Journal of Genetic Engineering and Biotechnology is affiliated with the Academy of Scientific Research and Technology and National Research Centre
Articles
Page 5 of 13
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Citation: Journal of Genetic Engineering and Biotechnology 2022 20:137
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Immunoinformatics approach to epitope-based vaccine design against the SARS-CoV-2 in Bangladeshi patients
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic which has brought a great challenge to public health. After the f...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:136 -
Eco-physiological response and genotoxicity induced by crude petroleum oil in the potential phytoremediator Vinca rosea L
Phytoremediation is determined as an emerging green technology suitable for the safe remediation and restoration of polluted terrestrial and aquatic environments. In this study, the assessment of an ornamental...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:135 -
2,4-Dichlorophenol biotransformation using immobilized marine halophilic Bacillus subtilis culture and laccase enzyme: application in wastewater treatment
2,4-Dichlorophenol (2,4-DCP) is a very toxic aromatic compound for humans and the environment and is highly resistant to degradation. Therefore, it is necessary to develop efficient remediation and cost-effect...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:134 -
Bacteriophage as a potential therapy to control antibiotic-resistant Pseudomonas aeruginosa infection through topical application onto a full-thickness wound in a rat model
Antibiotic-resistant Pseudomonas aeruginosa (P. aeruginosa) is one of the most critical pathogens in wound infections, causing high mortality and morbidity in severe cases. However, bacteriophage therapy is a pot...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:133 -
In vitro evaluation of probiotic potential and enzymatic profiling of Pichia kudriavzevii Y33 isolated from traditional home-made mango pickle
Fermented foods are the results of metabolic activities of various microorganisms. People have traditionally known how to culture desirable microorganisms, primarily lactic acid bacteria, yeasts, and filamento...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:132 -
Phytogenic silver nanoparticles from tissue-cultured Kaempferia angustifolia — an underutilized medicinal herb: a comparative antibacterial study on urinary pathogens
Ethnomedicinally important Kaempferia angustifolia is a rhizomatous aromatic herb belonging to the family Zingiberaceae. The present manuscript deals with the green synthesis of silver nanoparticles through a rap...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:131 -
In vitro propagation for conservation and genetic fidelity of the near threatened Dimocarpus longan plant
Dimocarpus longan is a tropical tree that produces edible fruit. It is a neglected plant species that is listed as near threatened. In spite of its economic value, the propagation of longan cultivar using convent...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:130 -
An in silico pipeline approach uncovers a potentially intricate network involving spike SARS-CoV-2 RNA, RNA vaccines, host RNA-binding proteins (RBPs), and host miRNAs at the cellular level
In the last 2 years, we have been fighting against SARS-CoV-2 viral infection, which continues to claim victims all over the world. The entire scientific community has been mobilized in an attempt to stop and ...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:129 -
In silico designing of a recombinant multi-epitope antigen for leprosy diagnosis
Leprosy is caused by Mycobacterium leprae and Mycobacterium lepromatosis. Most of the affected population lives in low-income countries and may take up to 10 years to show any clinical signs, which is how physic...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:128 -
Meta-analysis highlights the key drought responsive genes in genes: PEPC and TaSAG7 are hubs response networks
Wheat is the most important cereal. One of the environmental stresses is drought that harm the production of many cereals and every year due to low rainfall and frequent droughts, the need to produce plants re...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:127 -
Impact of rs11024102 PLEKHA7, rs3753841 COL11A1 single nucleotide polymorphisms, and serum levels of oxidative stress markers on the risk of primary angle-closure glaucoma in Egyptians
Primary angle-closure glaucoma (PACG) is one of the major causes of blindness in the Middle East with genetic loci and systemic oxidative stress as potential risk factors. The current case-control study aimed ...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:126 -
Plant catalase in silico characterization and phylogenetic analysis with structural modeling
Catalase (EC 1.11.1.6) is a heme-containing tetrameric enzyme that plays a critical role in signaling and hydrogen peroxide metabolism. It was the first enzyme to be crystallized and isolated. Catalase is a we...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:125 -
Genome-wide identification, phylogeny, and expression profiling analysis of shattering genes in rapeseed and mustard plants
Non-synchronized pods shattering in the Brassicaceae family bring upon huge yield losses around the world. The shattering process was validated to be controlled by eight genes in Arabidopsis, including SHP1, SHP2
