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Table 1 Level of GSH, and detoxification enzyme activities of MCF-7-treated cells

From: Adverse effect of Tamarindus indica and tamoxifen combination on redox balance and genotoxicity of breast cancer cell

Treatment with IC25 concentration

GSH

GPx

GR

GST

Untreated cells

0.096 ± 0.012d

0.380 ± 0.03c

0.095 ± 0.03b

0.47 ± 0.06d

T. indica extract

0.69 ± 0.034c

0.6 ± 0.26c

0.204 ± 0.01a

1.10 ± 0.02c

TAM

2.66 ± 0.024a

1.29 ± 0.40b

0.041 ± 0.005c

3.89 ± 0.43a

Extract + TAM

0.85 ± 0.21bc

1.56 ± 0.21a

0.245 ± 0.067a

1.11 ± 0.10c

Extract + TAM + GSH

1.03 ± 0.03b

1.68 ± 0.52a

0.207 ± 0.046a

1.57 ± 0.12b

  1. The values represent the mean ± SD of three independent experiments. Values with different superscript letters within the same column indicate significant differences at P < 0.05. GSH level was expressed as µmol/mg protein, and enzyme activities of GST, GPx, and GR were expressed as µmole/min/mg protein. GSH, reduced glutathione; GST, glutathione S-transferase; GPx, glutathione peroxidase; GR, glutathione reductase