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  1. Accessing COVID-19 vaccines is a challenge despite successful clinical trials. This burdens the COVID-19 treatment gap, thereby requiring accelerated discovery of anti-SARS-CoV-2 agents. This study explored th...

    Authors: Von Novi O. de Leon, Joe Anthony H. Manzano, Delfin Yñigo H. Pilapil IV, Rey Arturo T. Fernandez, James Kyle Anthony R. Ching, Mark Tristan J. Quimque, Jay Carl M. Agbay, Kin Israel R. Notarte and Allan Patrick G. Macabeo
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:104
  2. Plasmodium falciparum is the most deadly and leading cause of morbidity and mortality in Africa. About 90% of all malaria deaths in the world today occur in Sub-Saharan Africa especially in children aged < 5 year...

    Authors: Claire Aguttu, Brenda Apio Okech, Ambrose Mukisa and George William Lubega
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:103
  3. Actinomycetes associated with marine sponge represent a promising source of bioactive compounds. Herein, we report the isolation, identification, and bioactivity evaluation of Streptomyces sp. NMF6 associated wit...

    Authors: Nayer Mohamed Fahmy and Asmaa Mohamed Abdel-Tawab
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:102
  4. The SARS-CoV-2 belongs to Coronaviridae family infects host cells by the interaction of its spike glycoprotein and angiotensin-converting enzyme 2 (ACE 2) of host cells. Upon entry, the virus uses its RNA depe...

    Authors: Lokanathan Srikanth and Potukuchi Venkata Gurunadha Krishna Sarma
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:101
  5. Hypoxia refers to the condition of low oxygen pressure in the atmosphere and characterization of response to hypoxia as a biological complex puzzle, is challenging. Previously, we carried out a comparative gen...

    Authors: Hamed Kharrati-Koopaee, Esmaeil Ebrahimie, Mohammad Dadpasand, Ali Niazi, Rugang Tian and Ali Esmailizadeh
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:100
  6. Soil salinity has been one of the biggest hurdles in achieving better crop yield and quality. Plant growth-promoting rhizobacteria (PGPR) are the symbiotic heterogeneous bacteria that play an important role in...

    Authors: Arti Sharma, Kamal Dev, Anuradha Sourirajan and Madhu Choudhary
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:99
  7. Chronic lymphocytic leukemia (CLL) is the most common form of adult leukemia. This disease is genetically heterogeneous, and approximately 85% of patients with CLL harbor chromosomal aberrations that are consi...

    Authors: Ola M. Eid, Rania M. A. Abdel Kader, Lamiaa A. Fathalla, Amany H. Abdelrahman, Ahmed Rabea, Rana Mahrous and Maha M. Eid
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:98
  8. Plant-associated microbes (endophytes) have a significant relationship to enhance plant growth and crop productivity by producing proficient bioactive metabolites. Since endophytes promoted plant growth either...

    Authors: Mustafa Elsayed Abd Elsallam, Shahira Hussainy EL-Moslamy, Ahmed Abd El-Al and Hoda Farouk Zahran
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:97
  9. In crop plants, to cope up with the demand of food for rising population, revolutionary crop improvement programmes are being implemented for higher and higher yields. Abiotic stress, especially at flowering s...

    Authors: Sridevi Muppala, Pavan Kumar Gudlavalleti, Kodandarami Reddy Malireddy, Sateesh Kumar Puligundla and Premalatha Dasari
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:96
  10. Drug response is below genetic influence, proven by the genetic variants. Pharmacogenetics trials are performed in many diseases, including coronary artery disease. This study was designed to determine the gen...

    Authors: Shaimaa Y. Abdulfattah and Salwa J. Al-Awadi
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:95
  11. Pest control strategies almost entirely rely on chemical insecticides, which cause environmental problems such as biosphere deterioration and emergence of resistant pests. Bio-pesticide is an alternative appro...

    Authors: Getachew Bantihun and Mulugeta Kebede
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:94
  12. Jewel orchid is the common name of several orchid species which can be alike in morphological characteristics, but variable in medicinal properties. At present, two DNA barcode loci, namely, maturase K (matK) and...

