Acetaminophen-traces bioremediation with novel phenotypically and genotypically characterized 2 Streptomyces strains using chemo-informatics, in vivo, and in vitro experiments for cytotoxicity and biological activity

Journal of Genetic Engineering and Biotechnology

Table 6 Anti-microbial activity monitored as growth inhibition % of isolated acetaminophen/paracetamol bio-degradation products in static or shaking states for M33 bacterial strain isolate

Microorganisms in culture suspension		M33-tested samples
Microorganisms in culture suspension		1a SH	1b ST
Gram negative	S. Arues	-ve	71.48
Gram negative	E. Coli	low	82.18
Gram positive	MRSA	81.89	low
	B. Subtills	-ve	-ve
	S. Typhi	-ve	-ve
Fungi	C. Albicans	-ve	-ve
Fungi	A. Niger	70.13	94.66

Values are the average of triplicate experiments
E. coli, Escherichia coli; S. typhi, Salmonella typhi; S. aureus, Staphylococcus aureus; MRSA, multidrug-resistant Staphylococcus aureus; B. subtilus, Bacillus subtilus; C. albicans, Candida albicans; A. niger, Aspergillus niger; 1a, M33 degradation products in shaking flask. 1b, M33 degradation products in a static flask. -ve, no inhibition zone appeared or less than 10% opaque media, if less than 50% inhibition = low activity, inhibition % = positive antimicrobial effect presented as clearance in the wells