Table 2 Pathways enrichment analysis with their p-value and overlapped genes of common DEGs for CC through three databases including KEGG, Reactome, and WikiPathways. The pathways of the cell cycle are the most significant which have been reported by the three databases
From: Systematic approach to identify therapeutic targets and functional pathways for the cervical cancer
Pathways | p-value | Overlapped genes | Database |
|---|---|---|---|
Cell cycle | 4.92E-16 | 21 | KEGG |
DNA replication | 5.26E-12 | 11 | KEGG |
Cellular senescence | 1.19E-06 | 13 | KEGG |
p53 signaling pathway | 2.13E-06 | 9 | KEGG |
Oocyte meiosis | 6.35E-06 | 11 | KEGG |
Drug metabolism | 8.07E-06 | 10 | KEGG |
Prostate cancer | 2.26E-05 | 9 | KEGG |
Human T-cell leukemia virus 1 infection | 4.70E-05 | 13 | KEGG |
Chemical carcinogenesis | 0.001498 | 11 | KEGG |
Pathways in cancer | 0.002009 | 18 | KEGG |
Cell cycle | 2.40E-39 | 67 | Reactome |
Cell cycle, mitotic | 2.20E-35 | 58 | Reactome |
Mitotic G1-G1/S phases | 1.97E-17 | 23 | Reactome |
S phase | 4.92E-16 | 21 | Reactome |
G1/S transition | 1.22E-14 | 19 | Reactome |
Cell cycle checkpoints | 1.24E-12 | 21 | Reactome |
M phase | 4.93E-11 | 23 | Reactome |
Generic transcription pathway | 0.005002 | 23 | Reactome |
Metabolism | 0.025365 | 41 | Reactome |
Retinoblastoma gene in cancer | 6.87E-28 | 27 | WikiPathways |
G1 to S cell cycle control | 2.42E-15 | 16 | WikiPathways |
Cell cycle | 3.43E-15 | 20 | WikiPathways |
DNA IR-damage and cellular response via ATR | 2.57E-11 | 14 | WikiPathways |
miRNA regulation of DNA damage response | 1.05E-09 | 12 | WikiPathways |
Vitamin D receptor pathway | 3.27E-08 | 16 | WikiPathways |
Integrated breast cancer pathway | 1.52E-04 | 10 | WikiPathways |