Table 2 Clinical, laboratory, and radiological data of the 2 groups of INS children

Age at sampling (years)

6.4±2.8

6.7±2.5

0.7

Sex: male/female

46/14

36/4

0.09

Age at diagnosis (years)

3.6±1.8

4.7±1.9

0.004

Duration of illness (months)

34.9±27.9

23.8±23.3

0.04

Family history: yes/no

5/55

2/38

0.7

Days to resolution of edema:

12.08±4.5

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Serum creatinine (mg/dl)

0.55±0.2

0.45±0.2

0.008

GFR (ml/min/1.73²)

116.5±52.8

164.7±48.5

<0.001

143.7±38.8

Serum albumin (g/dl)

1.8±0.3

3.5±0.9

<0.001

Serum cholesterol (mg/dl)

418.2±103.9

353.7±128.9

0.007

U pr/cr ratio

4.4±1.6

0.18±0.15

<0.001

Urinary sodium (mMol/L):

During edema: 20.9±8.6

36.5±10.5

<0.001

Resolved edema: 42.6±16.1

0.04

Hypertension (diagnosed before enrollment in study)

13 (21.7%)

5 (12.5%)

0.24

 1-Puffy eyes+ LL edema + ascites

25 (41.7%)

--------------

 2-As 1 + scrotal or vulval edema

30 (50%)

 3-1 or 2 + pleural effusion

5 (8.3%)

Types of NS:

<0.001

 Initial attack only:

32 (53.3%)

10 (25%)

 FRNS

4 (6.7%)

2 (5%)

 SDNS

4 (6.7%)

13 (32.5%)

 IFRNS

0

8 (20%)

 SRNS

20 (33.3%)

7 (17.5%)

Renal pathology:

0.07

 Not done

32 (53.3%)

30 (75%)

 MCD

9 (15%)

7 (17.5%)

 FPGN

5 (8.3%)

1 (2.5%)

 MN

4 (6.7%)

0

 FSGS

10 (16.7%)

2 (5%)

Plasma ANP (pg/ml):

During edema: 129.2±53.4

91.6±33.5

<0.001

Resolved edema:102.3±29.75

0.097