Fig. 4

Representative photomicrographs of H&E-stained cerebral cortex of rats (scale bar = 50 µm). A Control and B Au-C. equisetifolia nano-extract-treated groups showing the normal histological architecture with intact neurons. C and D Toxic (CPF-intoxicated) group showing dark necrotic neurons (black arrow), neuronophagia (red arrow), and focal cerebral necrosis associated with proliferation of glial cells (black circle). E Au-C. equisetifolia nano-extract pre-treated group showing necrosis of sporadic neurons (black arrow) and neuronophagia (red arrow). F Au-C. equisetifolia nano-extract post-treated group showing necrosis of some neurons (black arrow)