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Table 2 Levels of serum ALT, AST, creatinine, and urea in the different studied groups administered APAP and/or probiotic LGG

From: Ameliorative effect of Lactobacillus rhamnosus GG on acetaminophen-induced hepatotoxicity via PKC/Nrf2/PGC-1α pathway

Parameters

Vehicle

Probiotic control

Positive control

Prophylactic

Therapeutic

Serum ALT (U/L)

44.75 ± 5.3

47.38 ± 7.61b

82.28 ± 9.2a

46.86 ± 4.1b

61 ± 9.6a,b

Serum AST (U/L)

145.25 ± 7.3

155.13 ± 14.05b

254.8 ± 17.9a

161.25 ± 21.3b

172.5 ± 16.7b

Serum creatinine (mg/dl)

0.26 ± 0.02

0.28 ± 0.05b

0.41 ± 0.04a

0.35 ± 0.05a,b

0.32 ± 0.04a,b

Serum urea (mg/dl)

29 ± 5.61

33.38 ± 3.3b

45.38 ± 4.14a

37.75 ± 4.77a,b

41.2 ± 3.5a

  1. aSignificant difference compared to vehicle group
  2. bSignificant difference compared to positive control