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  1. Genome of an organism has always fascinated life scientists. With the discovery of restriction endonucleases, scientists were able to make targeted manipulations (knockouts) in any gene sequence of any organis...

    Authors: Anuradha Bhardwaj and Vikrant Nain
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:125
  2. Phospholipases hydrolyze glycerophospholipids and generate diverse lipid-derived molecules with secondary messenger activity. Out of these, phospholipase C (PLC) specifically cleaves the phospholipids at ester...

    Authors: Madhvi Kanchan, Thakku R. Ramkumar, Himani and Jaspreet K. Sembi
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:124
  3. γ-Aminobutyric acid sub-type A receptors (GABAARs) are the most prominent inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion channel with significant physiological and therape...

    Authors: Amr Ghit, Dina Assal, Ahmed S. Al-Shami and Diaa Eldin E. Hussein
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:123
  4. Terrestrial orchids belonging to the Orchis genus are difficult to propagate and are under great pressure in their natural habitats. Studies regarding the influence of photoperiod and temperature regimes on Orchi...

    Authors: Aleksandra Yurievna Nabieva
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:122
  5. Canine circovirus is a deadly pathogen of dogs and causes vasculitis and hemorrhagic enteritis. It causes lethal gastroenteritis in pigs, fox, and dogs. Canine circovirus genome contains two main (and opposite) t...

    Authors: Pankaj Jain, Amit Joshi, Nahid Akhtar, Sunil Krishnan and Vikas Kaushik
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:121
  6. The present study dealt with the screening of soil bacteria with antibacterial activity from different locations in Bangalore, India. Antibiotics play the role of self-defense mechanism for the bacteria and ar...

    Authors: R. Prashanthi, Shreevatsa G.K., Krupalini S. and Manoj L.
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:120
  7. Sandwich ELISA is an ideal antigen detection and quantification assay. Recently, it was used as the basic concept for high technology diagnostics. The specificity of the assay depends on the exclusion of detec...

    Authors: Rola Nadeem, Ahmed B. Barakat and Mahmoud M. Bahgat
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:119
  8. Illicium griffithii is an aromatic medicinal tree species that has been listed in the IUCN Red List as an endangered species. Dried seed pods of I. griffithii have a good market potential in the spices and pharma...

    Authors: Rajib Borah, Atanu Bhattacharjee, Satyawada Rama Rao, Vineet Kumar, Pradeep Sharma, Krishna Upadhaya and Hiranjit Choudhury
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:118
  9. Oleuropein, the main bitter phenolic glucoside responsible for green olive bitterness, may be degraded by the β-glucosidase enzyme to release glucose and phenolic compounds.

    Authors: Yahya Rokni, Houssam Abouloifa, Reda Bellaouchi, Ismail Hasnaoui, Sara Gaamouche, Zahra Lamzira, Riadh B. E. N. Salah, Ennouamane Saalaoui, Nabil Ghabbour and Abdeslam Asehraou
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:117
  10. Ovarian cancer causes more deaths than any other cancer of the female reproductive system because there is no effective screening and most women are diagnosed at advanced stages. The probability of survival at...

    Authors: J. N. Nikhitha, K. S. Swathy and R. Pratap Chandran
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:116
  11. Vitamin D receptor (VDR) is known as one of the cellular regulators for several metabolic pathways indicating its pivotal role in the pathological pathway of numerous diseases. Considering the high frequency o...

    Authors: Nayera E. Hassan, Sahar A. El-Masry, Waheba Ahmed Zarouk, Ghada Nour Eldeen, Rehab M. Mosaad, Mahmoud A. S. Afify, Manal M. Aly and Aya Khalil
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:115
  12. The health-promoting effects along with global economic importance of consuming food products supplemented with probiotic microorganisms encouraged the researchers to discover new probiotics.

    Authors: Al-Shimaa Ibrahim Ahmed, Gihan Mohamed El Moghazy, Tarek Ragab Elsayed, Hanan Abdel Latif Goda and Galal Mahmoud Khalafalla
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:114
  13. Targeting viral cell entry proteins is an emerging therapeutic strategy for inhibiting the first stage of SARS-CoV-2 infection. In this study, 106 bioactive terpenoids from African medicinal plants were screen...

