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Journal of Genetic Engineering and Biotechnology
Fig. 1 | Journal of Genetic Engineering and Biotechnology

Fig. 1

From: Therapeutic impact of purified Trichoderma viride l-asparaginase in murine model of liver cancer and in vitro Hep-G2 cell line

Fig. 1

Liver section from a control rat group showed normal hepatocyte cells before (A) and after (B) l-asparaginase treatment (non-significant change with respect to control); b treated rat (C&C*) given diethyl nitrosamine DENA (chemotoxic agent) showed enlarged hyperchromatic nuclei with scattered mitosis, massive focal necrosis cirrhosis in hepatic parenchyma cells with inflammatory cells infiltration surrounding the dilated portal vein and sinusoidal dilatation and congestion; c cirrhotic rat treated l-asparaginase (D&D*) showed significant regression of hepatic fibrosis, reduced sinusoidal dilatation and congestion, restoration of most of the normal hepatocyte architecture with regular dark nuclei

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