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:124 -
Osteogenic enhancement of modular ceramic nanocomposites impregnated with human dental pulp stem cells: an approach for bone repair and regenerative medicine
Human dental pulp-derived mesenchymal stem cells (hDP-MSCs) are a promising source of progenitor cells for bone tissue engineering. Nanocomposites made of calcium phosphate especially hydroxyapatite (HA) offer...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:123 -
Association study of HIF-1α rs11549465 and VEGF rs3025039 genetic variants with diabetic retinopathy in Egyptian patients: crosslinks with angiogenic, inflammatory, and anti-inflammatory markers
Genetic factors are implicated in the progression of DR—a global cause of blindness. Hence, the current work investigated the association of HIF-1α rs11549465 and VEGF rs3025039 genetic variants with the differen...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:122 -
Safe production of Aspergillus terreus xylanase from Ricinus communis: gene identification, molecular docking, characterization, production of xylooligosaccharides, and its biological activities
The production of industrial enzymes such as xylanase using sufficient cost-effective substrates from potent microorganisms is considered economically feasible. Studies have reported castor cake (Ricinus communis
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:121 -
In silico mutational analysis to identify the role and pathogenicity of BCL-w missense variants
Intrinsic pathway of apoptosis is generally mediated by BCL-2 (B cell lymphoma 2) family of proteins; they either induce or inhibit the apoptosis. Overexpression of BCL-2 in cancer cell may lead to delay in ap...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:120 -
TTN as a candidate gene for distal arthrogryposis type 10 pathogenesis
Arthrogryposis is a medical term used to describe congenital contractures which often affect multiple limbs. Distal arthrogryposis (DA) is one of the major categories of arthrogryposis that primarily affects t...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:119 -
Application of reverse vaccinology to design a multi-epitope subunit vaccine against a new strain of Aeromonas veronii
Aeromonas veronii is one of the most common pathogens of freshwater fishes that cause sepsis and ulcers. There are increasing numbers of cases showing that it is a significant zoonotic and aquatic agent. Epidemi...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:118 -
Correlating SFTPC gene variants to interstitial lung disease in Egyptian children
Interstitial lung disease (ILD) is a broad heterogeneous group of lung disorders that is characterized by inflammation of the lungs. Surfactant dysfunction disorders are a rare form of ILD diseases that result...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:117 -
Exploring the genetic makeup and population structure among Capsicum accessions for crop improvement and breeding curriculum insights
Capsicum or chilli is an important crop in India which exhibits immense structural and genetic variations reflecting their intra- and inter-specific relationships. The aim of this study was to establish relations...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:116 -
Polyhydroxyalkanoate recovery from newly screened Bacillus sp. LPPI-18 using various methods of extraction from Loktak Lake sediment sample
Nowadays, the conventional plastic wastes are very challenging to environments and its production cost also creates an economic crisis due to petrochemical-based plastic. In order to solve this problem, the cu...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:115 -
Genetic analysis of X-chromosomal short tandem repeat (X-STR) frequencies in Arab Iraqi male population
The X-chromosome short tandem repeat (STR) polymorphisms are a particular tool in the fields of human population genetics and personal identification. It was necessary in investigating complex kinship or defic...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:114 -
Characterization of halo-tolerant plant growth promoting endophytic Bacillus licheniformis MHN 12
Endophytic bacteria overlay significant role in plant growth promotion, eliminating phyto-pathogens and combating stress-conditions. In the present study, we aimed to screen high salt tolerant bacteria and stu...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:113 -
MLPA as a genetic assay for the prenatal diagnosis of common aneuploidy: the first Egyptian experience
The prenatal diagnosis of syndromes caused by chromosomal abnormality is a long-established part of obstetric care. Several DNA-based molecular approaches have provided rapid prenatal diagnosis of of cytogenom...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:112 -
TRIM21 chimeric protein as a new molecular tool for multispecies IgG detection
The production of monoclonal antibodies for immunoglobulin detection is not cost-effective, while polyclonal antibody production depends on laboratory animals, raising concerns on animal welfare. The widesprea...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:111 -
Genetic structure of some candidate genes of repeat breeder syndrome in Egyptian buffaloes
This study aimed to explore the association between polymorphisms in three genes: leptin (LEP), leptin receptor (LEPR), and BMP4, and incidence of repeat breeding in Egyptian buffaloes.
