Table 1 Identified 18 drug targets from the core genome of 119 S. Typhi along with their drug-like targets and virulent protein features
S. No. | Protein ID | Protein name | Drug | Virulent |
|---|---|---|---|---|
1 | WP_001125008.1 | Outer membrane usher protein | DB04147; DB04233 | VFG004229(gi:16759179) |
2 | WP_000705516.1 | Fimbrial outer membrane usher protein StdB | DB04147; DB04233 | VFG004286(gi:16761806) |
3 | WP_001034967.1 | TonB-dependent siderophore receptor | DB02415; DB04147 | VFG048511 (KOX_13890) |
4 | WP_000483273.1 | Methyl-accepting chemotaxis protein II | DB02365 | VFG043040(gi:16765261) |
5 | WP_000789682.1 | Methyl-accepting chemotaxis citrate transducer | DB02365 | VFG043209(gb|YP_001006778) |
6 | WP_000478457.1 | Methyl-accepting chemotaxis protein | DB02365 | VFG043092(gi:15802298) |
7 | WP_000094656.1 | PAS domain-containing methyl-accepting chemotaxis protein | DB02365 | VFG043209(gb|YP_001006778) |
8 | WP_000533850.1 | TolC family outer membrane protein | DB03350 | VFG034677(gi:387611073) |
9 | WP_000824321.1 | Porin OmpS2 | DB02771 | VFG043568(gi:16764916) |
10 | WP_000865526.1 | Porin OmpC | DB02415; DB04233 | VFG043568(gi:16764916) |
11 | WP_000475254.1 | Methyl-accepting chemotaxis protein | DB02365 | VFG043378(gb|NP_207394) |
12 | WP_001043666.1 | Phosphoporin PhoE | DB04233; DB07084 | VFG043568(gi:16764916) |
13 | WP_000088491.1 | Lipopolysaccharide 3-alpha-galactosyltransferase | DB02065; DB02976 | VFG013262(gi:148825462) |
14 | WP_000376863.1 | Lipopolysaccharide 1,2-glucosyltransferase RfaJ | DB02065; DB02976 | VFG013262(gi:148825462) |
15 | WP_000174482.1 | Lipoprotein insertase outer membrane protein LolB | DB02078 | VFG013621(gi:148826132) |
16 | WP_001024312.1 | YceI family protein | DB03232 | VFG043388(gi:15645899) |
17 | WP_000100805.1 | DNA starvation/stationary phase protection protein Dps | DB03754 | VFG006371(gi:15611298) |
18 | WP_000434523.1 | Thiosulfate sulfurtransferase GlpE | DB02761 | VFG044389(gi:6959513) |