Jadavji NM, Wieske F, Dirnagl U, Winter C (2015) Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue. Mol Genet Metab Reports 3:1–4. https://doi.org/10.1016/j.ymgmr.2015.02.001
Article
Google Scholar
Novakovic B, Rakyan V, Ng HK, Manuelpillai U, Dewi C, Wong NC, Morley R, Down T, Beck S, Craig JM, Saffery R (2008) Specific tumour-associated methylation in normal human term placenta and first-trimester cytotrophoblasts. Mol Hum Reprod 14(9):547–554. https://doi.org/10.1093/molehr/gan046
Article
Google Scholar
Tanaka S, Nakanishi MO, Shiota K (2014) DNA methylation and its role in the trophoblast cell lineage. Int J Dev Biol 58(2-3-4):231–238. https://doi.org/10.1387/ijdb.140053st
Article
Google Scholar
Sinclair KD, Singh R (2007) Modelling the developmental origins of health and disease in the early embryo. Theriogenology 67(1):43–53. https://doi.org/10.1016/j.theriogenology.2006.09.017
Article
Google Scholar
Messerschmidt DM, Knowles BB, Solter D (2014) DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos. Genes Dev 28(8):812–828. https://doi.org/10.1101/gad.234294.113
Article
Google Scholar
Wu W, Shen O, Qin Y, Niu X, Lu C, Xia Y, Song L, Wang S, Wang X (2010) Idiopathic male infertility is strongly associated with aberrant promoter methylation of methylenetetrahydrofolate reductase (MTHFR). PLoS One 5(11):e13884. https://doi.org/10.1371/journal.pone.0013884
Article
Google Scholar
Biermann K, Steger K (2007) Epigenetics in male germ cells. J Androl 28(4):466–480. https://doi.org/10.2164/jandrol.106.002048
Article
Google Scholar
Lucas ES, Dyer NP, Murakami K, Hou Lee Y, Chan YW, Grimaldi G, Muter J, Brighton PJ, Moore JD, Patel G, Chan JKY, Takeda S, Lam EWF, Quenby S, Ott S, Brosens JJ (2016) Loss of endometrial plasticity in recurrent pregnancy loss. Stem Cells 34(2):346–356. https://doi.org/10.1002/stem.2222
Article
Google Scholar
Pliushch G, Schneider E, Weise D, El Hajj N, Tresch A, Seidmann L et al (2010) Extreme methylation values of imprinted genes in human abortions and stillbirths. Am J Pathol 176(3):1084–1090. https://doi.org/10.2353/ajpath.2010.090764
Article
Google Scholar
Dos Santos Nunes MK, Silva AS, De Queiroga Evangelista IW, Filho JM, Gomes CNAP, Do Nascimento RAF et al (2017) Hypermethylation in the promoter of the MTHFR gene is associated with diabetic complications and biochemical indicators. Diabetol Metab Syndr 9(1). https://doi.org/10.1186/s13098-017-0284-3
Ozdemir O, Silan F, Urfali M, Uludag A, Ari E, Kayatas M. Variable R.Msp1 fragmentation in genomic DNA due to DNA hypomethylation in CRF patients with MTHFR C677Tgene polymorphism: From genetics to epigenetics. Gene Ther Mol Biol 2014.
Miller SA, Dykes DD, Polesky HF (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16(3):1215. https://doi.org/10.1093/nar/16.3.1215
Article
Google Scholar
Antonaros F, Olivucci G, Cicchini E, Ramacieri G, Pelleri MC, Vitale L, Strippoli P, Locatelli C, Cocchi G, Piovesan A, Caracausi M (2019) MTHFR C677T polymorphism analysis: a simple, effective restriction enzyme-based method improving previous protocols. Mol Genet Genomic Med 7(5):e628. https://doi.org/10.1002/mgg3.628
Article
Google Scholar
Ng EKO, Leung CPH, Shin VY, Wong CLP, Ma ESK, Jin HC, Chu KM, Kwong A (2011) Quantitative analysis and diagnostic significance of methylated SLC19A3 DNA in the plasma of breast and gastric cancer patients. PLoS One 6(7):e22233. https://doi.org/10.1371/journal.pone.0022233
Article
Google Scholar
Khot VV, Yadav DK, Shrestha S, Kaur L, Sundrani DP, Chavan-Gautam PM, Mehendale SS, Chandak GR, Joshi SR (2017) Hypermethylated CpG sites in the MTR gene promoter in preterm placenta. Epigenomics 9(7):985–996. https://doi.org/10.2217/epi-2016-0173
Article
Google Scholar
Van Mil NH, Bouwl-Both MI, Stolk L, Verbiest MMPJ, Hofman A, Jaddoe VWV et al (2014) Determinants of maternal pregnancy one-carbon metabolism and newborn human DNA methylation profiles. Reproduction 148(6):581–592. https://doi.org/10.1530/REP-14-0260
Article
Google Scholar
Hanks J, Ayed I, Kukreja N, Rogers C, Harris J, Gheorghiu A, Liu CL, Emery P, Pufulete M (2013) The association between mthfr 677C>T genotype and folate status and genomic and gene-Specific dna methylation in the colon of individuals without colorectal neoplasia1-4. Am J Clin Nutr 98(6):1564–1574. https://doi.org/10.3945/ajcn.113.061432