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:110 -
Genetic and phenotypic diversity of microsymbionts nodulating promiscuous soybeans from different agro-climatic conditions
Global food supply is highly dependent on field crop production that is currently severely threatened by changing climate, poor soil quality, abiotic, and biotic stresses. For instance, one of the major challe...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:109 -
Molecular docking and identification of G-protein-coupled receptor 120 (GPR120) agonists as SARS COVID-19 MPro inhibitors
COVID-19 has become a pandemic, and any new drug for treating the disease could save millions of lives. Several drugs already in use for other diseases and medical conditions are repurposed for treating COVID-...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:108 -
Development of an efficient micropropagation system for Dioscorea bulbifera L. and phytochemical profile of regenerated plants
The present study was designed to develop an improved in vitro regeneration system for Dioscorea bulbifera using mature nodal explants. Direct organogenesis from nodal segments was achieved by culturing the nodal...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:107 -
Bioinformatics approaches and applications in plant biotechnology
In recent years, major advance in molecular biology and genomic technologies have led to an exponential growth in biological information. As the deluge of genomic information, there is a parallel growth in the...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:106 -
A new insight on genetic diversity of sweet oranges: CAPs-SSR and SSR markers
Citrus species are among the most important and widely consumed fruit trees in the world and are subjected to increasing global cultivation. Sweet orange (Citrus sinensis L. Osbeck) is one of 30 species of citrus...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:105 -
The consequences of viral infection on host DNA damage response: a focus on SARS-CoVs
DNA damage and genome instability in host cells are introduced by many viruses during their life cycles. Severe acute respiratory syndrome coronaviruses (SARS-CoVs) manipulation of DNA damage response (DDR) is...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:104 -
Comparative phylogeny and evolutionary analysis of Dicer-like protein family in two plant monophyletic lineages
Small RNAs (sRNAs) that do not get untranslated into proteins exhibit a pivotal role in the expression regulation of their cognate gene(s) in almost all eukaryotic lineages, including plants. Hitherto, numerou...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:103 -
In silico structural and functional characterization of Antheraea mylitta cocoonase
Cocoonase is a serine protease present in sericigenous insects and majorly involved in dissolving of sericin protein allowing moth to escape. Cocoon structure is made up of sericin protein which holds fibroin ...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:102 -
Senescence-associated proteins and nitrogen remobilization in grain filling under drought stress condition
Plants use escape strategies including premature senescence and leaf reduction to cope in response to drought stress, which in turn reduces plant leaves and photosynthesis. This strategy allows the new generat...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:101 -
In silico designing of a multi-epitope vaccine against Burkholderia pseudomallei: reverse vaccinology and immunoinformatics
Burkholderia pseudomallei is an infectious agent causing severe disease melioidosis resulting in pneumonia, fever, and acute septicemia in humans. B. pseudomallei show resistance to drugs. No such FDA-approved va...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:100 -
Biochemical characterization and peptide mass fingerprinting of two glutathione transferases from Biomphalaria alexandrina snails (Gastropoda: Planorbidae)
The freshwater snails Biomphalaria alexandrina (Gastropoda: Planorbidae) has public health importance of being an intermediate host of Schistosoma mansoni, the parasite species that causes intestinal schistosomia...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:99 -