    Authors: Viet The Ho, Thi Kim Phuong Tran, Thi Thanh Tram Vu and Sasanti Widiarsih
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:93
  13. Candida albicans is an opportunistic human fungal pathogen responsible for superficial and systemic life-threatening infections. Treating these infections is challenging as many clinical isolates show increased d...

    Authors: Wasim Uddin, Darshan Dhabalia, S. M. Udaya Prakash and M. Anaul Kabir
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:92
  14. Bladder cancer is considered heterogeneous diseases with two major subgroups: non-muscle- invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC). It is a major healthcare problem, and it is ...

    Authors: Mohamed K. Khalifa, Noha M. Bakr, Amal Ramadan, Khaled M. Abd Elwahab, Esam Desoky, Amira M. Nageeb and Menha Swellam
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:91
  15. Whilst traditional strategies to increase transfection efficiency of non-viral systems aimed at modifying the vector or the polyplexes/lipoplexes, biomaterial-mediated gene delivery has recently sparked increa...

    Authors: Valeria Graceffa
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:90
  16. Cockayne syndrome (CS), which was discovered by Alfred Cockayne nearly 75 years ago, is a rare autosomal recessive disorder characterized by growth failure, neurological dysfunction, premature aging, and other...

    Authors: Amr Ghit
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:88
  17. Microbial community is one of the diversified communities of the marine environment. Studies have shown that microorganisms isolated from the marine environment are metabolically active and have adapted to lif...

    Authors: Teja Mandragutti, Muni Kumar Dokka, Bindiya Panchagnula and Sudhakar Godi
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:87
  18. Genome editing employing the CRISPR/Cas9 system has been widely used and has become a promising tool for plant gene functional studies and crop improvement. However, most of the applied CRISPR/Cas9 systems tar...

    Authors: Bohari Bahariah, Mat Yunus Abdul Masani, Omar Abd Rasid and Ghulam Kadir Ahmad Parveez
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:86
  19. Genetic variants of the GDF9 gene were considered to be the potent gene markers for improving fecundity traits in Egyptian sheep and goats. Also, these favorable gene variants could be applied in the breeding ...

    Authors: Dalia M. Aboelhassan, Ahmed M. Darwish, Neama I. Ali, Inas S. Ghaly and Ibrahim M. Farag
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:85
  20. Breast cancer (BC) is the common primary tumor among females. Hence, there is an urgent need to improve the early prediction and diagnosis of BC. For that reason, the object of the current study is to analyze ...

    Authors: Noha M. Bakr, Magda Sayed Mahmoud, Reem Nabil, Hussein Boushnak and Menha Swellam
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:84
  21. Iron chelate sources and their concentrations are important factors in in vitro propagation of date palm. This study’s objective was to investigate the effect of the iron chelated form on the growth and develo...

    Authors: Ahmed Madi Waheed Al-Mayahi
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:83
  22. Several coronavirus vaccine have been fast-tracked to halt the pandemic, the usage of immune adjuvants that can boost immunological memory has come up to the surface. This is particularly of importance in view...

    Authors: Antoine Fakhry AbdelMassih, Rahma Menshawey, Jumana H. Ismail, Reem J. Husseiny, Yousef M. Husseiny, Shenoda Yacoub, Aya Kamel, Rafeef Hozaien, Elaria Yacoub, Esraa Menshawey, Abanoub Abdelmalek, Ahmed Abouelazaem, Ahmed Elhatw, Ahmed Aboelmaaty, Alaaelrahman Shahib, Amany Mansour…
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:82
  23. Pasteurella multocida is the main cause of several infections of farm animals, and the immunity gained from commercial vaccines is for the short term only and needs to be routinely administered, so work on new va...

    Authors: Ahmed A. M. Yassein, Ayaat A. Teleb, Gamal M. Hassan and Zaki A. El Fiky
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:81
  24. The use of natural preservatives became of great interest; good examples of these natural preservation agents are plant peels. The use of plant peels has dual benefits; first is their antimicrobial activity ag...

    Authors: Safynaz Magdy Hanafy, Yasser Mohamed Abd El-Shafea, Waleed Diaeddeen Saleh and Hayam Mohamed Fathy
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:80
  25. Elevated ultraviolet-B (UV-B) radiation is potentially deleterious to many organisms specifically crop plants and has become a global challenge. Rice is an exceptionally important staple food which is grown wo...

