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Table 3 Some parameters of diarrhoea modulated by Q3G-RF from S. mombin leaves in castor oil model of Wistar rats

From: Quercetin-3-O-β-D-glucopyranoside-rich fraction demonstrated efficacy against infectious, secretory, and osmotic models of diarrhoeal rats

 

Non-diarrhoeal

Diarrhoel rats (1 mL of castor oil)

Normal saline

Normal saline

Loperamide

Q3G-RF from S. mombin leaves (mg/kg body weight)

1 mL

1 mL

3 mg/kg body weight

100

200

400

Onset time (minutes)

54.45 ± 1.01

58.15 ± 1.05b

121.78 ± 1.80#

75.68 ± 1.17#

92.19 ± 1.19#

128.77 ± 1.82#

Total number of faeces

1.10 ± 0.11

5.80 ± 0.15b

2.00± 0.12#

3.90 ± 0.17#

2.80 ± 0.16#

2.00 ± 1.10#

Number of wet faeces

0.10 ± 0.03

5.10 ± 0.13b

0.70 ± 0.03#

1.60 ± 0.02#

0.90 ± 0.04#

0.70 ± 0.02#

Fresh weight of faeces (g)

0.19 ± 0.10

3.59 ± 0.11b

0.51 ± 0.07#

2.11 ± 0.10#

0.90 ± 0.05#

0.58 ± 0.05#

Water content of faeces (mL)

0.02 ± 0.00

1.88 ± 0.01b

0.41 ± 0.04#

1.01 ± 0.08#

0.67 ± 0.11#

0.45 ± 0.03#

Inhibition of defecation (%)

-

0

85

67

80

86

  1. Values are mean of 6 replicates ± SEM, significant differences from the sham control group are indicated by b and from negative control by #, p < 0.05