Fig. 5
From: Gold nanoparticles combined baker’s yeast as a successful approach for breast cancer treatment
Mammary gland tissue of A control female rats shows ordinary benign mammary ducts lined by benign double epithelium and myoepithelium (thick black arrow), surrounded by thin eosinophilic connective tissue (thin black arrow) amidst fat cells (white arrow). B–G DMBA-injected rats showing B DCIS cribriform and clinging patterns (black arrowheads) with mixed inflammatory cell aggregates (a black star) within surrounding tissues. C intraductal carcinoma (black arrowheads). D Cellular, spindle, and fusiform cell proliferation (black arrowheads). E Spindle and fusiform tumorous cell proliferation invading in between muscle bundles (black arrowheads). F Cellular, spindle cell tumorous proliferation with several mitoses (white triangles). G Tubular tumorous proliferation (blue arrowheads) lined by atypical epithelial cells with intervening fusiform and spindle cells. H, I Yeast-injected rats showing residual atypical hyperplasia within mammary ductal epithelial lining (thick black arrows). I Nanogold carrying yeast injected rats showing mammary ducts with benign lining approximating control (thick black arrows). No tumor (H&E × 100)