    Authors: Raheel Shahzad, Mohamed Ewas, Putri Widyanti Harlina, Shahid Ullah Khan, Pan Zhenyuan, Xinhui Nie and Elsayed Nishawy
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:79
  26. Acute pancreatitis, the most frequent hospitalization reason in internal medicine ward among gastrointestinal diseases, is burdened by high mortality rate. The disease manifests mainly in a mild form, but abou...

    Authors: Ombretta Para, Lorenzo Caruso, Maria Teresa Savo, Elisa Antonielli, Eleonora Blasi, Fabio Capello, Tiziana Ciarambino, Lorenzo Corbo, Armando Curto, Margherita Giampieri, Lucia Maddaluni, Giacomo Zaccagnini and Carlo Nozzoli
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:77
  27. Environmental contamination by microbes is a major public health concern. A damp environment is one of the potential sources for microbe proliferation. Smart synthesis nanocatalytic coatings on surfaces, food,...

    Authors: Moatasem Al-Salih, Syakirah Samsudin and Siti Suri Arshad
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:76
  28. Hemophilia B (HB) (also known as Christmas disease) is a rare X-linked recessive disorder characterized by spontaneous or prolonged hemorrhages caused by mutations in Factor 9 (F9) gene leading to deficient or de...

    Authors: Ghada Y. El-Kamah, Rehab M. Mosaad, Mohamed B. Taher and Khalda S. Amr
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:75
  29. The green synthesis strategy of metallic nanoparticles (NPs) has become popular due to being environmentally friendly. Stable silver nanoparticles (AgNPs) have been synthesized by natural products such as star...

    Authors: Md. Abdullah Al Masud, Hamid Shaikh, Md. Shamsul Alam, M. Minnatul Karim, M. Abdul Momin, M. Ariful Islam and G. M. Arifuzzaman Khan
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:74
  30. Lipases (EC 3.1.1.3) catalyze the hydrolysis of oil into free fatty acids and glycerol forming the 3rd largest group of commercialized enzymes. Plant lipases grab attention recently because of their specificit...

    Authors: Shradha Rani, Priya Kumari, Raju Poddar and Soham Chattopadhyay
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:73
  31. The ability to produce microbial bioactive compounds makes actinobacteria one of the most explored microbes among prokaryotes. The secondary metabolites of actinobacteria are known for their role in various ph...

    Authors: Manal Selim Mohamed Selim, Sayeda Abdelrazek Abdelhamid and Sahar Saleh Mohamed
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:72
  32. The concern regarding a post-antibiotic era with increasing drug resistance by pathogens imposes the need to discover alternatives for existing antibiotics. Antimicrobial peptides (AMPs) with their versatile t...

    Authors: S. Neelima, K. Archana, P. P. Athira, M. V. Anju, V. V. Anooja, I. S. Bright Singh and Rosamma Philip
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:71
  33. Acute hepatopancreatic necrosis disease (AHPND) is caused by toxin-producing strains of Vibrio parahaemolyticus which contain deadly binary toxins PirAvp and PirBvp encoded in pVA1 plasmid. The polyclonal antibod...

    Authors: Ngoc-Diem Duong, Khai-Hoan Nguyen-Phuoc, Kim-Yen Thi Do, Nguyet-Thu Thi Nguyen, Thuoc Linh Tran and Hieu Tran-Van
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:70
  34. TSST-1 is a secretory and pyrogenic superantigen that is being responsible for staphylococcal mediated food poisoning and associated clinical manifestations. It is one of the main targets for the construction ...

    Authors: Harish Babu Kolla, Chakradhar Tirumalasetty, Krupanidhi Sreerama and Vijaya Sai Ayyagari
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:69
  35. Trachyspermum ammi is one of the key medicinal plant species with many beneficial properties. Thymol is the most important substance in the essential oil of this plant. Thymol is a natural monoterpene phenol with...

    Authors: Masoumeh Nomani and Masoud Tohidfar
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:68
  36. The heterologous expression of isopentenyl transferase (IPT) under the transcriptional control of the senescence-associated receptor-like kinase (SARK) promoter delayed cellular senescence and, through it, inc...

