 protein of HPV is able to induce t...

    Authors: Apon Zaenal Mustopa, Lita Meilina, Shasmita Irawan, Nurlaili Ekawati, Alfi Taufik Fathurahman, Lita Triratna, Arizah Kusumawati, Anika Prastyowati, Maritsa Nurfatwa, Ai Hertati and Rikno Harmoko
    Citation: Journal of Genetic Engineering and Biotechnology 2022 20:19
  4. The primary amino acid sequence of a protein is a translated version from its gene sequence which carries important messages and information concealed therein. The present study unveils the structure-function ...

    Authors: Krishnendu Pramanik and Narayan Chandra Mandal
    Citation: Journal of Genetic Engineering and Biotechnology 2022 20:18
  5. Diabetic retinopathy (DR) is a common microvascular complication of diabetes. There is strong evidence suggesting that DR has an inheritable component. The interaction between advanced glycation end products (...

    Authors: Pragya Ahuja, Abdul Waris, Sheelu Shafiq Siddiqui and Amit Mukherjee
    Citation: Journal of Genetic Engineering and Biotechnology 2022 20:17
  6. Castor bean (Ricinus communis L.) is an important cultivated oilseed. Seeds contain ricinoleic acid, a valuable product for a variety of industries. Castor cake is a residue of ricinoleic manufacture and could be...

    Authors: Natália L. de Sousa, Glaucia B. Cabral and Francisco J. L. Aragão
    Citation: Journal of Genetic Engineering and Biotechnology 2022 20:16
  7. Mitochondrial complex ΙΙ has a unique biological role owing to its participation in both the citric acid cycle and the electron transport chain. Our goal was to evaluate the succinate dehydrogenase and ubiquin...

    Authors: Eman M. Ragab, Doaa M. El Gamal, Tarek M. Mohamed and Abeer A. Khamis
    Citation: Journal of Genetic Engineering and Biotechnology 2022 20:15
  8. The marine environment hosts a wide variety of species that have evolved to live in harsh and challenging conditions. Marine organisms are the focus of interest due to their capacity to produce biotechnologica...

    Authors: Akash Karthikeyan, Abey Joseph and Baiju G. Nair
    Citation: Journal of Genetic Engineering and Biotechnology 2022 20:14
  9. Association between Helicobacter pylori (H. pylori) and chronic hepatitis C (CHC) still remains controversial. This work is concerned with assessing the potential role of H. pylori in the progression of hepatitis...

    Authors: Abdelfattah M. Attallah, Mohamed S. Albannan, Mohamed F. Ghaly, Sally E. Sallam, Mahmoud M. Amer and Attia A. Attia
    Citation: Journal of Genetic Engineering and Biotechnology 2022 20:13
  10. Although microbial fuel cells (MFCs) represent a promising technology for capturing renewable energy from wastewater, their scaling-up is significantly limited by a slow-rate cathodic oxygen reduction reaction...

    Authors: Dena Z. Khater, R. S. Amin, M. O. Zhran, Zeinab K. Abd El-Aziz, Mohamed Mahmoud, Helmy M. Hassan and K. M. El-Khatib
    Citation: Journal of Genetic Engineering and Biotechnology 2022 20:12
  11. Essential hypertension (EH) is an important risk factor for various cardiovascular, cerebral and renal disorders. It is a multi-factorial trait which occurs through complex interplay between genetic, epigeneti...

    Authors: Mayank Chaudhary
    Citation: Journal of Genetic Engineering and Biotechnology 2022 20:11
  12. Phytochromes are the best characterized photoreceptors that perceive Red (R)/Far-Red (FR) signals and mediate key developmental responses in plants. It is well established that photoperiodic control of floweri...

    Authors: Stuti Krishna, Kaushal Modha, Vipulkumar Parekh, Ritesh Patel and Digvijay Chauhan
    Citation: Journal of Genetic Engineering and Biotechnology 2022 20:9
  13. Myelin basic protein (MBP) is one of the most important structural components of the myelin sheaths in both central and peripheral nervous systems. MBP has several functions including organization of the myeli...

    Authors: Juan Sebastian Cruz-Méndez, María Paula Herrera-Sánchez, Ángel Enrique Céspedes-Rubio and Iang Schroniltgen Rondón-Barragán
    Citation: Journal of Genetic Engineering and Biotechnology 2022 20:8
  14. Tumor necrosis factor alpha (TNFA) is an important cytokine that influences multiple biological processes. It is one of the key mediators of acute and chronic systemic inflammatory reactions and plays a centra...