    Authors: Gideon A. Gyebi, Oludare M. Ogunyemi, Ibrahim M. Ibrahim, Olalekan B. Ogunro, Adegbenro P. Adegunloye and Saheed O. Afolabi
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:113
  14. Variants in the signal transducer and activator of transcription 4 (STAT4) gene have an important role in the incident of multiple autoimmune diseases including type 1 diabetes mellitus (T1D). It is a genetica...

    Authors: Samar Samir Abdelmajed, Mohamed A. El-Dessouky, Doaa S. SalahElDin, Naglaa Abu-Mandil Hassan, Moushira Erfan Zaki and Somaia Ismail
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:112
  15. Mucolipidosis II (ML II α/β) is an inherited lysosomal storage disorder caused by deficiency of GlcNAc-phosphotransferase enzyme and results in mis-targeting of multiple lysosomal enzymes. Affected patients ar...

    Authors: Mona L. Essawi, Ekram M. Fateen, Hanan A. Atia, Noura R. Eissa, Eman H. Aboul-Ezz, Mona M. Ibrahim, Heba A. Hassan and Samia A. Temtamy
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:111
  16. Pullulanases are the significant industrial group in the 13 glycosyl hydrolases category, known as the α-amylases family. There are very few reports on pullulanase from fungal sources. Based on the above resea...

    Authors: Bindu Naik, S. K. Goyal, Abhishek Dutt Tripathi and Vijay Kumar
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:110
  17. Insulin-like growth factor-1 (IGF-1) is required for normal intrauterine and postnatal growth, and this action is mediated through IGF1 receptor (IGF1R). IGF1R copy number variants (CNVs) can cause pre- and postn...

    Authors: Islam M. Fadel, Moustafa H. Ragab, Ola M. Eid, Nivine A. Helmy, Hala T. El-Bassyouni and Inas Mazen
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:109
  18. Anarrhinum pubescens Fresen. (Plantaginaceae) is a rare plant, endemic to the Saint Catherine area, of South Sinai, Egypt. Earlier studies have reported the isolation of cytotoxic and anti-cholinesterase iridoid ...

    Authors: Asmaa Abdelsalam, Ehab Mahran, Kamal Chowdhury and Arezue Boroujerdi
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:108
  19. Argentina’s geothermal areas are niches of a rich microbial diversity. In 2020, species of Bacillus cytotoxicus were isolated for the first time from these types of pristine natural areas. Bacillus cytotoxicus st...

    Authors: Ivana Cavello, Brenda Bezus and Sebastián Cavalitto
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:107
  20. The discovery of potential, new cost-effective drug resources in the form of bioactive compounds from mushrooms is one way to control the resistant pathogens. In the present research, the fruiting bodies of fi...

    Authors: Elham R. S. Soliman and Heba El-Sayed
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:106
  21. Cardiovascular diseases (CVDs) are the leading cause of mortality in India. Residual risk exists in patients receiving optimal guideline-directed medical therapy. Possession of certain somatic mutations, at a ...

    Authors: Nagendra Boopathy Senguttuvan, Vinodhini Subramanian, Vettriselvi Venkatesan, T. R. Muralidharan and Kavitha Sankaranarayanan
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:105
  22. Accessing COVID-19 vaccines is a challenge despite successful clinical trials. This burdens the COVID-19 treatment gap, thereby requiring accelerated discovery of anti-SARS-CoV-2 agents. This study explored th...

    Authors: Von Novi O. de Leon, Joe Anthony H. Manzano, Delfin Yñigo H. Pilapil IV, Rey Arturo T. Fernandez, James Kyle Anthony R. Ching, Mark Tristan J. Quimque, Jay Carl M. Agbay, Kin Israel R. Notarte and Allan Patrick G. Macabeo
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:104
  23. Plasmodium falciparum is the most deadly and leading cause of morbidity and mortality in Africa. About 90% of all malaria deaths in the world today occur in Sub-Saharan Africa especially in children aged < 5 year...

    Authors: Claire Aguttu, Brenda Apio Okech, Ambrose Mukisa and George William Lubega
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:103
  24. Actinomycetes associated with marine sponge represent a promising source of bioactive compounds. Herein, we report the isolation, identification, and bioactivity evaluation of Streptomyces sp. NMF6 associated wit...

