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Table 4 IC50 of selected extracts exhibiting more than 60% cytotoxicity

From: Targeting apoptotic anticancer response with natural glucosinolates from cell suspension culture of Lepidium sativum

Extracts

IC50 (ug/ml)

 

MCF-7

pc3

A-549

caco2

HepG2

GRT

––

72.4 ± 0.8

92.6 ± 1.3

89.9 ± 2.6

61 ± 1.1

GL

––

59.7 ± 1.3

77.1 ± 0.7

56.6 ± 2.2

47.5 ± 1.9

GLM

––

51.4 ± 1.6

––

59.5 ± 2.3

38.5 ± 0.3

GLT

––

59.4 ± 2.1

––

68.7 ± 2.2

41.9 ± 0.8

OR

61 ± 0.9

66.2 ± 1.7

42.3 ± 1.1

72 ± 2.5

81.2 ± 0.7

OL

71.1 ± 1.4

54.4 ± 1.3

48 ± 0.7

63.6 ± 2.4

––

  1. Values = average ± standard deviation for tested extracts; GRT glucosinolates of root cell suspension treated with L-tyrosine, GL glucosinolates of leaf cell suspension, GLM glucosinolates of leaf cell suspension treated with L-methionine, GLT glucosinolates of leaf cell suspension treated with L-tyrosine, OR petroleum ether extract of root cell suspension, OL petroleum ether extract of leaf cell suspension