Table 4 Constructed multi-epitope-based vaccine
Vaccine Construct | |
|---|---|
Adjuvant | 50S ribosomal protein |
EAAK | EAAAK |
B cell epitopes | WYYLNA |
LPSPSLKLGKKVAEAE | |
WYYLEAS | |
NKKLQLD | |
AELPSKIKAKLDAAFDQ | |
EQPQPAPAPQP | |
ERKVHYSIRKFSVGVASVVVASLVMGSVVHAT | |
SWYYLNA | |
SWYYLN | |
SWYYLNS | |
QWFKVSDKWYYVNGLGALAVNTT | |
LRELNVLED | |
Linker | CPGPG |
MHC-I epitopes | KVSDKWYYV |
RNYPTNTYK | |
TLIIKLSAI | |
SSNMAKTEYR | |
SNMAKTEYR | |
NANGAMATGW | |
QVATSSNMAK | |
LIIKLSAIK | |
TLIIKLSAIK | |
Linker | AAY |
MHC-II epitopes | SWYYLNANGAMATGW |
SWYYLNASGAMATGW | |
KWYYVNGLGALAVNT | |
GSWYYLNANGAMATG | |
GSWYYLNSNGAMATG | |
SWYYLNSNGAMATGW | |
WYYLNASGAMATGWA | |
WYYLNANGAMATGWL | |
WYYLNSNGAMATGWL | |
TWYYLEASGAMKASQ | |
VNGSWYYLNASGAMA | |
TLIIKLSAIKTEYLR | |
LIIKLSAIKTEYLRE | |
IKLSAIKTEYLRELN | |
KLSAIKTEYLRELNV | |
6X Histadine Tag | HHHHHH |