Table 2 The predicted percentage of intrinsic disorder scores of the ORF2 protein in hepatitis E viruses

[1-4]

MRPR

[21-40]

PPGQPSGRRRGRRSGGSGGG

[65-123]

VTAAAGAGPRVRQPVRPLGSAWRDQAQRPAAASRRRPTTAGAAPLT AVAPAHDTPPVPD

[131-156]

LRRQYNLSTSPLTSSVATGTNLVLYA

[167-181]

DGTNTHIMATEASNY

[186-198]

VARATIRYRPLVP

[219-245]

TSVDMNSVTSTGVRILVQPGIASELVI

[257-289]

WRPVETSGVAEEEATSGLVMLCIHGSPVNSYTN

[316-331]

NTRVSRYSSTARHRLR

[407-412]

PTVKLY

[424-428]

IAIPH

[444-454]

NQHEQDRPTPS

[456-456]

A

[484-502]

YGSSTGPVYVSDSVTLVDD

[577-602]

RVAISTYTTSLGAGPVSISAVAVLDD

[655-655]

K

[657-659]

REL

43.25

17

59

[1-56]

MRPRPILLLFLMFLPMLPAPPPGQPSGRRRGRRSGGSGGGFWGDRVDSQPFAPYIH

[65-132]

VTAAAGAGPRVRQPVRPLGSAWRDQAQRPAAASRRRPTTAGAAPLTAVAPAHDTPPVPDVDSRGAILR

[316-338]

NTRVSRYSSTARHRLRRGADGTA

[433-462]

GESRVVIQDYDNQHEQDRPTPSPAPSRPFS

[649-659]

LKMKVGKTREL

28.53

5

68

[1-132]

MRPRPILLLFLMFLPMLPAPPPGQPSGRRRGRRSGGSGGGFWGDRVDSQPFAPYIHPTNPFAPDVTAAAGAGPRVRQPVRPLGSAWRDQAQRPAAASRRRPTTAGAAPLTAVAPAHDTPPVPDVDSRGAILR

[134-134]

Q

[136-145]

NLSTSPLTSS

[216-225]

PTPTSVDMNS

[263-269]

SGVAEEE

[311-341]

TPGNTNTRVSRYSSTARHRLRRGADGTAELT

[440-462]

QDYDNQHEQDRPTPSPAPSRPFS

[480-491]

DQSTYGSSTGPV

[651-659]

MKVGKTREL

35.66

9

132

[1-44]

MRPRPILLLFLMFLPMLPAPPPGQPSGRRRGRRSGGSGGGFWGD

[69-71]

AGA

[73-115]

PRVRQPVRPLGSAWRDQAQRPAAASRRRPTTAGAAPLTAVAPA

[120-121]

PV

[218-219]

PT

[448-458]

QDRPTPSPAPS

[603-618]

HSALALLEDTLDYPAR

[647-659]

QRLKMKVGKTREL

20.33

134

45

[1-5]

MRPRP

[21-40]

PTGQPSGRRRGRRSGGTGGG

[64-123]

DVAAASGSGPRLRQPARPLGSTWRDQAQRPSAASRRRPATAGAAALTAVAPAHDTSPVP

[132-182]

LRRQYNLSTSPLTSSVASGTNLVLYAAPLNPPLPLQDGTNTHIMATEASNY

[187-199]

VARATIRYRPLVP

[223-246]

DMNSITSTDVRILVQPGIASELVI

[259-290]

RSVETSGVAEEEATSGLVMLCIHGSPVNSYTN

[321-336]

SRYSSTARHSARGADG

[407-412]

PTVKLY

[446-454]

HEQDRPTPS

[456-456]

A

[486-502]

SSTGPVYISDSVTLVNV

[581-602]

STYTTRLGAGPVAISAAAVLAP

[649-659]

LKVKVGKTREL

43.55

14

60

[1-50]

MRPRPLLLLFLLFLPMLPAPPTGQPSGRRRGRRSGGTGGGFWGDRVDSQP

[67-146]

AAASGSGPRLRQPARPLGSTWRDQAQRPSAASRRRPATAGAAALTAVAPAHDTS PVPDVDSRGA ILRRQYNLST SPLTSS

[431-460]

DLGDSRVVIQDYDNQHEQDRPTPSPAPSRP

[654-659]

