Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Delling FN, Djousse L, Elkind MSV, Ferguson JF, Fornage M, Khan SS, Kissela BM, Knutson KL, Kwan TW, Lackland DT, Lewis TT, Lichtman JH, Longenecker CT, Loop MS, Lutsey PL, Martin SS, Matsushita K, Moran AE, Mussolino ME, Perak AM, Rosamond WD, Roth GA, Sampson UKA, Satou GM, Schroeder EB, Shah SH, Shay CM, Spartano NL, Stokes A, Tirschwell DL, VanWagner LB, Tsao CW (2020) Heart disease and stroke statistics-2020 update: a report from the American Heart Association. Circulation 141:e139–e596
Article
Google Scholar
Saleh M and Ambrose J A (2018) Understanding myocardial infarction. F1000Res 7:
Griendling KK, FitzGerald GA (2003) Oxidative stress and cardiovascular injury: part I: basic mechanisms and in vivo monitoring of ROS. Circulation 108:1912–1916
Article
Google Scholar
Shiomi T, Tsutsui H, Matsusaka H, Murakami K, Hayashidani S, Ikeuchi M, Wen J, Kubota T, Utsumi H, Takeshita A (2004) Overexpression of glutathione peroxidase prevents left ventricular remodeling and failure after myocardial infarction in mice. Circulation 109:544–549
Article
Google Scholar
Lubos E, Loscalzo J, Handy DE (2011) Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 15:1957–1997
Article
Google Scholar
Jefferies S, Kote-Jarai Z, Goldgar D, Houlston R, Frazer-Williams MJ, A'Hern R, Eeles R, Henk J, Gore M, Rhys-Evans P, Archer D, Bishop K, Solomon E, Hodgson S, McGurk M, Hibbert J, O'Connell M, Partridge M, Chevretton E, Calman F, Saunders M, Shotton K, Brown A, Whittaker S, Foulkes W (2005) Association between polymorphisms of the GPX1 gene and second primary tumours after index squamous cell cancer of the head and neck. Oral Oncol 41:455–461
Article
Google Scholar
Toussaint O, Houbion A, Remacle J (1993) Relationship between the critical level of oxidative stresses and the glutathione peroxidase activity. Toxicology 81:89–101
Article
Google Scholar
Suzen HS, Gucyener E, Sakalli O, Uckun Z, Kose G, Ustel D, Duydu Y (2010) CAT C-262T and GPX1 Pro198Leu polymorphisms in a Turkish population. Mol Biol Rep 37:87–92
Article
Google Scholar
Blankenberg S, Rupprecht HJ, Bickel C, Torzewski M, Hafner G, Tiret L, Smieja M, Cambien F, Meyer J, Lackner KJ (2003) Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease. N Engl J Med 349:1605–1613
Article
Google Scholar
Upchurch GR Jr, Welch GN, Fabian AJ, Freedman JE, Johnson JL, Keaney JF Jr, Loscalzo J (1997) Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J Biol Chem 272:17012–17017
Article
Google Scholar
Hamanishi T, Furuta H, Kato H, Doi A, Tamai M, Shimomura H, Sakagashira S, Nishi M, Sasaki H, Sanke T, Nanjo K (2004) Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in Japanese type 2 diabetic patients. Diabetes 53:2455–2460
Article
Google Scholar
Ravn-Haren G, Olsen A, Tjønneland A, Dragsted LO, Nexø BA, Wallin H, Overvad K, Raaschou-Nielsen O, Vogel U (2006) Associations between GPX1 Pro198Leu polymorphism, erythrocyte GPX activity, alcohol consumption and breast cancer risk in a prospective cohort study. Carcinogenesis 27:820–825
Article
Google Scholar
Forgione MA, Weiss N, Heydrick S, Cap A, Klings ES, Bierl C, Eberhardt RT, Farber HW, Loscalzo J (2002) Cellular glutathione peroxidase deficiency and endothelial dysfunction. Am J Physiol Heart Circ Physiol 282:H1255–H1261
Article
Google Scholar
