Table 3 The expected role of the miRNAs in hematopoiesis through their putative target genes (bold miR are validated)
From: Epigenetic effects toward new insights as potential therapeutic target in B-thalassemia
miRNA | Target gene | Predicted role in hematopoiesis | Reference |
|---|---|---|---|
miR-486-3p | E2F1 | Inhibits granulocytic proliferation and activity | [25] |
miR-15a miR-16-1 | cMyb | • Drives MK differentiation • Block DN3 to DN4 T-cell transition • promotes differentiation of bi-potent K562 cells into MKs • the forced expression of miR-15a in bone marrow mononuclear cells blocked the erythroid transition from BFU (erythroid burst-forming units) to CFU (erythroid colony-forming units) | |
miR-15a miR-16-1 miR-96 | BCL2 | • Modulate T cell development • Regulation of positive selection by governing the homeostasis | [25] |
miR-15a | RUNX1 | Highly expressed in megakaryocytopoiesis | [33] |
miR-486-3p miR-96 | FOXO3 | Deprotect erythroid cells from oxidative stress | [25] |
miR-96 miR-16-1 | CDK6 | Prognostic marker for Mantle cell lymphoma | [49] |
miR-15a miR-16-1 miR-486-3p | CCND1 | Protect against Mantle cell lymphoma | [49] |
miR-96 miR-15a | ABL1 | Involved in CML | [35] |
miR-96 miR-15a | KRAS | Tumor suppressors | [29] |