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Table 1 Top gene ontology (GO) of OTGs. It is sorted on the basis of the smallest p value

From: Functional network analysis of p85 and PI3K as potential gene targets and mechanism of oleanolic acid in overcoming breast cancer resistance to tamoxifen

Term p value Genes
Biological process
 GO:0060337~type I interferon signaling pathway 5.29453E-07 SP100, IFI27, OAS1, OAS2, MX1, HLA-B, IFI6, HLA-C, IFIT1, HLA-G
 GO:0098609~cell-cell adhesion 1.94184E-05 SH3GLB2, LAD1, HSP90AB1, TACSTD2, CAPG, ENO1, RANGAP1, TMEM47, EIF2S3, EEF1D, EPB41L1, MYO6, TAGLN2, SPTAN1, SPTBN1, PICALM
 GO:0000122~negative regulation of transcription from RNA polymerase II promoter 0.000299991 SP100, RARG, IKZF1, PSEN1, RELA, SOX2, TPR, TBL1X, TAF9B, TFAP2A, TFAP2C, JUND, MSX2, H2AFY, DICER1, VEGFA, EID1, RBL1, BCL6, IFI27, NFIB, MDM2, TCF3, TRIM33, FGFR2
Cellular component
 GO:0005737~cytoplasm 1.63681E-08 IKZF1, ENO1, IFIT1, ACTB, SOX2, CDH1, NEK2, GLUL, MAP3K7, TNS3, TPD52, SH3GLB2, ACOT7, CDKL5, MBNL2, ADAM10, UBE4B, PPP4R3A, DICER1, ACLY, EID1, ARC, PRKAR1A, TRIM14, OBSL1, SKAP2, SET, MAX, STC1, GMPR, PIK3R1, DDX60, LPP, ZFP36L2, EPB41L1, EPB41L2, TPR, PSAP, MYO6, G3BP1, SOCS6, SPTBN1, SCAI, TFAP2A, PRNP, DTNA, GADD45B, CEP350, IFI44, EIF1, GULP1, EIF2S3, CAPRIN1, CDK2, MDM2, GNAS, NMT1, TCF3, FARSA, CDK13, FGFR2, FERMT2, RET, DAZAP2, ZCCHC11, RBM25, HSP90AB1, CITED1, LYST, BICD2, DUSP10, MECOM, GPER1, POLH, ZNF365, BTN3A3, KIF22, RANGAP1, ZDHHC17, DDX19A, OAS1, DNAJC7, SLC7A8, OAS2, HNRNPH1, EEF1D, TFF3, RAPGEF2, GART, MAPRE2, CD44, NFAT5, SP100, SRSF1, CAPG, TYMS, TANK, RELA, HSPD1, SH3BGRL, CCL5, SRSF10, PDLIM7, ARFGEF1, SPAG9, GSN, PLEKHA1, MX1, RANBP9, PTPN11, PSMB9, VEGFA, KITLG, XPNPEP1, CCNG2, ALMS1, FAS, MBTPS2
 GO:0070062~extracellular exosome 6.52789E-07 SERPINA3, LAD1, ZCCHC11, PATJ, SERPINA1, HSP90AB1, ITGB5, ABAT, ENO1, ACTB, EFEMP1, GM2A, CDH1, SMPD1, THSD7A, SPTAN1, GLUL, ACOT7, H2AFY, ATP6AP2, HLA-B, HPCAL1, HLA-C, ADAM10, RNASE4, ACLY, CLDN3, SLC7A8, DNAJC7, TFF3, B3GNT2, TAGLN2, DNASE2, ATP6V0D1, IL6ST, GART, S100A8, CD44, CFB, ATP6V1A, GRN, RALB, SRSF1, TACSTD2, CAPG, SLC1A4, HSPD1, SH3BGRL, EPB41L2, PSAP, MYO6, TSPAN3, SPTBN1, SPAG9, PRNP, SLC16A1, GSN, PLEKHA1, F12, LAMB1, RAB27B, PSMB9, GATM, EIF2S3, XPNPEP1, XPNPEP3, FAT1, GNAS, NUCB1, FAS, P4HB, CD22