    Authors: Nayer Mohamed Fahmy and Asmaa Mohamed Abdel-Tawab
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:102
  25. The SARS-CoV-2 belongs to Coronaviridae family infects host cells by the interaction of its spike glycoprotein and angiotensin-converting enzyme 2 (ACE 2) of host cells. Upon entry, the virus uses its RNA depe...

    Authors: Lokanathan Srikanth and Potukuchi Venkata Gurunadha Krishna Sarma
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:101
  26. Hypoxia refers to the condition of low oxygen pressure in the atmosphere and characterization of response to hypoxia as a biological complex puzzle, is challenging. Previously, we carried out a comparative gen...

    Authors: Hamed Kharrati-Koopaee, Esmaeil Ebrahimie, Mohammad Dadpasand, Ali Niazi, Rugang Tian and Ali Esmailizadeh
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:100
  27. Soil salinity has been one of the biggest hurdles in achieving better crop yield and quality. Plant growth-promoting rhizobacteria (PGPR) are the symbiotic heterogeneous bacteria that play an important role in...

    Authors: Arti Sharma, Kamal Dev, Anuradha Sourirajan and Madhu Choudhary
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:99
  28. Chronic lymphocytic leukemia (CLL) is the most common form of adult leukemia. This disease is genetically heterogeneous, and approximately 85% of patients with CLL harbor chromosomal aberrations that are consi...

    Authors: Ola M. Eid, Rania M. A. Abdel Kader, Lamiaa A. Fathalla, Amany H. Abdelrahman, Ahmed Rabea, Rana Mahrous and Maha M. Eid
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:98
  29. Plant-associated microbes (endophytes) have a significant relationship to enhance plant growth and crop productivity by producing proficient bioactive metabolites. Since endophytes promoted plant growth either...

    Authors: Mustafa Elsayed Abd Elsallam, Shahira Hussainy EL-Moslamy, Ahmed Abd El-Al and Hoda Farouk Zahran
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:97
  30. In crop plants, to cope up with the demand of food for rising population, revolutionary crop improvement programmes are being implemented for higher and higher yields. Abiotic stress, especially at flowering s...

    Authors: Sridevi Muppala, Pavan Kumar Gudlavalleti, Kodandarami Reddy Malireddy, Sateesh Kumar Puligundla and Premalatha Dasari
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:96
  31. Drug response is below genetic influence, proven by the genetic variants. Pharmacogenetics trials are performed in many diseases, including coronary artery disease. This study was designed to determine the gen...

    Authors: Shaimaa Y. Abdulfattah and Salwa J. Al-Awadi
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:95
  32. Pest control strategies almost entirely rely on chemical insecticides, which cause environmental problems such as biosphere deterioration and emergence of resistant pests. Bio-pesticide is an alternative appro...

    Authors: Getachew Bantihun and Mulugeta Kebede
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:94
  33. Jewel orchid is the common name of several orchid species which can be alike in morphological characteristics, but variable in medicinal properties. At present, two DNA barcode loci, namely, maturase K (matK) and...

    Authors: Viet The Ho, Thi Kim Phuong Tran, Thi Thanh Tram Vu and Sasanti Widiarsih
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:93
  34. Candida albicans is an opportunistic human fungal pathogen responsible for superficial and systemic life-threatening infections. Treating these infections is challenging as many clinical isolates show increased d...

    Authors: Wasim Uddin, Darshan Dhabalia, S. M. Udaya Prakash and M. Anaul Kabir
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:92
  35. Bladder cancer is considered heterogeneous diseases with two major subgroups: non-muscle- invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC). It is a major healthcare problem, and it is ...

    Authors: Mohamed K. Khalifa, Noha M. Bakr, Amal Ramadan, Khaled M. Abd Elwahab, Esam Desoky, Amira M. Nageeb and Menha Swellam
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:91
  36. Whilst traditional strategies to increase transfection efficiency of non-viral systems aimed at modifying the vector or the polyplexes/lipoplexes, biomaterial-mediated gene delivery has recently sparked increa...

    Authors: Valeria Graceffa
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:90
  37. Cockayne syndrome (CS), which was discovered by Alfred Cockayne nearly 75 years ago, is a rare autosomal recessive disorder characterized by growth failure, neurological dysfunction, premature aging, and other...