GKTREL

25.19

4

80

[1-150]

MRPRPLLLLFLLFLPMLPAPPTGQPSGRRRGRRSGGTGGGFWGDRVDSQPFAIPYIHPTNPFAPDVAAASGSGPRLRQPARPLGSTWRDQAQRPSAASRRRPATAGAAALTAVAPAHDTSPVPDVDSRGAILRRQYNLSTSPLTSSVASG

[165-167]

PLQ

[219-226]

PTSVDMNS

[263-270]

TSGVAEEE

[316-342]

TNTRVSRYSSTARHSARGADGTAELTT

[432-432]

L

[435-436]

SR

[439-462]

IQDYDNQHEQDRPTPSPAPSRPFS

[481-490]

QSTYGSSTGP

[652-659]

KVGKTREL

36.57

10

150

[1-39]

MRPRPLLLLFLLFLPMLPAPPTGQPSGRRRGRRSGGTGG

[69-116]

ASGSGPRLRQPARPLGSTWRDQAQRPSAASRRRPATAGAAALTAVAPA

[118-123]

DTSPVP

[132-135]

LRRQ

[217]

T

[219-220]

PT

[222]

V

[359]

G

[453]

P

[455-456]

PA

[603-618]

RSALALLEDTFDYPGR

[647-659]

QRLKVKVGKTREL

20.48

135

48

[1-2]

MR

[19-40]

AGQPSGRRRGRRSGGAGGG

[69-125]

QSGAGARPRQPPRPLGSAWRDQ SQRPSAPPRRQRSTPAGAAPLTAISPAPDTAPVPDV

[132-179]

LRRQYNLSTSPLTSSVASGTNLVLYAAPLNPLLPLQDGTNTHIMATEA

[188-199]

VRATIRYRPLVP

[223-246]

DMNSITSTDVRILVQPGIASELVI

[259-290]

RSVETTGVAEEEATSGLVMLCIHGSPVNSYTN

[318-332]

TRVSRYTSTARHRLR

[408-413]

PTVKLY

[447-455]

HEQDRPTPS

[457-457]

A

[579-609]

VAISTYTTSLGAGPTSISAVGVLAPHSALAV

[654-660]

VGKTRES

40.30

13

57

[1-46]

MRPGAVLLLLLVFLPMLPAPPAGQPSGRRRGRRSGGAGGGFWGDRV

[65-140]

DVVSQSGAGARPRQPPRPLGSAWRDQSQRPSAPPRRRSTPAGAAPLTAISPAPDTAPVPDVDSRGAILRRQYNLST

[318-343]

TRVSRYTSTARHRLRRGADGTAELTT

[432-461]

DLGDSRVVIQDYDNQHEQDRPTPSPAPSRP

[651-660]

KMKVGKTRES

28.48

5

76

[1-56]

MRPGAVLLLLLVFLPMLPAPPAGQPSGRRRGRRSGGAGGGFWGDRVDSQPFALPYI

[58-148]

PTNPFVADVVSQSGAGARPRQPPRPLGSAWRDQSQRPSAPPRRRSTPAGAAPLTAISPAPDTAPVPDVDSRGAILRRQYNLSTSPLTSSVA

[218-226]

TPTSVDMNS

[265-270]

GVAEEE

[312-344]

PGNTNTRVSRYTSTARHRLRRGADGTAELTTT

[433-463]

LGDSRVVIQDYDNQHEQDRPTPSPAPSRPFS

[484-484]

T

[486-491]

YGSSTNP

[589-591]

GAG

[652-660]

MKVGKTRES

37.12

10

91

[1-41]

MRPGAVLLLLLVFLPMLPAPPAGQPSGRRRGRRSGGAGGGF

[70-117]

SGAGARPRQPPRPLGSAWRDQSQRPSAPPRRRSTPAGAAPLTAISPAP

[123]

V

[449-458]

QDRPTPSPAP

[605-618]

SALAVLEDTADYPA

[657-660]

LQRLKMKVGKTRES

19.39

128

48

[32-54]

PAPPAGQPSGRRRGRRSSGTGGG

[80-139]

ISTAAGAGARPRQPARPLGSAWRDQSQRPAASSRRRSAPAGASPLTAVAPAPDTAPVPDI

[147-196]