Application of Baculovirus Expression Vector system (BEV) for COVID-19 diagnostics and therapeutics: a review
The baculovirus expression vector system has been developed for expressing a wide range of proteins, including enzymes, glycoproteins, recombinant viruses, and vaccines. The availability of the SARS-CoV-2 geno...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:98 -
Correlation of preferentially expressed antigen of melanoma (PRAME) gene expression with clinical characteristics in acute leukemia patients
Preferentially expressed antigen of melanoma (PRAME) gene is regularly overexpressed in acute leukemia (AL) and other malignant diseases which are recognized by human leucocyte antigen (HLA-24) located in the ...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:97 -
Exploring the genetic and phenotypic diversity within and between onion (Allium cepa L.) ecotypes in Morocco
Gaining insight into crop diversity, both at the genetic and phenotypic levels, is of prime importance for onion breeding with an enhanced yield and quality in combination with improved resistance to biotic an...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:96 -
A sequential toggle cell-SELEX DNA aptamer for targeting Staphylococcus aureus, Streptococcus agalactiae, and Escherichia coli bacteria
Mastitis is an inflammation of the mammary glands caused by a microbial infection. The common bacteria causing this infection in dairy farms are Staphylococcus aureus, Streptococcus agalactiae, and Escherichia co...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:95 -
Molecular docking and nucleotide sequencing of successive expressed recombinant fungal peroxidase gene in E.coli
Fungal peroxidases are oxidoreductases that utilize hydrogen peroxide to catalyze lignin biodegradation.
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:94 -
Regulation of Sirtuin-3 and ERK1/2/p38MAPK by the combination Ga nanoparticles/γ-radiation low dosage: an effective approach for treatment of hepatocellular carcinoma
Synthesized gallium nanoparticles synthesized by grape seed extract were characterized with spherical shape and size range less than100 nm, possessing the functional groups of the biological material. The purp...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:93 -
Determination of deleterious single-nucleotide polymorphisms of human LYZ C gene: an in silico study
Single-nucleotide polymorphisms (SNPs) have a crucial function in affecting the susceptibility of individuals to diseases and also determine how an individual responds to different treatment options. The prese...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:92 -
Toxicity monitoring of solvents, hydrocarbons, and heavy metals using statistically optimized model of luminous Vibrio sp. 6HFE
The utilization of bioluminescent bacteria in environmental monitoring of water contaminates considers being a vital and powerful approach. This study aimed to isolate, optimize, and apply luminescent bacteria...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:91 -
Stable, efficient, and cost-effective system for the biosynthesis of recombinant bacterial cellulose in Escherichia coli DH5α platform
Owing to its remarkable mechanical properties that surpass the plant-based cellulose, bacterial cellulose production has been targeted for commercialization during the last few years. However, the large-scale ...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:90 -
In silico multi-epitope Bunyumwera virus vaccine to target virus nucleocapsid N protein
Bunyumwera virus can cause 82% mortality in humans currently with no vaccine or drugs for treatment. We described an in silico multi-epitope vaccine targeting Bunyumwera virus nucleocapsid N-protein and predic...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:89 -
QSAR, homology modeling, and docking simulation on SARS-CoV-2 and pseudomonas aeruginosa inhibitors, ADMET, and molecular dynamic simulations to find a possible oral lead candidate
In seek of potent and non-toxic iminoguanidine derivatives formerly assessed as active Pseudomonas aeruginosa inhibitors, a combined mathematical approach of quantitative structure-activity relationship (QSAR)...
Citation: Journal of Genetic Engineering and Biotechnology 2022 20:88
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