    Authors: Tamim Ahsan and Abu Ashfaqur Sajib
    Citation: Journal of Genetic Engineering and Biotechnology 2022 20:7
  15. An amendment to this paper has been published and can be accessed via the original article.

    Authors: K. H. T. Karunarathna, N. H. K. S. Senathilake, K. M. Mewan, O. V. D. S. J. Weerasena and S. A. C. N. Perera
    Citation: Journal of Genetic Engineering and Biotechnology 2022 20:6

    The original article was published in Journal of Genetic Engineering and Biotechnology 2020 18:32

  16. Silver nanoparticles (AgNPs) are the most widely used nanomaterial in agricultural and environmental applications. In this study, the impact of AgNPs solutions at 20 mg/L, 40 mg/L, 80 mg/L, and 160 mg/L on cel...

    Authors: May Labeeb, Abdelfattah Badr, Soliman A. Haroun, Magdy Z. Mattar and Aziza S. El-kholy
    Citation: Journal of Genetic Engineering and Biotechnology 2022 20:5
  17. Hepatocellular carcinoma (HCC) is considered one of the most common cancers related to mortality around the world, and susceptibility is related with genetic, lifestyle, and environmental factors. Copy number ...

    Authors: Eman Abd El Razek Abbas, Ahmed Barakat Barakat, Mohamed Hassany and Samar Samir Youssef
    Citation: Journal of Genetic Engineering and Biotechnology 2022 20:4
  18. Guava fruit softening is a crucial process during ripening and this process involves a number of enzymes that modifies the cell wall. Two of the enzymes that regulate this process are (a) the β-1, 4-endoglucan...

    Authors: Mario A. Mejía-Mendoza, Cristina Garcidueñas-Piña, José S. Padilla-Ramírez, Ruth E. Soria-Guerra and José Francisco Morales-Domínguez
    Citation: Journal of Genetic Engineering and Biotechnology 2022 20:3
  19. Lignin is a complex polymer of phenyl propanoid units found in the vascular tissues of the plants as one of lignocellulose materials. Many bacteria secrete enzymes to lyse lignin, which can be essential to eas...

    Authors: Subhashree Rath, Manish Paul, Hemanta Kumar Behera and Hrudayanath Thatoi
    Citation: Journal of Genetic Engineering and Biotechnology 2022 20:2
  20. In the present study, adaptive laboratory evolution was used to stimulate antibiotic production in a Streptomyces strain JB140 (wild-type) exhibiting very little antimicrobial activity against bacterial pathogens...

    Authors: Dharmesh Harwani, Jyotsna Begani, Sweta Barupal and Jyoti Lakhani
    Citation: Journal of Genetic Engineering and Biotechnology 2022 20:1
  21. Autoinflammatory disorders are the group of inherited inflammatory disorders caused due to the genetic defect in the genes that regulates innate immune systems. These have been clinically characterized based o...

    Authors: Abhinav Jain, Rahul C. Bhoyar, Kavita Pandhare, Anushree Mishra, Disha Sharma, Mohamed Imran, Vigneshwar Senthivel, Mohit Kumar Divakar, Mercy Rophina, Bani Jolly, Arushi Batra, Sumit Sharma, Sanjay Siwach, Arun G. Jadhao, Nikhil V. Palande, Ganga Nath Jha…
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:183
  22. Many species of mushroom contain an assortment of free radical scavengers (Phenolics and Flavonoids compounds) that have made them nutritionally beneficial and a source of expansion of drug production. In this...

    Authors: Amal I. Hassan, Mona A. M. Ghoneim, Manal G. Mahmoud and Mohsen S. Asker
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:182
  23. The Pehuén or Monkey puzzle tree (Araucaria araucana) is an evergreen coniferous tree, which has been historically used for social, medicinal, and nutritional purposes. We have recently showed the value of A. ara...

    Authors: María C. Gallia, Julieta Echeverri Del Sarto and Guillermina A. Bongiovanni
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:181
  24. Despite a reduction in global HIV prevalence the development of a pipeline of new therapeutics or pre-exposure prophylaxis to control the HIV/AIDS epidemic are of high priority. Antibody-based therapies offer ...

    Authors: Advaita Acarya Singh, Priyen Pillay, Lusisizwe Kwezi and Tsepo Lebiletsa Tsekoa
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:180
  25. Various bacteria promote plant root growth in the rhizosphere, as a measure of securing and enlarging their ecological niche. These interactions are mediated by plant growth regulators (PGRs) such as auxin, an...

