Table 1 Top gene ontology (GO) of OTGs. It is sorted on the basis of the smallest p value

 GO:0060337~type I interferon signaling pathway

5.29453E-07

SP100, IFI27, OAS1, OAS2, MX1, HLA-B, IFI6, HLA-C, IFIT1, HLA-G

 GO:0098609~cell-cell adhesion

1.94184E-05

SH3GLB2, LAD1, HSP90AB1, TACSTD2, CAPG, ENO1, RANGAP1, TMEM47, EIF2S3, EEF1D, EPB41L1, MYO6, TAGLN2, SPTAN1, SPTBN1, PICALM

 GO:0000122~negative regulation of transcription from RNA polymerase II promoter

0.000299991

SP100, RARG, IKZF1, PSEN1, RELA, SOX2, TPR, TBL1X, TAF9B, TFAP2A, TFAP2C, JUND, MSX2, H2AFY, DICER1, VEGFA, EID1, RBL1, BCL6, IFI27, NFIB, MDM2, TCF3, TRIM33, FGFR2

 GO:0005737~cytoplasm

1.63681E-08

IKZF1, ENO1, IFIT1, ACTB, SOX2, CDH1, NEK2, GLUL, MAP3K7, TNS3, TPD52, SH3GLB2, ACOT7, CDKL5, MBNL2, ADAM10, UBE4B, PPP4R3A, DICER1, ACLY, EID1, ARC, PRKAR1A, TRIM14, OBSL1, SKAP2, SET, MAX, STC1, GMPR, PIK3R1, DDX60, LPP, ZFP36L2, EPB41L1, EPB41L2, TPR, PSAP, MYO6, G3BP1, SOCS6, SPTBN1, SCAI, TFAP2A, PRNP, DTNA, GADD45B, CEP350, IFI44, EIF1, GULP1, EIF2S3, CAPRIN1, CDK2, MDM2, GNAS, NMT1, TCF3, FARSA, CDK13, FGFR2, FERMT2, RET, DAZAP2, ZCCHC11, RBM25, HSP90AB1, CITED1, LYST, BICD2, DUSP10, MECOM, GPER1, POLH, ZNF365, BTN3A3, KIF22, RANGAP1, ZDHHC17, DDX19A, OAS1, DNAJC7, SLC7A8, OAS2, HNRNPH1, EEF1D, TFF3, RAPGEF2, GART, MAPRE2, CD44, NFAT5, SP100, SRSF1, CAPG, TYMS, TANK, RELA, HSPD1, SH3BGRL, CCL5, SRSF10, PDLIM7, ARFGEF1, SPAG9, GSN, PLEKHA1, MX1, RANBP9, PTPN11, PSMB9, VEGFA, KITLG, XPNPEP1, CCNG2, ALMS1, FAS, MBTPS2

 GO:0070062~extracellular exosome

6.52789E-07

SERPINA3, LAD1, ZCCHC11, PATJ, SERPINA1, HSP90AB1, ITGB5, ABAT, ENO1, ACTB, EFEMP1, GM2A, CDH1, SMPD1, THSD7A, SPTAN1, GLUL, ACOT7, H2AFY, ATP6AP2, HLA-B, HPCAL1, HLA-C, ADAM10, RNASE4, ACLY, CLDN3, SLC7A8, DNAJC7, TFF3, B3GNT2, TAGLN2, DNASE2, ATP6V0D1, IL6ST, GART, S100A8, CD44, CFB, ATP6V1A, GRN, RALB, SRSF1, TACSTD2, CAPG, SLC1A4, HSPD1, SH3BGRL, EPB41L2, PSAP, MYO6, TSPAN3, SPTBN1, SPAG9, PRNP, SLC16A1, GSN, PLEKHA1, F12, LAMB1, RAB27B, PSMB9, GATM, EIF2S3, XPNPEP1, XPNPEP3, FAT1, GNAS, NUCB1, FAS, P4HB, CD22

