Fig. 4

PfCSP domain organization and structure view. A Schematic model of the different PfCSP domains labeled as N-terminal domain, NANP repetition domain, and C-terminal domain. The figure also shows the Mosquirix PfCSP immunogen that shares structural similarities to PfCSP [20]. B Mass spectrometry observed a 3D model of the TSR domain of CSP displaying glycosylation location. Glycans are represented using sticks with green denoting carbon and red signifying oxygens. Silver carbons and blue nitrogens represent amino acid side chains attached to glycans. Yellow denotes disulfide bonds [43]. C Surface representation of how antibodies interact with PfCSP by binding to its NANP repeats to prevent sporozoites from invading hepatocytes [10]