    Authors: Amr Ghit
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:88
  38. Microbial community is one of the diversified communities of the marine environment. Studies have shown that microorganisms isolated from the marine environment are metabolically active and have adapted to lif...

    Authors: Teja Mandragutti, Muni Kumar Dokka, Bindiya Panchagnula and Sudhakar Godi
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:87
  39. Genome editing employing the CRISPR/Cas9 system has been widely used and has become a promising tool for plant gene functional studies and crop improvement. However, most of the applied CRISPR/Cas9 systems tar...

    Authors: Bohari Bahariah, Mat Yunus Abdul Masani, Omar Abd Rasid and Ghulam Kadir Ahmad Parveez
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:86
  40. Genetic variants of the GDF9 gene were considered to be the potent gene markers for improving fecundity traits in Egyptian sheep and goats. Also, these favorable gene variants could be applied in the breeding ...

    Authors: Dalia M. Aboelhassan, Ahmed M. Darwish, Neama I. Ali, Inas S. Ghaly and Ibrahim M. Farag
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:85
  41. Breast cancer (BC) is the common primary tumor among females. Hence, there is an urgent need to improve the early prediction and diagnosis of BC. For that reason, the object of the current study is to analyze ...

    Authors: Noha M. Bakr, Magda Sayed Mahmoud, Reem Nabil, Hussein Boushnak and Menha Swellam
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:84
  42. Iron chelate sources and their concentrations are important factors in in vitro propagation of date palm. This study’s objective was to investigate the effect of the iron chelated form on the growth and develo...

    Authors: Ahmed Madi Waheed Al-Mayahi
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:83
  43. Several coronavirus vaccine have been fast-tracked to halt the pandemic, the usage of immune adjuvants that can boost immunological memory has come up to the surface. This is particularly of importance in view...

    Authors: Antoine Fakhry AbdelMassih, Rahma Menshawey, Jumana H. Ismail, Reem J. Husseiny, Yousef M. Husseiny, Shenoda Yacoub, Aya Kamel, Rafeef Hozaien, Elaria Yacoub, Esraa Menshawey, Abanoub Abdelmalek, Ahmed Abouelazaem, Ahmed Elhatw, Ahmed Aboelmaaty, Alaaelrahman Shahib, Amany Mansour…
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:82
  44. Pasteurella multocida is the main cause of several infections of farm animals, and the immunity gained from commercial vaccines is for the short term only and needs to be routinely administered, so work on new va...

    Authors: Ahmed A. M. Yassein, Ayaat A. Teleb, Gamal M. Hassan and Zaki A. El Fiky
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:81
  45. The use of natural preservatives became of great interest; good examples of these natural preservation agents are plant peels. The use of plant peels has dual benefits; first is their antimicrobial activity ag...

    Authors: Safynaz Magdy Hanafy, Yasser Mohamed Abd El-Shafea, Waleed Diaeddeen Saleh and Hayam Mohamed Fathy
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:80
  46. Elevated ultraviolet-B (UV-B) radiation is potentially deleterious to many organisms specifically crop plants and has become a global challenge. Rice is an exceptionally important staple food which is grown wo...

    Authors: Raheel Shahzad, Mohamed Ewas, Putri Widyanti Harlina, Shahid Ullah Khan, Pan Zhenyuan, Xinhui Nie and Elsayed Nishawy
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:79
  47. Acute pancreatitis, the most frequent hospitalization reason in internal medicine ward among gastrointestinal diseases, is burdened by high mortality rate. The disease manifests mainly in a mild form, but abou...

    Authors: Ombretta Para, Lorenzo Caruso, Maria Teresa Savo, Elisa Antonielli, Eleonora Blasi, Fabio Capello, Tiziana Ciarambino, Lorenzo Corbo, Armando Curto, Margherita Giampieri, Lucia Maddaluni, Giacomo Zaccagnini and Carlo Nozzoli
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:77
  48. Environmental contamination by microbes is a major public health concern. A damp environment is one of the potential sources for microbe proliferation. Smart synthesis nanocatalytic coatings on surfaces, food,...

    Authors: Moatasem Al-Salih, Syakirah Samsudin and Siti Suri Arshad
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:76

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