 GO:0016020~membrane 2.55671E-06 RET, NRP1, HSP90AB1, IL1RAP, ENO1, ACTB, TM7SF2, FADS3, LAPTM4B, CDH1, SPTAN1, HLA-B, HPCAL1, DIO2, HLA-C, ADAM10, BTN3A3, SDHC, HLA-G, DDX19A, ACLY, SLC7A8, DNAJC7, PRKAR1A, OAS2, HNRNPH1, RAPGEF2, ATP6V0D1, ERGIC3, SEC22B, IL6ST, TACSTD2, RRBP1, SLC1A4, PSEN1, PIK3R1, HSPD1, AKAP1, ABR, UGCG, MYO6, GCNT2, PSMF1, SLC16A1, CEP350, C1GALT1, VEGFA, KITLG, G6PC3, PDE10A, GGCX, CAPRIN1, FAT1, GNAS, NUCB1, FAS, FARSA, FGFR2, PICALM
Molecular function
 GO:0005515~protein binding 9.49741E-11 PATJ, TRIO, TRRAP, IKZF1, ENO1, IFIT1, ACTB, SOX2, LAPTM4B, EFEMP1, TDO2, CDH1, NEK2, CCNL2, GLUL, MAP3K7, TNS3, TPD52, SH3GLB2, WSB1, ACOT7, MSX2, TPM1, HPCAL1, ADAM10, PRPF4B, DICER1, CDC25C, PRLR, ACLY, EID1, PRKAR1A, TAGLN2, RPP25, ATP6V0D1, IL6ST, OBSL1, S100A8, SKAP2, SET, MAX, TACSTD2, DAPP1, PSEN1, TRMT2B, PIK3R1, DDX60, LPP, ZFP36L2, STIP1, EPB41L1, TPR, PSAP, MYO6, G3BP1, PSMF1, SOCS6, SPTBN1, SCAI, TFAP2A, PLK4, PRNP, TFAP2C, DTNA, JUND, GADD45B, CEP350, ASPSCR1, SREK1IP1, RAB27B, FOXN3, PHC3, EIF2S3, BCL6, IL7, FUBP1, CDK2, MDM2, FAT1, GNAS, TCF3, FARSA, CDK13, CD22, FGFR2, FERMT2, PICALM, RET, SERPINA3, DAZAP2, NRP1, ZCCHC11, RARG, RBM25, SERPINA1, HSP90AB1, CITED1, ITGB5, CHD7, LYST, BICD2, WDR43, SPTLC1, MECOM, ZC3H7B, GPER1, SMPD1, C9ORF16, SPIN1, SPTAN1, POLH, RBM5, ZNF365, MSMB, SS18, HELLS, H2AFY, SECISBP2L, ATRX, ATP6AP2, KIF22, RANGAP1, ZDHHC17, DDX19A, SIKE1, RBL1, OAS1, DNAJC7, SLC7A8, OAS2, HNRNPH1, EEF1D, TFF3, RAPGEF2, SEC22B, MAPRE2, CD44, VAMP3, NFAT5, SP100, GRN, RALB, SRSF1, IFI6, CAPG, PBXIP1, TANK, RELA, HSPD1, AKAP1, RXRB, ERBB4, CCL5, TBL1X, TAF9B, SRSF10, PDLIM7, KCNJ3, MPZL2, ARFGEF1, SPAG9, GSN, PLEKHA1, F12, C1GALT1, MX1, SAMD4A, RANBP9, PTPN11, KLF3, PSMB9, VEGFA, KLF6, KITLG, ALMS1, NUCB1, FAS, P4HB, CYB561, TRIM33
 GO:0098641~cadherin binding involved in cell-cell adhesion 0.000107912 SH3GLB2, LAD1, HSP90AB1, CAPG, ENO1, RANGAP1, EIF2S3, CDH1, EEF1D, EPB41L1, MYO6, TAGLN2, SPTAN1, SPTBN1, PICALM
 GO:0042803~protein homodimerization activity 0.000523424 TFAP2A, TPD52, SP100, ACOT7, SLC16A1, CITED1, MAX, ADAM10, ABAT, TYMS, PRLR, HLA-G, RELA, VEGFA, MECOM, XPNPEP1, ERBB4, CCL5, TPR, TCF3, PSMF1, IL6ST, FGFR2, ZNF365