Table 6 Predicted consensus GO terms for homology modeled ORF2 structures

  GO:0005198~structural molecule activity

The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

  GO:0043167~ion binding

Binding to an ion, a charged atoms or groups of atoms.

  GO:0005975~carbohydrate metabolic process

The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

  GO:0006955~immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

  GO:0006935~chemotaxis

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

  GO:0006260~DNA replication

The cellular metabolic process in which a cell duplicates one or more molecules of DNA.

  GO:0034638~phosphatidylcholine catabolic process

The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.

  GO:0005198~structural molecule activity

The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

  GO:0043167~ion binding

Binding to an ion, a charged atoms or groups of atoms.

  GO:0022900~electron transport chain

A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors.

  GO:0006810~transport

The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein.

  GO:0019079~viral genome replication

Any process involved directly in viral genome replication, including viral nucleotide metabolism.

  GO:0032774~RNA biosynthetic process

The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication.

  GO:0006221~pyrimidine nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.

  GO:0005198~structural molecule activity

The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

  GO:0016638~oxidoreductase activity, acting on the CH-NH2 group of donors

Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.

  GO:0046872~metal ion binding

Binding to a metal ion.

  GO:0051536 ~ iron-sulfur cluster binding

Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.

  GO:0009084~glutamine family amino acid biosynthetic process

The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.

  GO:0006536~glutamate metabolic process

The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.

  GO:0005198~structural molecule activity

The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

  GO:0043167~ion binding

Binding to an ion, a charged atoms or groups of atoms.

  GO:0051234~establishment of localization

Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.

  GO:0005198~structural molecule activity

The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

  GO:0043167~ion binding

Binding to an ion, a charged atoms or groups of atoms.

  GO:0051234~establishment of localization

Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.

  GO:0005198~structural molecule activity

The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

  GO:0043167~ion binding

Binding to an ion, a charged atoms or groups of atoms.

  GO:0051234~establishment of localization

Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.

  GO:0005198~structural molecule activity

The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

  GO:0016726~oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

  GO:0016727~oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule.

  GO:0046914~ transition metal ion binding

Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.

  GO:0051536~iron-sulfur cluster binding

Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.

  GO:0006145~purine nucleobase catabolic process

The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.

  GO:0046110~xanthine metabolic process

The chemical reactions and pathways involving xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.

  GO:0005198~structural molecule activity

The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

  GO:0051540~metal cluster binding

Binding to a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters.

  GO:0016726~oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

  GO:0016727~oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule.

  GO:004280~identical protein binding

Binding to an identical protein or proteins.

  GO:0046914~transition metal ion binding

Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.

  GO:0007589~body fluid secretion

The controlled release of a fluid by a cell or tissue in an animal.

  GO:0030855~epithelial cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.

  GO:0045595~ regulation of cell differentiation

Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.

  GO:0006145~purine nucleobase catabolic process

The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.

  GO:2000026~regulation of multicellular organismal development

Any process that modulates the frequency, rate or extent of multicellular organismal development.