    Authors: Seunghye Park, A-Leum Kim, Yoon-Kyung Hong, Ji-Hwan Shin and Se-Hwan Joo
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:179
  26. Finger millet is the most important food grain in the world for its nutritional benefits. Finger millet is genetically and geographically diverse and widely spread in the African and Asian sub-continent. There...

    Authors: Jayalakshmi Venkatesan, Vasuki Ramu, Thilaga Sethuraman, Chandrasekaran Sivagnanam and Ganesh Doss
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:178
  27. Leaf senescence occurs in an age-dependent manner, but the rate and timing of leaf senescence may be influenced by various biotic and abiotic factors. In the course of stress, the function, composition, and di...

    Authors: Shamsu Ado Zakari, Syed Hassan Raza Zaidi, Mustapha Sunusi and Kabiru Dawaki Dauda
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:177
  28. Polycystic ovary syndrome (PCOS) is a chronic endocrine disorder prevalent in premenopausal women and is characterized by a range of physiological and biochemical abnormalities which may include reproductive, ...

    Authors: Fehintoluwa Joy Femi-Olabisi, Ahmed Adebayo Ishola, Opeyemi Faokunla, Anthonia Oluyemi Agboola and Benjamin Ayodipupo Babalola
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:176
  29. Gerbera jamesonii Bolus ex Hooker f. (African daisy) is listed among the top five most important ornamental plants in the global floricultural industry. To satisfy its demand, the floriculture industry relies on...

    Authors: Saikat Gantait and Manisha Mahanta
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:175
  30. Orthotropic liver transplantation (OLT) offers a therapeutic choice for hepatocellular carcinoma (HCC) patients. The poor outcome of liver transplantation is HCV recurrence. Several genome-wide associated stud...

    Authors: Ghada M. Salum, Mai Abd el Meguid, Tawfeek H. Abelhafez, Eman Medhat, Ashraf O. Abdel Aziz and Reham Dawood
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:174
  31. The era of first green revolution brought about by the application of chemical fertilizers surely led to the explosion of food grains, but left behind the notable problem of salinity. Continuous application of...

    Authors: Mandeep Singh, Usha Nara, Antul Kumar, Anuj Choudhary, Hardeep Singh and Sittal Thapa
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:173
  32. Since the index case was reported in China, COVID-19 has led to the death of at least 4 million people globally. Although there are some vaccine cocktails in circulation, the emergence of more virulent variant...

    Authors: Tolulope Peter Saliu, Haruna I. Umar, Olawale Johnson Ogunsile, Micheal O. Okpara, Noriyuki Yanaka and Olusola Olalekan Elekofehinti
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:172
  33. Biotechnological breeding of elite sugarcane cultivars is currently limited because of the difficulty of regenerating plants by tissue culture. Here, we report that commercially elite sugarcane genotypes, whic...

    Authors: Valentina Di Pauli, Paola Daniela Fontana, Dalia Marcela Lewi, Arturo Felipe and Luis Ernesto Erazzú
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:171
  34. Insulin-like growth factor 2 (IGF2) is one of three hormones that share high structural similarity to insulin. It is involved in several insulin-like growth-regulating and mitogenic activities. This study was con...

    Authors: Dhafer A. Ali, Mohammed Baqur S. Al-Shuhaib, Golzar Farhadi, Fadhil R. Al-Kafajy, Tahreer M. Al-Thuwaini and Ali Esmailizadeh
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:170
  35. Genetic variants in the transcription factor 7-like 2 (TCF7L2) gene are related with type 2 diabetes (T2D) and gestational diabetes mellitus (GDM) in various populations, but there are not enough statistics regar...

    Authors: Taghreed A. Shalabi, Khalda S. Amr and Mai M. Shaker
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:169
  36. The coexistence of cirrhosis complicates the early detection of hepatocellular carcinoma (HCC). Thus, novel biomarkers for HCC early detection are needed urgently. Traditionally, HCC detection is carried out b...

    Authors: Mohamed M. Omran, Sara Mosaad, Tarek M. Emran, Fathy M. Eltaweel and Khaled Farid
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:168
  37. Nitrogen and potassium are crucial supplements for plant development and growth. Plants can detect potassium and nitrate ions in soils and in like way, they modify root-to-shoot transport of these ions to adju...

    Authors: Md. Qamrul Islam, Md. Nazmul Hasan, Hammadul Hoque, Nurnabi Azad Jewel, Md. Fahmid Hossain Bhuiyan and Shamsul H. Prodhan
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:167
  38. Wild medicinal plants are suffering natural environmental stresses and habitat destruction. The genetic diversity evaluation of wild accessions and their in vitro raised genotypes using molecular markers, as w...