Article
Google Scholar
Puri M, Kaur L, Walia GK, Mukhopadhhyay R, Sachdeva MP, Trivedi SS, Ghosh PK, Saraswathy KN (2013) MTHFR C677T polymorphism, folate, vitamin B12 and homocysteine in recurrent pregnancy losses: A case control study among north Indian women. J Perinat Med 0(0):1–6. https://doi.org/10.1515/jpm-2012-0252
Article
Google Scholar
Saraswathy K, Kaur L, Talwar S, Mishra J, Huidrom S, Sachdeva M, Puri M (2018) Methylenetetrahydrofolate reductase gene-specific methylation and recurrent miscarriages: A Case-Control Study from North India. J Hum Reprod Sci 11(2):142–147. https://doi.org/10.4103/jhrs.JHRS_145_17
Article
Google Scholar
Mishra J, Talwar S, Kaur L, Chandiok K, Yadav S, Puri M, Sachdeva MP, Lakshmy R, Saraswathy KN (2019) Differential global and MTHFR gene specific methylation patterns in preeclampsia and recurrent miscarriages: A case-control study from North India. Gene 704:68–73. https://doi.org/10.1016/j.gene.2019.04.036
Article
Google Scholar
Rotondo JC, Bosi S, Bazzan E, Di Domenico M, De Mattei M, Selvatici R et al (2012) Methylenetetrahydrofolate reductase gene promoter hypermethylation in semen samples of infertile couples correlates with recurrent spontaneous abortion. Hum Reprod 27(12):3632–3638. https://doi.org/10.1093/humrep/des319
Article
Google Scholar
Baylin SB, Herman JG (2000) DNA hypermethylation in tumorigenesis: Epigenetics joins genetics. Trends Genet 16(4):168–174. https://doi.org/10.1016/S0168-9525(99)01971-X
Article
Google Scholar
Settin A, Elshazli R, Salama A, Elbaz R (2011) Methylenetetrahydrofolate reductase gene polymorphisms in egyptian women with unexplained recurrent pregnancy loss. Genet Test Mol Biomarkers 15(12):887–892. https://doi.org/10.1089/gtmb.2011.0049
Article
Google Scholar
Khan R (2019) Association of MTHFR C677T with Idiopathic Recurrent Pregnancy Loss in Anhui Province of China. Int J Hum Genet 19(04). https://doi.org/10.31901/24566330.2019/19.04.01
Hwang KR, Choi YM, Kim JJ, Lee SK, Yang KM, Paik EC, Jeong HJ, Jun JK, Yoon SH, Hong MA (2017) Methylenetetrahydrofolate reductase polymorphisms and risk of recurrent pregnancy loss: a case-control study. J Korean Med Sci 32(12):2029–2034. https://doi.org/10.3346/jkms.2017.32.12.2029
Article
Google Scholar
Babker AMAAA, Gameel FEMH (2016) Methylenetetrahydrofolate reductase C677T polymorphism in sudanese women with recurrent spontaneous abortions. Kuwait Med J
Keyfi F, Ebrahimzadeh-Vesal R, Zhiyan N, Nayebi M, Nasseri M, Abbaszadegan MR (2018) The relationship between MTHFR polymorphisms and abortion in Iranian women. Gene Reports 13:130–133. https://doi.org/10.1016/j.genrep.2018.09.008
Article
Google Scholar
Mohammed SS, Al-Timimy RA, Hassan JN, Mahmood NT (2018) Association of The Mthfr C677t, Factor V (Leiden) G1961a and Prothrombin G20210a Gene Mutations with Recurrent Spontaneous Aboration (Rsa) in Duhok Province. Sci J Univ Zakho 6(3):85–88. https://doi.org/10.25271/sjuoz.2018.6.3.509
Article
Google Scholar
Zarfeshan Fard Y, Kooshkaki O, Kordi Tammandani D, Anani SG (2019) Investigation of the association between C677T polymorphism of the MTHFR gene and plasma homocysteine level in recurrent fetal miscarriage. J Obstet Gynaecol Res 45(8):1442–1447. https://doi.org/10.1111/jog.13989
Article
Google Scholar
Schmidl C, Delacher M, Huehn J, Feuerer M (2018) Epigenetic mechanisms regulating T-cell responses. J Allergy Clin Immunol 142(3):728–743. https://doi.org/10.1016/j.jaci.2018.07.014
Article
Google Scholar
Álvarez-Errico D, Vento-Tormo R, Ballestar E (2017) Genetic and epigenetic determinants in autoinflammatory diseases. Front Immunol 8. https://doi.org/10.3389/fimmu.2017.00318
La Rocca C, Carbone F, Longobardi S, Matarese G (2014) The immunology of pregnancy: regulatory T cells control maternal immune tolerance toward the fetus. Immunol Lett 162(1):41–48. https://doi.org/10.1016/j.imlet.2014.06.013
Article
Google Scholar
Foley DL, Craig JM, Morley R, Olsson CJ, Dwyer T, Smith K, Saffery R (2009) Prospects for epigenetic epidemiology. Am J Epidemiol 169(4):389–400. https://doi.org/10.1093/aje/kwn380
Article
Google Scholar
Feinberg AP (2007) Phenotypic plasticity and the epigenetics of human disease. Nature 447(7143):433–440. https://doi.org/10.1038/nature05919
Article
Google Scholar