Chen H, Yu M, Li M, Zhao R, Zhu Q, Zhou W, Lu M, Lu Y, Zheng T, Jiang J, Zhao W, Xiang K, Jia W, Liu L (2012) Polymorphic variations in manganese superoxide dismutase (MnSOD), glutathione peroxidase-1 (GPX1), and catalase (CAT) contribute to elevated plasma triglyceride levels in Chinese patients with type 2 diabetes or diabetic cardiovascular disease. Mol Cell Biochem 363:85–91
Article
Google Scholar
Forsberg L, de Faire U, Marklund SL, Andersson PM, Stegmayr B, Morgenstern R (2000) Phenotype determination of a common Pro-Leu polymorphism in human glutathione peroxidase 1. Blood Cells Mol Dis 26:423–426
Article
Google Scholar
Ramprasath T, Murugan PS, Kalaiarasan E, Gomathi P, Rathinavel A, Selvam GS (2012) Genetic association of glutathione peroxidase-1 (GPx-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) variants and their association of CAD in patients with type-2 diabetes. Mol Cell Biochem 361:143–150
Article
Google Scholar
Sergeeva TV, Chistiakov DA, Kobalava ZD, Moiseev VS (2001) Polymorphism of catalase and glutathione peroxidase genes in macrovascular complications in patients with non-insulin-dependent diabetes mellitus and hypertension. Genetika 37:418–421
Google Scholar
Malinow MR, Bostom AG, Krauss RM (1999) Homocyst(e)ine, diet, and cardiovascular diseases: a statement for healthcare professionals from the Nutrition Committee, American Heart Association. Circulation 99:178–182
Article
Google Scholar
Perła-Kaján J, Twardowski T, Jakubowski H (2007) Mechanisms of homocysteine toxicity in humans. Amino Acids 32:561–572
Article
Google Scholar
Herrmann W (2006) Significance of hyperhomocysteinemia. Clin Lab 52:367–374
Google Scholar
Jakubowski H (2006) Pathophysiological consequences of homocysteine excess. J Nutr 136:1741S–1749S
Article
Google Scholar
Sengupta S, Wehbe C, Majors AK, Ketterer ME, DiBello PM, Jacobsen DW (2001) Relative roles of albumin and ceruloplasmin in the formation of homocystine, homocysteine-cysteine-mixed disulfide, and cystine in circulation. J Biol Chem 276:46896–46904
Article
Google Scholar
Doshi SN, McDowell IF, Moat SJ, Payne N, Durrant HJ, Lewis MJ, Goodfellow J (2002) Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering. Circulation 105:22–26
Article
Google Scholar
Bagi Z, Ungvari Z, Koller A (2002) Xanthine oxidase-derived reactive oxygen species convert flow-induced arteriolar dilation to constriction in hyperhomocysteinemia: possible role of peroxynitrite. Arterioscler Thromb Vasc Biol 22:28–33
Article
Google Scholar
Petras M, Tatarkova Z, Kovalska M, Mokra D, Dobrota D, Lehotsky J, Drgova A (2014) Hyperhomocysteinemia as a risk factor for the neuronal system disorders. J Physiol Pharmacol 65:15–23
Google Scholar
Handy DE, Zhang Y, Loscalzo J (2005) Homocysteine down-regulates cellular glutathione peroxidase (GPx1) by decreasing translation. J Biol Chem 280:15518–15525
Article
Google Scholar
Weiss N, Heydrick S, Zhang YY, Bierl C, Cap A, Loscalzo J (2002) Cellular redox state and endothelial dysfunction in mildly hyperhomocysteinemic cystathionine beta-synthase-deficient mice. Arterioscler Thromb Vasc Biol 22:34–41
Article
Google Scholar
Durmaz A, Dikmen N (2007) Homocysteine effects on cellular glutathione peroxidase (GPx-1) activity under in vitro conditions. J Enzyme Inhib Med Chem 22:733–738
Article
Google Scholar
Schnabel R, Lackner KJ, Rupprecht HJ, Espinola-Klein C, Torzewski M, Lubos E, Bickel C, Cambien F, Tiret L, Münzel T, Blankenberg S (2005) Glutathione peroxidase-1 and homocysteine for cardiovascular risk prediction: results from the AtheroGene study. J Am Coll Cardiol 45:1631–1637
