Table 2 Selected MHC class-I allele, MHC class-II, and B cell binding peptides with their antigenicity scores and immunogenicity score to construct MESV
Protein | Peptide | Allele | Antigenicity | Immunogenicity |
|---|---|---|---|---|
MHC class-1 prM | YGVENVRVAY (187–196) | HLA-A*29:02 HLA-A*30:02 HLA-B*15:01 HLA-B*35:01 HLA-B*46:01 HLA-C*12:03 | 1.5 | 0.25 |
prM | FAVTALTIAY (252–261) | HLA-A*01:01 HLA-A*26:01 HLA-A*29:02 HLA-A*80:01 HLA-B*15:01 HLA-B*35:01 HLA-B*46:01 HLA-B*53:01 HLA-B*58:01 HLA-C*12:03 | 1.2 | 0.25 |
prM | LLVLAVGPAY (275–284) | HLA-A*26:01 HLA-A*29:02 HLA-A*30:02 HLA-B*15:01 HLA-B*15:02 HLA-B*35:01 | 0.7 | 0.12 |
E | GSQEVEFIGY (451–460) | HLA-A*01:01 HLA-A*30:02 | 1.1 | 0.44 |
E | QTAVDFGNSY (470–470) | HLA-A*01:01 HLA-A*25:01 HLA-A*26:01 HLA-A*30:02 HLA-B*15:01 | 1.1 | 0.11 |
MHC class-2 (E protein) | QTKIQYVIRAQLHVG (417–431) | HLA-DRB1*03:06 HLA-DRB1*08:01 HLA-DRB1*08:13 HLA-DRB1*08:17 HLA-DRB1*11:04 HLA-DRB1*11:20 HLA-DRB1*11:28 HLA-DRB1*13:05 HLA-DRB1*15:02 | 0.9 | 0.13 |
E | TKIQYVIRAQLHVGA (418–432) | HLA-DRB1*03:06 HLA-DRB1*04:21 HLA-DRB1*07:01 HLA-DRB1*07:03 HLA-DRB1*08:13 HLA-DRB1*08:17 HLA-DRB1*11:20 HLA-DRB1*11:28 HLA-DRB1*13:05 | 0.9 | 0.14 |
E | PPHAATIRVLALGNQ (521–535) | HLA-DRB1*08:06 HLA-DRB1*11:06 HLA-DRB1*13:07 HLA-DRB1*13:11 | 0.8 | 0.38 |
E | PHAATIRVLALGNQE (522–536) | HLA-DRB1*11:04 HLA-DRB1*11:06 HLA-DRB1*13:07 HLA-DRB1*13:11 | 0.8 | 0.28 |
E | AATIRVLALGNQEGS (524–538) | HLADRB1*11:04 HLA-DRB1*11:06 HLA-DRB1*13:07 HLA-DRB1*13:11 | 0.8 | 0.9 |
E | ATIRVLALGNQEGSL (525–539) | HLA-DRB1*11:06 HLA-DRB1*11:14 HLA-DRB1*13:07 HLA-DRB1*13:11 | 0.8 | 0.9 |
E | GAVLIWVGINTRNMT (743–757) | HLA-DRB1*03:09 HLA-DRB1*04:08 HLA-DRB1*08:17 HLA-DRB1*11:02 HLA-DRB1*11:04 HLA-DRB1*11:28 HLA-DRB1*13:05 HLA-DRB1*13:23 HLA-DRB1*15:02 | 1 | 0.52 |
E | AVLIWVGINTRNMTM (744–758) | HLA-DRB1*04:08 HLA-DRB1*04:21 HLA-DRB1*08:06 HLA-DRB1*11:02 HLA-DRB1*11:14 HLA-DRB1*11:28 HLA-DRB1*13:05 HLA-DRB1*13:23 HLA-DRB1*15:02 HLA-DRB5*01:05 | 1.1 | 0.49 |
E | VLIWVGINTRNMTMS (745–759) | HLA-DRB1*04:08 HLA-DRB1*04:21 HLA-DRB1*08:06 HLA-DRB1*08:17 HLA-DRB1*11:02 HLA-DRB1*11:14 HLA-DRB1*11:28 HLA-DRB1*13:05 HLA-DRB1*13:23 HLA-DRB5*01:01 | 1.2 | 0.30 |
B cell | HCIGITDRDFIEGVHG (287–302) | – | 1.2 | 0.76 |
NCPNLSPREEPDDI (169–182) | – | 1.4 | 0.07 | |
KVCYNAVLTHVKINDK (343–354) | – | 1.1 | 0.07 | |
AVMGDTAWDFSSAGGF (696–711) | – | 1.0 | 0.18 | |
VLIWVGINTRNMTMSM(745–760) | – | 1.2 | 0.16 |