RRQYNLSTSPLTST IATGTNLVLYAAPLSPLLPLQDGTNTHIMATEASNY

[201-213]

VARATIRYRPLVP

[237-260]

DMNSITSTDVRILVQPGIASELVI

[273-304] RSVETSGVAEEEATSGLVMLCIHGSPVNSYTN

[331-352]

NTRVSRYSSSARHKLRRGPDGT

[422-427]

PTVKLY

[439-443]

IAIPH

[459-469]

NQHEQDRPTPS

[471-471]

A

[598-619]

YTTNLGSGPVSISAVGVLAPHS

[674-674]

Y

40.06

13

60

[22-62]

FLLLVLLPMLPAPPAGQPSGRRRGRRSSGTGGGFWGDRVDS

[81-144]

STAAGAGARPRQPARPLGSAWRDQSQRPAASSRRRSAPAGASPLTAVAPA PDTAPVPDIDSRGA

[330-358]

TNTRVSRYSSSARHKLRRGPDGTAELTTT

[448-475]

GESRVVIQDYDNQHEQDRPTPSPAPSRP

24.04

4

64

[1-6]

MNNMFS

[23-25]

LLL

[28-158]

LPMLPAPPAGQPSGRRRGRRSSGTGGGFWGDRVDSQPFALPYIHPTNPFASDISTAAGAGARPRQPARPLGSAWRDQSQRPAASSRRRSAPAGASPLTAVAPAPDTAPVPDIDSRGAILRRQYNLSTSPLT

[233-240]

PTSVDMNS

[277-284]

TSGVAEEE

[326-357]

TPGNTNTRVSRYSSSARHKLRRGPDGTAELTTT

[455-476]

QDYDNQHEQDRPTPSPAPSRPF

[500-505]

GSSTNP

[667-674]

KVGKTREY

33.23

9

131

[1-53]

MNNMFSCSVHGDATMRSRALLFLLLVLLPMLPAPPAGQPSGRRRGRRSSGTGG

[83-130]

AAGAGARPRQPARPLGSAWRDQSQRPAASSRRRSAPAGASPLTAVAPA

[133-135]

TAP

[463-472]

QDRPTPSPAP

[619-633]

SVLAALEDTVDYPAR

[661-674]

LQRLKMKVGKTREY

21.22

143

53

[26-54]

VLLPMLPAPPAGQSSGRRRGRRSGGAGSG

[85-140]

GTGARSRQSARPLGSAWRDQTQRPPAASRRRSTPTGASPLTAVAPAPDTRPVPDVD

[142-142]

R

[145-193]

ILRRQYNLSTSPLTSTIASGTNLVLYAAPLSPLLPLQDGTNTHIMATEA

[202-213]

VRATIRYRPLVP

[236-260]

VDMNSITSTDVRIVVQPGLASELVI

[273-304]

RSVETSGVAEEEATSGLVMLCIHGSPVNSYTN

[331-344]

NTRVSRYSSTARHR

[422-427]

PTVKLY

[461-469]

HEQDRPTPS

[597-618]

TYTTSLGSGPVSVSGVGVLAPH

[665-670]

KMRVGK

[672-672]

R

[674-674]

F

39.02

14

56

[27-60]

LLPM LPAPPAGQSSGRRRGRRSGGAGSGFWGDRV

[84-151]

TGTGARSRQSARPLGSAWRDQTQRPPAASRRRSTPTGASPLTAVAPA PDTRPVPDVDSRGAILRRQYN

[333-354]

RVSRYSSTARHRLHRGADGTAE

[449-472]

DSRVVIQDYDNQHEQDRPTPSPAP

[673-674]

EF

22.26

5

68

[1-2]

MN

[32-161]

PAPPAGQSSGRRRGRRSGGAGSGFWGDRVDSQPFALPYIHPTNPFASDTIAATGTGARSRQSARPLGSAWRDQTQRPPAASRRRSTPTGASPLTAVAPAPDTRPVPDVDSRGAILRRQYNLSTSPLTSTIASGTNLVLYAAPLSPLLPLQDGTNTHIMATEA

[232-240]

TPTSVDMNS

[277-284]

TSGVAEEE

[327-357]

PGNTNTRVSRYSSTARHRLHRGAD

[455-476]

