Table 1 Semiquantitative histopathologic scoring in the different studied groups. The H&E stained liver tissue sections were graded using the following scale: ( −) normal, (0/ +) normal or mild, ( +) mild, (+ / + +) mild or moderate (+ +) moderate, and (+ + +) severe
Groups | Blood vessels and sinusoids congestion | Inflammatory cellular infiltrate | Vacuolar degeneration | Parenchymal necrosis | Ductular proliferation | Fibrosis |
|---|---|---|---|---|---|---|
Vehicle | − | − | − | − | − | − |
Probiotic control | + | + | − | − | − | − |
Positive control | + + + | + + + | + + + | + + + | + / + + | + |
Prophylactic | + | + | + | + | − | − |
Therapeutic | + / + + | + + | + / + + | + / + + | − / + | − |