Estimating the role of single-nucleotide polymorphism (rs1800629)-308 G/A of TNF-alpha gene as genetic marker associated with angina pectoris in a sample of Iraqi patients

Journal of Genetic Engineering and Biotechnology

Table 4 Genotype and allele frequencies of TNF-alpha gene polymorphism (rs1800629) -308G/A in a stable angina pectoris patients and control groups

Subjects’ groups	TNF-alpha gene SNP at position − 308 (SNP-ID: rs1800629)
	Genotypes			Alleles
	GG	GA	AA	G	A
Control (n = 100)
No	61	28	11	150	50
%	61%	28%	11%	150	50
Stable angina pectoris (n = 100 )
No	28	53	19	109	91
%	28%	53%	19%	109	91
OR	0.2	2.9	1.9	0.40	2.5
EF or PF	PF	AF	AF	PF	AF
95% CI	0.14–0.45	1.62–5.20	0.86–4.21	0.26–0.61	1.64–3.82
P-value	0.004*	0.001*	0.16	0.002*	0.002*

OR, odd ratio; AF, attributable fraction in population; PF, prevented fraction in population; P, Fisher’s exact probability