Article
Google Scholar
Tuck MK, Chan DW, Chia D, Godwin AK, Grizzle WE, Krueger KE, Rom W, Sanda M, Sorbara L, Stass S, Wang W, Brenner DE (2009) Standard operating procedures for serum and plasma collection: early detection research network consensus statement standard operating procedure integration working group. J Proteome Res 8:113–117
Article
Google Scholar
Dai S, Long Y (2015) Genotyping analysis using an RFLP assay. Methods Mol Biol 1245:91–99
Article
Google Scholar
Nemoto M, Nishimura R, Sasaki T, Hiki Y, Miyashita Y, Nishioka M, Fujimoto K, Sakuma T, Ohashi T, Fukuda K, Eto Y, Tajima N (2007) Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography. Cardiovasc Diabetol 6:23
Article
Google Scholar
Cheng ML, Chen CM, Ho HY, Li JM, Chiu DT (2009) Effect of acute myocardial infarction on erythrocytic glutathione peroxidase 1 activity and plasma vitamin e levels. Am J Cardiol 103:471–475
Article
Google Scholar
Shuvalova YA, Kaminnyi AI, Meshkov AN, Kukharchuk VV (2010) Pro198Leu polymorphism of GPx-1 gene and activity of erythrocytic glutathione peroxidase and lipid peroxidation products. Bull Exp Biol Med 149:743–745
Article
Google Scholar
Lei C, Niu XL, Wei J, Zhu JH, Zhu Y (2010) Polymorphisms in the glutathione peroxidase-1 gene associated with increased risk of Keshan disease. Zhonghua Yu Fang Yi Xue Za Zhi 44:617–621
Google Scholar
Biasioli S, Schiavon R (2000) Homocysteine as a cardiovascular risk factor. Blood Purif 18:177–182
Article
Google Scholar
Ansari R, Mahta A, Mallack E, Luo JJ (2014) Hyperhomocysteinemia and neurologic disorders: a review. J Clin Neurol 10:281–288
Article
Google Scholar
Baszczuk A, Kopczyński Z (2014) Hyperhomocysteinemia in patients with cardiovascular disease. Postepy Hig Med Dosw (Online) 68:579–589
Article
Google Scholar
Maldonado C, Soni CV, Todnem ND, Pushpakumar S, Rosenberger D, Givvimani S, Villafane J, Tyagi SC (2010) Hyperhomocysteinemia and sudden cardiac death: potential arrhythmogenic mechanisms. Curr Vasc Pharmacol 8:64–74
Article
Google Scholar
Ganguly P, Alam SF (2015) Role of homocysteine in the development of cardiovascular disease. Nutr J 14:6
Article
Google Scholar
Lentz SR (2005) Mechanisms of homocysteine-induced atherothrombosis. J Thromb Haemost 3:1646–1654
Article
Google Scholar
Heinecke JW, Rosen H, Suzuki LA, Chait A (1987) The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells. J Biol Chem 262:10098–10103
Article
Google Scholar
Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, Graham I (1991) Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med 324:1149–1155
Article
Google Scholar
Naureen A, Munazza B, Shaheen R, Khan SA, Fatima F (2012) Serum homocysteine as a risk factor for coronary heart disease. J Ayub Med Coll Abbottabad 24:59–62
Google Scholar
Shenoy V, Mehendale V, Prabhu K, Shetty R, Rao P (2014) Correlation of serum homocysteine levels with the severity of coronary artery disease. Indian J Clin Biochem 29:339–344
Article
Google Scholar
Amiri Majd A, Rezaei M, Goodarzi M, Homayoonfar S (2007) Some biomarkers in acute myocardial infarction. J Res Health Sci 7:11–19
Google Scholar
Dayal S, Brown KL, Weydert CJ, Oberley LW, Arning E, Bottiglieri T, Faraci FM, Lentz SR (2002) Deficiency of glutathione peroxidase-1 sensitizes hyperhomocysteinemic mice to endothelial dysfunction. Arterioscler Thromb Vasc Biol 22:1996–2002
Article
Google Scholar