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Table 2 Oxidative stress status and viability of MCF-7 cells and CAT, LDH activities, and MDA production as a biomarker of lipid peroxidation

From: Adverse effect of Tamarindus indica and tamoxifen combination on redox balance and genotoxicity of breast cancer cell

Treatment at IC25 concentration

CAT

LDH

MDA production

Untreated cells

1.53 ± 0.13d

0.012 ± 0.0004d

0.46 ± 0.029e

T. indica extract

2.72 ± 0.39c

0.147 ± 0.007b

1.87 ± 0.18d

TAM

1.23 ± 0.09d

0.196 ± 0.018a

6.69 ± 0.64a

Extract + TAM

12.1 ± 0.06a

0.139 ± 0.008b

2.79 ± 0.28c

Extract +TAM + GSH

6.12 ± 0.85b

0.039 ± 0.002c

3.53 ± 0.35b

  1. The values represent the mean ± SD of three independent experiments. Values with different superscript letters within the same column indicate significant differences at P < 0.05. CAT and LDH activities were expressed as µmole/min/mg protein, and level of MDA production was expressed as µmol/mg protein. CAT, catalase; LDH, lactate dehydrogenase; MDA, malondialdehyde production