QDYDNQHEQDRPTPSPAPSRPF

[501-504]

TSTD

[602-608]

LGSGPVS

[668-674]

VGKTREF

32.64

9

130

[1-55]

MNNMFLCFACGYATMRPRAILLLLVVLLPMLPAPPAGQSSGRRRGRRSGGAGSGF

[84-86]

TGT

[89-237]

RSRQSARPLGSAWRDQTQRPPAASRRRSTPTGASPLTAVAPAPDTRPVP

[462-472]

EQDRPTPSPAP

[618-633]

HAALAVLEDTVDYPAR

[662-674]

QRLKMRVGKTREF

21.81

147

55

[1-2]

MR

[18-40]

PAPPAGQPSGRRRGRRSGGSGGG

[66-67]

VS

[69-125]

SAGAGARARQAARPLGSAWRDQSQRPSASARRRPTPAGASPLTAVAPAPDTTPVPDV

[132-179]

LRRQYNLSTSPLTSTVASGTNLVLYAAPLGPLLPLQDGTNTHIMATEA

[188-199]

IRATIRYRPLVP

[223-246]

DMNSITSTDVRILVQPGLASELII

[259-290]

RSVETSGVAEEEATSGLVMLCIHGSPVNSYTN

[318-332]

TRVSRYTSTARHRLR

[408-413]

PTVKLY

[424-430]

GIAIPHE

[446-455]

QHEQDRPTPS

[582-612]

STYTTNLGSGPVSISAVGVLAPHAATAALED

[652-656]

MKVGK

[658-660]

REF

41.97

15

57

[1-52]

MRPRAVLLLFLMLLPMLPAPPAGQPSGRRRGRRSGGSGGGFWGDRVDSQPFA

[68-138]

TSAGAGARARQAARPLGSAWRDQSQRPSASARRRPTPAGASPLTAVAPAPDTTPVPDVDSRGAILRRQYNL

[317-341]

NTRVSRYTSTARHRLRRGPDGTAE L

[432-459]

DLGDSRVTIQDYDNQHEQDRPTPSPAPS

[659-660]

EF

26.97

5

71

0.3317

[1-147]

MRPRAVLLLFLMLLPMLPAPPAGQPSGRRRGRRSGGSGGGFWGDRVDSQPFALPYIHPTNPFASDVSTSAGAGARARQAARPLGSAWRDQSQRPSASARR

RPTPAGASPLTAVAPAPDTTPVPDVDSRGAILRRQYNLSTSPLTSTV

[218-226]

TPTSVDMNS

[263-270]

TSGVAEEE

[312-343]

TPGNTNTRVSRYTSTARHRLRRGPDGTAELTT

[432-462]

DLGDSRVTIQDYDNQHEQDRPTPSPAPSRPF

[486-490]

GSTTN

[609-619]

ALEDTADSPAR

[652-660]

MKVGKSREF

38.18

8

147

[1-38]

MRPRAVLLLFLMLLPMLPAPPAGQPSGRRRGRRSGGSG

[70-72]

AGA

[75-117]

RARQAARPLGSAWRDQSQRPSASARRRPTPAGASPLTAVAPAP

[121-122]

PV

[449-458]

QDRPTPSPAP

[604-619]

HAATAALEDTADSPAR

[647-660]

LQRLKMKVGKSREF

18.93

125

43

[1-2]

MR

[13-40]

LLPMLPAPPAGQSSGRRRGRRSGGSGGG

[71-178]

RSGTGLRQSARPLGTAWRDQSQRPPASTRRRSAPSGAAPLTAVAPAPGTAPVPDVDSRGAVLRRQYNLSTSPLTSTVASGTNLVLYAAPLNPLLPLQDGT NTHIMATE

[188-199]

VRATIRYRPLVP

[222-246]

VDMNSITSTDVRIVVQPGLASELVI

[259-290]

RSVETSGVAEEEATSGLVMLCVHGSPVNSYTN

[317-335]

NTRVSRYSSTARHRLKRGA

[396-398]

FYS

[407-413]

EPSVKLY

[425-429]

IAIPH

[445-455]

NQHEQDRPTPS

[457-457]

A

[580-599]

AISTYTTSLGAGPVAISCVG

[660-660]

Y

41.52

14

108

[1-49]

