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Table 4 Effects of Q3G-RF from S. mombin leaves on some parameters of diarrhoea in magnesium sulphate model of Wistar rats

From: Quercetin-3-O-β-D-glucopyranoside-rich fraction demonstrated efficacy against infectious, secretory, and osmotic models of diarrhoeal rats

 

Non-diarrhoeal

Diarrhoel rats (1 mL of magnesium sulphate)

Normal saline

Normal saline

Loperamide

Q3G-RF from S. mombin leaves (mg/kg body weight)

1 mL

1 mL

3 mg/kg body weight

100

200

400

Onset time (minutes)

50.67 ± 1.04

55.98 ± 1.04b

120.55 ± 1.15#

74.65 ± 1.07#

120.59 ± 1.19#

> longest time the experiment lasted

Total number of faeces

1.00 ± 1.01

6.60 ± 1.02b

2.00± 0.05#

3.00 ± 0.07#

2.60 ± 0.06#

1.90 ± 0.01#

Number of wet faeces

0.10 ± 0.02

4.40 ± 0.03b

0.60 ± 0.03#

1.50 ± 0.02#

0.60 ± 0.04#

-

Fresh weight of faeces (g)

0.15 ± 0.10

3.98 ± 0.07b

0.55 ± 0.01#

0.90 ± 0.02#

0.67 ± 0.95#

-

Water content of aces (mL

0.01 ± 0.00

1.59 ± 0.01b

0.33 ± 0.04#

0.99 ± 0.08#

0.47 ± 0.11#

-

Inhibition of defecation (%)

-

0

85

64

86

100

  1. Values are mean of 6 replicates ± SEM, significant differences from the sham control group are indicated by b and from negative control by #, p < 0.05