    Authors: Ailin Beznec, Paula Faccio, Daniel J. Miralles, Leonor G. Abeledo, Cecilia Decima Oneto, María de Belén Garibotto, Germán Gonzalez, Federico Moreyra, Matías Elizondo, Mónica Ruíz, Dalia Lewi, Eduardo Blumwald, Berta Llorente, Antonio Díaz Paleo and Ezequiel Bossio
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:67
  37. Aberrant DNA methylation of phosphatase and tensin homolog (PTEN) gene has been found in many cancers. The object of this study was to evaluate the clinical impact of PTEN methylation as a prognostic marker in...

    Authors: Amal Ramadan, Maha Hashim, Amr Abouzid and Menha Swellam
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:66
  38. The antineoplastic herb, Catharanthus roseus is a classified high-value low-volume medicinal herb which is in global attention of scientific research for modulation of its monoterpenoid indole alkaloids (MIA) pat...

    Authors: Vyoma Mistry, Abhishek Sharma and Ajay Kumar Mathur
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:65
  39. Date palm tree (Phoenix dactylifera L.) is a perennial monocotyledonous plant belonging to the Arecaceae family, a special plant with extraordinary nature that gives eminent contributions in agricultural sustaina...

    Authors: Workia Ahmed, Tileye Feyissa, Kassahun Tesfaye and Sumaira Farrakh
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:64
  40. The management of stray dog population has been of utmost importance due to their overpopulation, increase in dog bites incidence, and rabies. Contraceptive vaccines, a non-surgical alternative to spaying and ...

    Authors: Nathaniel Philip Sandam, Dhamodhar Prakash and Prashanth Thimmareddy
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:63
  41. Lupeol, a triterpene bioactive compound isolated from Indian traditional plant Crateva adansonii acted as promising and alternative anti-inflammatory agent to treatments of diseases related to inflammation. The i...

    Authors: Thirumalaisamy Rathinavel, Subramanian Ammashi and Gnanendra Shanmugam
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:62
  42. Alzheimer’s disease is a leading neurodegenerative disease worldwide and is the 6th leading cause of death in the USA. AD is a very complex disease and the drugs available in the market cannot fully cure it. T...

    Authors: Rohit Shukla and Tiratha Raj Singh
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:61
  43. Rosa canina is one of the most popular rose species which is widely used as the rootstock for the propagation of rose cultivars. The purpose of the present study is to improve the in vitro propagation efficiency ...

    Authors: Leila Samiei, Mahboubeh Davoudi Pahnehkolayi, Ali Tehranifar and Zahra Karimian
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:60
  44. Alfalfa (Medicago sativa L.) is a perennial plant, which is high in nutritional value and resistant to environmental conditions, and it is one of most frequently preferred feed crop among the leguminous family. I...

    Authors: Büşra Yazıcılar, Gholamreza Jannati and Ismail Bezirganoglu
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:59
  45. Cellulose is the primary component of the plant cell wall and an important source of energy for the ruminant and microbial protein synthesis in the rumen. Cell wall content is digested by anaerobic fermentatio...

    Authors: Anila Hoda, Myqerem Tafaj and Enkelejda Sallaku
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:58
  46. Bio-nanotechnology is considered as one of the low-cost approaches that have been utilized in production of nanomaterials. The current research aimed at investigating the influence of different types of Actino...

    Authors: Mostafa Mabrouk, Tarek A. Elkhooly and Shaimaa K. Amer
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:57
  47. Evaluation of genetic diversity and relationships among crop wild relatives is an important task in crop improvement. The main objective of the current study was to estimate molecular variability within the se...

    Authors: Ghazal Ghobadi, Alireza Etminan, Ali Mehras Mehrabi and Lia Shooshtari
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:56
  48. Lipases are promising biocatalysts for industrial applications and attract attention to be explored. A novel acidic lipase has been isolated from the lipolytic bacteria Micrococcus luteus EMP48-D (LipEMP48-D) scr...

    Authors: Selfela Restu Adina, Antonius Suwanto, Anja Meryandini and Esti Puspitasari
    Citation: Journal of Genetic Engineering and Biotechnology 2021 19:55

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