 GO:0016020~membrane

2.55671E-06

RET, NRP1, HSP90AB1, IL1RAP, ENO1, ACTB, TM7SF2, FADS3, LAPTM4B, CDH1, SPTAN1, HLA-B, HPCAL1, DIO2, HLA-C, ADAM10, BTN3A3, SDHC, HLA-G, DDX19A, ACLY, SLC7A8, DNAJC7, PRKAR1A, OAS2, HNRNPH1, RAPGEF2, ATP6V0D1, ERGIC3, SEC22B, IL6ST, TACSTD2, RRBP1, SLC1A4, PSEN1, PIK3R1, HSPD1, AKAP1, ABR, UGCG, MYO6, GCNT2, PSMF1, SLC16A1, CEP350, C1GALT1, VEGFA, KITLG, G6PC3, PDE10A, GGCX, CAPRIN1, FAT1, GNAS, NUCB1, FAS, FARSA, FGFR2, PICALM

 GO:0005515~protein binding

9.49741E-11

PATJ, TRIO, TRRAP, IKZF1, ENO1, IFIT1, ACTB, SOX2, LAPTM4B, EFEMP1, TDO2, CDH1, NEK2, CCNL2, GLUL, MAP3K7, TNS3, TPD52, SH3GLB2, WSB1, ACOT7, MSX2, TPM1, HPCAL1, ADAM10, PRPF4B, DICER1, CDC25C, PRLR, ACLY, EID1, PRKAR1A, TAGLN2, RPP25, ATP6V0D1, IL6ST, OBSL1, S100A8, SKAP2, SET, MAX, TACSTD2, DAPP1, PSEN1, TRMT2B, PIK3R1, DDX60, LPP, ZFP36L2, STIP1, EPB41L1, TPR, PSAP, MYO6, G3BP1, PSMF1, SOCS6, SPTBN1, SCAI, TFAP2A, PLK4, PRNP, TFAP2C, DTNA, JUND, GADD45B, CEP350, ASPSCR1, SREK1IP1, RAB27B, FOXN3, PHC3, EIF2S3, BCL6, IL7, FUBP1, CDK2, MDM2, FAT1, GNAS, TCF3, FARSA, CDK13, CD22, FGFR2, FERMT2, PICALM, RET, SERPINA3, DAZAP2, NRP1, ZCCHC11, RARG, RBM25, SERPINA1, HSP90AB1, CITED1, ITGB5, CHD7, LYST, BICD2, WDR43, SPTLC1, MECOM, ZC3H7B, GPER1, SMPD1, C9ORF16, SPIN1, SPTAN1, POLH, RBM5, ZNF365, MSMB, SS18, HELLS, H2AFY, SECISBP2L, ATRX, ATP6AP2, KIF22, RANGAP1, ZDHHC17, DDX19A, SIKE1, RBL1, OAS1, DNAJC7, SLC7A8, OAS2, HNRNPH1, EEF1D, TFF3, RAPGEF2, SEC22B, MAPRE2, CD44, VAMP3, NFAT5, SP100, GRN, RALB, SRSF1, IFI6, CAPG, PBXIP1, TANK, RELA, HSPD1, AKAP1, RXRB, ERBB4, CCL5, TBL1X, TAF9B, SRSF10, PDLIM7, KCNJ3, MPZL2, ARFGEF1, SPAG9, GSN, PLEKHA1, F12, C1GALT1, MX1, SAMD4A, RANBP9, PTPN11, KLF3, PSMB9, VEGFA, KLF6, KITLG, ALMS1, NUCB1, FAS, P4HB, CYB561, TRIM33

 GO:0098641~cadherin binding involved in cell-cell adhesion

0.000107912

SH3GLB2, LAD1, HSP90AB1, CAPG, ENO1, RANGAP1, EIF2S3, CDH1, EEF1D, EPB41L1, MYO6, TAGLN2, SPTAN1, SPTBN1, PICALM

 GO:0042803~protein homodimerization activity

0.000523424

TFAP2A, TPD52, SP100, ACOT7, SLC16A1, CITED1, MAX, ADAM10, ABAT, TYMS, PRLR, HLA-G, RELA, VEGFA, MECOM, XPNPEP1, ERBB4, CCL5, TPR, TCF3, PSMF1, IL6ST, FGFR2, ZNF365