MRPRAILLLLLLLLPMLPAPPAGQSSGRRRGRRSGGSGGGFWGDRVDSQ

[70-142]

SRSGTGLRQSARPLGTAWRDQSQRPPASTRRRSAPSGAAPLTAVAPAPGTAPVPDVDSRGAVLRRQYNLSTSP

[319-340]

RVSRYSSTARHRLKRGADGTAV

[433-461]

LGESRVVIQDYDNQHEQDSRPTPSPAPSRP

26.21

4

73

[1-56]

MRPRAILLLLLLLLPMLPAPPAGQSSGRRRGRRSGGSGGGFWGDRVDSQPFALPYI

[58-147]

PTNPFAADVSAASRSGTGLRQSARPLGTAWRDQSQRPPASTRRRSAPSGAAPLTAVAPAPGTAPVPDVDSRGAVLRRQYNLSTSPLTSTV

[218-226]

TPTSVDMNS

[263-271]

TSGVAEEEA

[313-339]

PGNTNTRVSRYSSTARHRLKRGADGTA

[404-409]

ANGEPS

[433-433]

L

[436-437]

SR

[441-462]

QDYDNQHEQDRPTPSPAPSRPF

[486-491]

GSSTDP

[613-619]

TTDHPAR

[653-660]

KVGKTREY

36.82

12

90

[1-39]

MRPRAILLLLLLLLPMLPAPPAGQSSGRRRGRRSGGSGG

[70-116]

SRSGTGLRQSARPLGTAWRDQSQRPPASTRRRSAPSGAAPLTAVAPA

[448-458]

EQDRPTPSPAP

[606-619]

ALAVLEDTTDHPAR

[647-660]

QRLKMKVGKTREY

18.78

124

46

[19-40]

APPAGQPSGRRRGRRSGGSGGG

[66-129]

ITSSSGAGSRSRQPSRPLGTAWRDQ SQRPAAPTRRRSTPAGAAPLTATAPASGTTPVPDVDSRG

[131-179]

ILRRQYNLSTSPLTSSIASGTNLVLYAAPLSPLLPLQDGTNTHIMATEA

[188-199]

VRATIRYRPLVP

[223-246]

DMNSITSTDVRILVQPGIASELVI

[259-290]

RSVETSGVAEEEATSGLVMLCIHGSPVNSYTN

[318-333]

TRVSRYSSTAHHRLKR

[408-413]

PTVKLY

[425-429]

IAIPH

[445-455]

NQHEQDRPTPS

[457-457]

A

[580-601]

AISTYTTSLGVGPVPISCVGVL

[654-660]

DDDDDDD

41.06

13

64

[1-52]

MCTRAVLLLFLLLLPMLPAPPAGQSGRRRGRRSGGSGGGFWGDRVDSQPFA

[64-139]

ADITSSSGAGSRSRQPSRPLGTAWRDQSQRPAAPTRRRSTPAGAAPLTATAPASGTTPVPDVDSRGAILRRQYNLS

[323-342]

YSSTAHHRLKRGADGTAELT

[434-460]

GESRVVIQDYDNQHEQDRPTPSPAPSR

[657-660]

DDDD

27.12

5

76

[1-148]

MCTRAVLLLFLLLLPMLPAPPAGQSGRRRGRRSGGSGGGFWGDRVDSQPFALPYIHPTNPFVADITSSSGAGSRSRQPSRPLGTAWRDQSQRPAAPTRRRSTPAGAAPLTATAPASGTTPVPDVDSRGAILRRQYNLSTSPLTSSIA

[218-226]

TPTSVDMNS

[263-270]

TSGVAEEE

[314-343]

GNTNTRVSRYSSTAHHRLKRGADGTAELTT

[441-462]

QDYDNQHEQDRPTPSPAPSRPF

[487-490]

STTN

[653-660]

DDDDDDDD

34.70

7

148

[1-40]

MCTRAVLLLFLLLLPMLPAPPAGQPSGRRRGRRSGGSGGG

[70-117]

SGAGSRSRQPSRPLGTAWRDQSQRPAAPTRRRSTPAGAAPLTATAPAS

[121-122]

PV

[449-454]

QDRPTP

[455-457]

PAP

[605-617]

SALAVLEDTIDYPA

[647-660]

IQRLKMKVGKTRES

19.39

128

47