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Journal of Genetic Engineering and Biotechnology

Table 3 IEDB-predicted MHC-II-restricted epitope

From: In silico design of an epitope-based vaccine against PspC in Streptococcus pneumoniae using reverse vaccinology

No.

Peptide

All alleles

Antigenicity

Allergenicity

Toxicity

1

SWYYLNANGAMATGW

HLA-DRB1*01:01,HLA-DRB3*02:02,HLA-DRB1*13:02,HLA-DRB1*09:01,HLA-DRB1*04:01,HLA-DRB1*11:01,HLA-DQA1*05:01/DQB1*03:01,HLA-DQA1*01:02/DQB1*06:02,HLA-DRB5*01:01,HLA-DRB3*01:01,HLA-DRB1*04:05,HLA-DRB1*07:01

0.6068

Non-allergen

Non-toxin

2

SWYYLNASGAMATGW

HLA-DRB1*01:01,HLA-DRB3*02:02,HLA-DRB1*09:01,HLA-DRB1*11:01,HLA-DQA1*05:01/DQB1*03:01,HLA-DQA1*01:02/DQB1*06:02,HLA-DRB1*07:01,HLA-DRB1*13:02,HLA-DRB3*01:01,HLA-DRB1*04:01,HLA-DRB5*01:01,HLA-DRB1*04:05

0.502

Non-allergen

Non-toxin

3

KWYYVNGLGALAVNT

HLA-DRB1*01:01,HLA-DRB1*09:01,HLA-DRB3*02:02,HLA-DRB1*13:02,HLA-DPA1*03:01/DPB1*04:02,HLA-DRB5*01:01,HLA-DRB1*12:01,HLA-DQA1*05:01/DQB1*03:01,HLA-DRB1*04:05,HLA-DRB1*07:01,HLA-DRB1*04:01,HLA-DRB1*11:01,HLA-DPA1*01:03/DPB1*02:01,HLA-DQA1*01:02/DQB1*06:02

0.433

Non-allergen

Non-toxin

4

GSWYYLNANGAMATG

HLA-DRB1*01:01,HLA-DRB3*02:02,HLA-DRB1*13:02,HLA-DRB1*09:01,HLA-DRB1*04:01,HLA-DRB1*11:01,HLA-DRB3*01:01,HLA-DRB5*01:01,HLA-DQA1*05:01/DQB1*03:01,HLA-DRB1*04:05,HLA-DQA1*01:02/DQB1*06:02,HLA-DRB1*07:01,HLA-DRB1*15:01

0.6041

Non-allergen

Non-toxin

5

GSWYYLNSNGAMATG

HLA-DRB3*02:02,HLA-DRB1*01:01,HLA-DRB1*04:01,HLA-DRB1*09:01,HLA-DRB1*13:02,HLA-DRB1*11:01,HLA-DRB3*01:01,HLA-DRB1*04:05,HLA-DRB5*01:01,HLA-DRB1*07:01,HLA-DQA1*05:01/DQB1*03:01,HLA-DQA1*01:02/DQB1*06:02,HLA-DRB1*15:01

0.5133

Non-allergen

Non-toxin

6

SWYYLNSNGAMATGW

HLA-DRB3*02:02,HLA-DRB1*01:01,HLA-DRB1*13:02,HLA-DRB1*09:01,HLA-DRB1*04:01,HLA-DRB1*11:01,HLA-DRB3*01:01,HLA-DQA1*05:01/DQB1*03:01,HLA-DQA1*01:02/DQB1*06:02,HLA-DRB5*01:01,HLA-DRB1*07:01,HLA-DRB1*04:05

0.516

Non-allergen

Non-toxin

7

WYYLNASGAMATGWA

HLA-DRB1*01:01,HLA-DRB3*02:02,HLA-DRB1*09:01,HLA-DQA1*05:01/DQB1*03:01,HLA-DQA1*01:02/DQB1*06:02,HLA-DRB1*11:01,HLA-DRB1*07:01,HLA-DRB1*13:02,HLA-DRB3*01:01,HLA-DRB1*04:01,HLA-DRB5*01:01,HLA-DRB1*04:05

