Table 1 Binding energy of the selected T-cell and B-cell epitopes
Peptide-TLR complex | Peptide sequence | Binding energy (kcal/mol) | HLA allele | |
|---|---|---|---|---|
T-cell | VP24-TLR2 | 118IVHMLSEWLLLEVTS132 | − 9.6 | HLA-DRB1*01:01 |
GP-TLR5 | 579EERTFSLINRHAIDF593 | − 9.1 | HLA-DRB1*07:01 | |
RDRP-TLR4 | 366QQYCELFSLQKHWGH380 | − 11.5 | HLA-DRB1*11:01 | |
VP35-TLR5 | 1MWDSSYMQQVSEGLM15 | − 12.1 | HLA-DQA1*05:01 HLA-DQB1*02:01 | |
VP40-TLR5 | 112QFTHNGQKFVRVNRL126 | − 9.3 | HLA-DRB3*02:02 | |
B-cell | GP-TLR5 | 548LIKNQNNLVCRLRRLANQ565 | − 10.9 | --- |
RDRP-TLR4 | 1115FLRAYSWSDVLKGKRL1130 | − 13.5 | --- | |
RDRP-TLR5 | 1115FLRAYSWSDVLKGKRL1130 | − 9.8 | --- | |
VP35-TLR2 | 208LSAKDLALLLFTHLPGNNT226 | − 10.9 | --- | |
VP24-TLR2 | 104DQELQQSLIPGFRSIVHM121 | − 11.6 | --- |