Fig. 6
From: Gold nanoparticles combined baker’s yeast as a successful approach for breast cancer treatment
Mammary gland tissue of A control female rats showing ordinary benign mammary duct lined by benign double epithelium and myoepithelium (thick black arrow), surrounded by thin eosinophilic connective tissue (thin black arrow) amidst fat cells (white arrow). B–G DMBA-injected rats showing: B DCIS cribriform pattern (black arrowheads). C Intraductal carcinoma (black arrowheads). D, E Pleomorphic, cellular, spindle, and fusiform tumorous cell proliferation with numerous mitoses (white triangles); some being abnormal. F Spindle and fusiform tumorous cell proliferation invading in between muscle bundles (black arrowheads). G Tubular tumorous proliferation (blue arrowheads) lined by atypical epithelial cells with intervening fusiform and spindle cells. H Yeast-injected rats showing residual hyperplasia within mammary ductal epithelial lining (thick black arrows). No tumor. I Nanogold carrying yeast-injected rats showing mammary ducts with benign, regular linings approximating control (thick black arrows). No tumor (H&E × 200)