0.668

Non-allergen

Non-toxin

8

WYYLNANGAMATGWL

HLA-DRB1*01:01,HLA-DRB3*02:02,HLA-DRB1*13:02,HLA-DRB1*09:01,HLA-DQA1*05:01/DQB1*03:01,HLA-DRB1*04:01,HLA-DQA1*01:02/DQB1*06:02,HLA-DRB1*11:01,HLA-DRB5*01:01,HLA-DRB3*01:01,HLA-DRB1*07:01

0.5875

Non-allergen

Non-toxin

9

WYYLNSNGAMATGWL

HLA-DRB3*02:02,HLA-DRB1*01:01,HLA-DRB1*13:02,HLA-DRB1*09:01,HLA-DRB1*04:01,HLA-DRB1*11:01,HLA-DQA1*05:01/DQB1*03:01,HLA-DQA1*01:02/DQB1*06:02,HLA-DRB3*01:01,HLA-DRB5*01:01,HLA-DRB1*07:01

0.4967

Non-allergen

Non-toxin

10

TWYYLEASGAMKASQ

HLA-DRB1*01:01,HLA-DRB5*01:01,HLA-DRB1*09:01,HLA-DRB3*01:01,HLA-DRB1*07:01,HLA-DRB1*04:01,HLA-DQA1*01:02/DQB1*06:02,HLA-DQA1*05:01/DQB1*03:01,HLA-DRB1*13:02,HLA-DRB1*11:01,HLA-DRB1*04:05

0.734

Non-allergen

Non-toxin

11

VNGSWYYLNASGAMA

HLA-DRB1*09:01,HLA-DRB1*09:01,HLA-DRB3*02:02,HLA-DRB3*01:01,HLA-DRB1*07:01,HLA-DRB1*11:01,HLA-DRB1*13:02,HLA-DRB1*04:01,HLA-DRB5*01:01,HLA-DRB1*04:05,HLA-DQA1*05:01/DQB1*03:01

0.5358

Non-allergen

Non-toxin

12

TLIIKLSAIKTEYLR

HLA-DRB1*01:01,HLA-DRB4*01:01,HLA-DRB1*12:01,HLA-DRB1*09:01,HLA-DRB1*15:01,HLA-DRB5*01:01,HLA-DRB1*04:05,HLA-DRB1*13:02,HLA-DRB1*07:01,HLA-DRB1*08:02,HLA-DPA1*03:01/DPB1*04:02,HLA-DPA1*02:01/DPB1*05:01,HLA-DRB1*11:01,HLA-DRB1*04:01

0.5855

Non-allergen

Non-toxin

13

LIIKLSAIKTEYLRE

HLA-DRB1*01:01,HLA-DRB4*01:01,HLA-DRB1*12:01,HLA-DRB1*09:01,HLA-DRB1*04:05,HLA-DRB1*15:01,HLA-DRB5*01:01,HLA-DRB1*13:02,HLA-DRB1*07:01,HLA-DPA1*03:01/DPB1*04:02,HLA-DPA1*02:01/DPB1*05:01,HLA-DRB1*08:02,HLA-DPA1*02:01/DPB1*01:01,HLA-DRB1*04:01

0.5094

Non-allergen

Non-toxin

14

IKLSAIKTEYLRELN

HLA-DRB1*01:01,HLA-DRB4*01:01,HLA-DPA1*03:01/DPB1*04:02,HLA-DRB1*04:05,HLA-DRB1*15:01,HLA-DRB1*07:01,HLA-DRB1*09:01,HLA-DPA1*02:01/DPB1*01:01,HLA-DPA1*01:03/DPB1*04:01,HLA-DPA1*02:01/DPB1*05:01,HLA-DPA1*01:03/DPB1*02:01

0.7839

Non-allergen

Non-toxin

15

KLSAIKTEYLRELNV

HLA-DRB1*01:01,HLA-DPA1*03:01/DPB1*04:02,HLA-DRB4*01:01,HLA-DRB1*15:01,HLA-DRB1*07:01,HLA-DRB1*09:01,HLA-DPA1*01:03/DPB1*04:01,HLA-DPA1*02:01/DPB1*01:01,HLA-DPA1*01:03/DPB1*02:01,HLA-DPA1*02:01/DPB1*05:01

0.7314

Non-allergen

Non-toxin

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