Fig. 2

Effect of sub-physiological temperatures on CSP translation. A Protein translation at physiological temperature where the concentration of non-CSPs increases while the CSPs remain at low levels. B The cellular response under cold shock involves modulation of protein expression where the concentration of CSPs increases while the non-CSPs diminishes. Reduced expression of non-CSPs is linked to repression of non-csp mRNA translation, leading to slower growth and cell cycle arrest. CSP overexpression is linked to higher csp-mRNA translation due to a secondary structure change that facilitates ribosome docking. CSP overexpression allows cell growth to continue under cold stress. CSP: cold-shock protein