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Table 3 The expected role of the miRNAs in hematopoiesis through their putative target genes (bold miR are validated)

From: Epigenetic effects toward new insights as potential therapeutic target in B-thalassemia

miRNA Target gene Predicted role in hematopoiesis Reference
miR-486-3p E2F1 Inhibits granulocytic proliferation and activity [25]
miR-15a
miR-16-1
cMyb • Drives MK differentiation
• Block DN3 to DN4 T-cell transition
• promotes differentiation of bi-potent K562 cells into MKs
• the forced expression of miR-15a in bone marrow mononuclear cells blocked the erythroid transition from BFU (erythroid burst-forming units) to CFU (erythroid colony-forming units)
[25, 32]
miR-15a
miR-16-1
miR-96
BCL2 • Modulate T cell development
• Regulation of positive selection by governing the homeostasis
[25]
miR-15a RUNX1 Highly expressed in megakaryocytopoiesis [33]
miR-486-3p
miR-96
FOXO3 Deprotect erythroid cells from oxidative stress [25]
miR-96
miR-16-1
CDK6 Prognostic marker for Mantle cell lymphoma [49]
miR-15a
miR-16-1
miR-486-3p
CCND1 Protect against Mantle cell lymphoma [49]
miR-96
miR-15a
ABL1 Involved in CML [35]
miR-96
miR-15a
KRAS Tumor suppressors [29]