Association of CYP2R1 and CYP27B1 genes with the risk of obesity and vitamin D metabolism in Saudi women

AlSedairy, Sahar Abdulaziz; Al-Harbi, Laila Naif; Binobead, Manal Abdulaziz; Athinarayanan, Jegan; Arzoo, Shaista; Al-Tamimi, Dalia Saade; Shamlan, Ghalia; Alshatwi, Ali Abdullah; Periasamy, Vaiyapuri Subbarayan

doi:10.1186/s43141-023-00508-7

Journal of Genetic Engineering and Biotechnology

Table 3 Spearman correlations between sites of CYP27B1 methylation with different anthropometric and biochemical parameters

From: Association of CYP2R1 and CYP27B1 genes with the risk of obesity and vitamin D metabolism in Saudi women

Parameters (site 1)	R (SC)	Sig	Parameters (site 2)	R (SC)	Sig	Parameters (site 3)	R (SC)	Sig
Site 1 with wt^	0.116	0.187	Site 2 with wt^	0.103	0.242	Site 3 with wt^	0.123	0.163
Site 1 with BMI	0.061	0.486	Site 2 with BMI	0.095	0.282	Site 3 with BMI	0.095	0.281
Site 1 with waist	0.079	0.374	Site 2 with waist	0.112	0.204	Site 3 with waist	0.100	0.257
Site 1 with TC	0.040	0.649	Site 2 with TC	0.018	0.837	Site 3 with TC	− 0.010	0.908
Site 1 with TG	0.042	0.634	Site 2 with TG	0.051	0.564	Site 3 with TG	0.026	0.769
Site 1 with HDL	− 0.018	0.838	Site 2 with HDL	− 0.044	0.619	Site 3 with HDL	− 0.101	0.255
Site 1 with LDL	− 0.073	0.408	Site 2 with LDL	− 0.043	0.627	Site 3 with LDL	− 0.063	0.476
Site 1 with VD	− 0.060	0.542	Site 2 with VD	− 0.077	0.430	Site 3 with VD	− 0.181	0.062
Site 1 with PTH	0.042	0.639	Site 2 with PTH	0.030	0.741	Site 3 with PTH	0.064	0.475
Parameters (site 4)	R (SC)	Sig	Parameters (site 5)	R (SC)	Sig	Parameters (rotal)	R (SC)	Sig
Site 4 with wt^	0.093	0.292	Site 5 with wt^	0.068	0.443	Total with wt^	0.106	0.229
Site 4 with BMI	0.055	0.530	Site 5 with BMI	0.029	0.742	Total with BMI	0.066	0.454
Site 4 with waist	0.060	0.496	Site 5 with waist	0.022	0.800	Total with waist	0.075	0.396
Site 4 with TC	− 0.037	0.678	Site 5 with TC	− 0.061	0.486	Total with TC	− 0.002	0.984
Site 4 with TG	− 0.015	0.861	Site 5 with TG	0.030	0.733	Total with TG	0.029	0.742
Site 4 with HDL	− 0.059	0.509	Site 5 with HDL	− 0.090	0.313	Total with HDL	− 0.069	0.435
Site 4 with LDL	− 0.053	0.549	Site 5 with LDL	− 0.107	0.226	Total with LDL	− 0.074	0.404
Site 4 with VD	− 0.105	0.284	Site 5 with VD	− 0.192^a	0.047	Total with VD	− 0.153	0.116
Site 4 with PTH	0.124	0.165	Site 5 with PTH	− 0.045	0.611	Total with PTH	0.047	0.598

SC Spearman correlation, wt^ weight
^a Correlation is significant at the 0.05 level

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