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Table 1 Risk of bias assessment of included studies

From: Association between polymorphisms of immune response genes and early childhood caries — systematic review, gene-based, gene cluster, and meta-analysis

S. No

Author and Year

Ratio nale for study

Selection and definition of outcome of interest

Selection and comparability of comparison groups

Technical classification of the exposure

Non-technical classification of the exposure

Other sources of bias

Sample size and power

A priori planning of analyses

Statistical methods and control for confounding

Testing of assumptions and inferences for genetic analyses

Appropriateness of inferences drawn from results

Final Score

Qualit y of the study

1

Bagherian et al., 2008 [17]

6

5

5

3

1

1

1

5

5

3

6

41

Moder ate

2

Olszowski et al., 2012 [26]

6

5

5

5

1

1

5

5

5

5

6

49

Good

3

Briseño-Ruiz et al., 2013 [33]

6

5

5

4

1

1

3

6

6

4

6

47

Good

4

Krasone et al., 2013 [24]

6

5

5

1

1

1

1

6

1

3

6

36

Moderate

5

Yang et al., 2013 [27]

6

5

5

5

1

1

1

6

2

3

6

41

Moder ate

6

Mubayrik et al., 2014 [28]

6

6

5

4

1

1

1

5

4

5

6

44

Moder ate

7

Stanley et al., 2014 [34]

6

5

6

5

1

1

3

5

6

5

6

49

Good

8

Abbasoğlu et al., 2015 [18]

6

6

6

1

1

4

4

5

5

4

6

48

Good

9

Lips et al., 2017 [35]

6

6

5

5

1

1

1

6

6

5

6

48

Good

10

Wang et al., 2017 [25]

6

5

5

6

1

1

4

6

6

2

6

48

Good

11

Wang et al., 2018 [29]

6

5

5

5

1

1

6

6

6

3

6

50

Good

12

Weber et al., 2018 [36]

6

5

6

5

1

1

1

5

6

6

6

48

Good

13

Al-Marshad et al., 2021 [30]

6

6

5

3

1

1

5

5

5

6

6

49

Good

14

Zaorska et al., 2021 [31]

6

6

6

4

1

1

1

6

6

6

6

49

Good

15

Wu et al., 2022 [32]

5

6

6

4

1

1

5

5

5

5

6

49

Good