    Authors: Abdelfattah Badr, Hanaa H. El-Shazly, Mahmoud Sakr, Mai M. Farid, Marwa Hamouda, Eman Elkhateeb and Hanan Syed Ahmad
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:166
  39. Several vaccines have been fast-tracked in an attempt to decrease the morbidity and mortality of COVID-19. However, post-exposure prophylaxis has been overlooked in battling COVID-19.

    Authors: Antoine AbdelMassih, Rafeef Hozaien, Meryam El Shershaby, Aya Kamel, Habiba-Allah Ismail, Mariem Arsanyous, Nadine El-Husseiny, Noha Khalil, Youstina Naeem and Raghda Fouda
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:165
  40. Serine/threonine kinase 3 (AKT3) is a protein-coding gene that is associated with several cattle immune diseases including different tumors and cancers. The objective of this study was to investigate the differen...

    Authors: Farmanullah Farmanullah, Mostafa Gouda, Zhang Min, Xu Sutong, Mohib Ullah KaKar, Sami Ullah Khan, Muhammad Salim, Momen Khan, Zia ur Rehman, Hira Sajjad Talpur, Faheem Ahmed Khan, Nuruliarizki Shinta Pandupuspitasari and Zhang Shujun
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:164
  41. Pi-ta is a major blast resistant gene, introgressed from indica rice varieties. In this study, diversity of the Pi-ta gene of 47 Sri Lankan rice accessions was studied by bioinformatics, and the results were vali...

    Authors: Suvanthini Terensan, H. Nishadi S. Fernando, J. Nilanthi Silva, S. A. Chandrika N. Perera, Nisha S. Kottearachchi and O. V. D. S. Jagathpriya Weerasena
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:163
  42. The ocean is one of the world’s most important sources of bioactive chemicals in the marine environment. Microbiologists, ecologists, agronomists, taxonomists, and evolutionary biologists have been increasingl...

    Authors: Sahar Saleh Mohamed, Sayeda Abdelrazek Abdelhamid and Radwa Hassaan Ali
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:162
  43. Moscatilin is a bibenzyl derivative (stilbenoid), mainly found in Dendrobium species. This plant-derived chemical is a potential cytotoxic anticancer drug that acts against different cancer types. The present stu...

    Authors: Ipsita Pujari, Ritobrata Sengupta and Vidhu Sankar Babu
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:161
  44. In silico analysis of transcription start sites, promoter regions, transcription factors and their binding sites, and CpG islands for the Trametes hirsuta strain 072 genome were performed to understand the regula...

    Authors: Dinku Senbeta and Mulugeta Kebede
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:160
  45. Chronic kidney Failure (CKD), particularly End-Stage Renal Disease (ESRD), may be serious ill-health related to a high death rate. Uremic syndrome leads to increased oxidative stress, inflammation, and dyslipi...

    Authors: Afaf Elsaid, Omnia Samir eid, Samy B. Said and Rasha F. Zahran
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:158
  46. It remains essential for non-alcoholic fatty liver (NAFLD) patients, to develop a sensitive and specific diagnostic model. Data regarding the use of micro (mi)RNA-34 for NAFLD diagnosis are few. Routine clinic...

    Authors: Amal A. Mohamed, Ahmed El-Demery, Eman Al-Hussain, Shroouk Mousa, Ahmed Abdel Halim, Sahar M. Mostafa, Reda S. Abdelghany, Seham M. Mahmoud, Mohammad A. Elkady, Khaled Raafat, Alshymaa A. Hassnine and Mohamed M. Omran
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:157
  47. Penicillin G amidase/acylases from microbial sources is a unique enzyme that belongs to the N-terminal nucleophilic hydrolase structural superfamily. It catalyzes the selective hydrolysis of side chain amide/a...

    Authors: Krishika Sambyal and Rahul Vikram Singh
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:156
  48. Difficult to express peptides are usually produced by co-expression with fusion partners. In this case, a significant mass part of the recombinant product falls on the subsequently removed fusion partner. On t...

    Authors: Murad Mollaev, Artur Zabolotskii, Neonila Gorokhovets, Elena Nikolskaya, Maria Sokol, Andrey Tsedilin, Mariia Mollaeva, Margarita Chirkina, Timofey Kuvaev, Anna Pshenichnikova and Nikita Yabbarov
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:155

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