Fig. 1

Multiple response optimization of protease production. Columns represent the effect of each factor on the responses (rows). Vertical red lines represent the optimal values of the independent variables yielding the desired responses. Horizontal blue lines represent the predicted values of responses for the optimal set of independent variables. The numbers in the first row represent the range for each factor and its optimal value (shown in red). Optimal values of responses are shown in the first column (blue values). D is the composite desirability index, encompassing all responses; d is the individual desirability index. (0≤di≤1) higher index values reveal higher desirability, whereas 1 represents a completely desirable