Table 2 Enrichment analysis of modulated proteins by the reported quercetin derivatives

hsa05200

Pathways in cancer

22

517

7.71E−17

KEAP1,HMOX1,RBX1,MMP2,SKP1,TRAF2,RARA,VHL,APC,MDM2,ITGAV,CDH1,AXIN1,CREBBP,EP300,EPAS1,LEF1,NOS2,CTNNB1,CASP8,AR,NFE2L2

hsa04310

Wnt signalling pathway

11

154

5.78E−10

RBX1,TBL1X,SKP1,APC,MMP7,A

IN1,CREBBP,EP300,FBXW11,LEF

CTNNB1

hsa05215

Prostate cancer

9

96

4.52E−09

PLAT,MDM2,CREBBP,EP300,LEF1,

MP3,CTNNB1,PLAU,AR

hsa05132

Salmonella infection

10

209

1.28E−07

TNFRSF1A,RIPK3,TNFRSF10A,SKP1,TNFSF10,TRAF2,RIPK1,LEF1,CTNNB1,CASP8

hsa04066

HIF-1 signaling pathway

8

106

1.83E−07

HMOX1,RBX1,TIMP1,SERPINE1,VHL,CREBBP,EP300,NOS2

hsa05418

Fluid shear stress and atherosclerosis

8

130

6.93E−07

TNFRSF1A,KEAP1,HMOX1,M

P2,PLAT,ITGAV,CTNNB1,NFE

L2

hsa04120

Ubiquitin mediated proteolysis

8

135

7.86E−07

KEAP1,CDC34,RBX1,SKP1,VHL,MDM2,CUL3,FBXW11

hsa04390

Hippo signaling pathway

8

153

1.74E−06

SERPINE1,APC,CDH1,AXIN1,FBXW11,LEF1,CTNNB1,TP73

hsa05165

Human papillomavirus infection

10

325

3.28E−06

TNFRSF1A,VTN,APC,MDM2,ITGAV,AXIN1,CREBBP,EP300,CTNNB1,CASP8

hsa04520

Adherens junction

6

67

4.16E−06

VCL,CDH1,CREBBP,EP300,LEF1,CTNNB1

hsa04115

p53 signaling pathway

6

72

5.65E−06

TNFRSF10A,SERPINE1,MDM2,CASP8,TP73,CHEK1

hsa05170

Human immunodeficiency virus 1 infection

8

204

9.71E−06

TNFRSF1A,RBX1,SKP1,TRAF2,RIPK1,FBXW11,CASP8,CHEK1

hsa05131

Shigellosis

8

218

1.46E−05

TNFRSF1A,VCL,RBX1,SKP1,TRAF2,MDM2,RIPK1,FBXW11

hsa04217

Necroptosis

7

149

1.54E−05

TNFRSF1A,RIPK3,TNFRSF10A,TNFSF10,TRAF2,RIPK1,CASP8

hsa05206

MicroRNAs in cancer

7

160

2.28E−05

SIRT1,HMOX1,APC,MDM2,CREBBP,EP300,PLAU

hsa05225

Hepatocellular carcinoma

7

160

2.28E−05

KEAP1,HMOX1,APC,AXIN1,LEF1,CTNNB1,NFE2L2

hsa05213

Endometrial cancer

5

57

3.41E−05

APC,CDH1,AXIN1,LEF1,CTNNB1

hsa04668

TNF signaling pathway

6

112

4.03E−05

TNFRSF1A,RIPK3,TRAF2,RIPK1,MMP3,CASP8

hsa05167

Kaposi sarcoma-associated herpesvirus infection

7

187

4.90E−05

TNFRSF1A,TRAF2,CREBBP,EP300,LEF1,CTNNB1,CASP8

hsa04110

Cell cycle

6

120

5.32E−05

RBX1,SKP1,MDM2,CREBBP,EP300,CHEK1

hsa05211

Renal cell carcinoma

5

66

5.43E−05

RBX1,VHL,CREBBP,EP300,EPAS1

hsa04068

FoxO signaling pathway

6

127

6.62E−05

SIRT1,CAT,TNFSF10,MDM2,CREBBP,EP300

hsa04210

Apoptosis

6

132

7.84E−05

TNFRSF1A,TNFRSF10A,TNFSF10,TRAF2,RIPK1,CASP8

hsa05163

Human cytomegalovirus infection

7

218

0.0001

TNFRSF1A,TRAF2,MDM2,RIPK1,ITGAV,CTNNB1,CASP8

hsa05010

Alzheimer disease

8

355

0.00025

TNFRSF1A,LRP1,TRAF2,APC,AXIN1,NOS2,CTNNB1,CASP8

hsa05152

Tuberculosis

6

168

0.00025

TNFRSF1A,CREBBP,EP300,NOS2,CASP8,VDR

hsa05164

Influenza A

6

165

0.00025

TNFRSF1A,TNFRSF10A,TNFSF10,CREBBP,EP300,CASP8

hsa05203

Viral carcinogenesis

6

182

0.00038

TRAF2,MDM2,CREBBP,EP300,CASP8,CHEK1

hsa05130

Pathogenic Escherichia coli infection

6

187

0.00042

TNFRSF1A,TNFRSF10A,TNFSF10,TRAF2,RIPK1,CASP8

hsa05205

Proteoglycans in cancer

6

196

0.00053

MMP2,VTN,MDM2,ITGAV,CTNNB1,PLAU

hsa04919

Thyroid hormone signaling pathway

5

119

0.00056

MDM2,ITGAV,CREBBP,EP300,CTNNB1

hsa04114

Oocyte meiosis

5

120

0.00057

RBX1,SKP1,FBXW11,PGR,AR

hsa05217

Basal cell carcinoma

4

62

0.00068

APC,AXIN1,LEF1,CTNNB1

hsa04371

Apelin signaling pathway

5

131

0.0008

PLAT,SERPINE1,CDH1,PPARGC1A,NOS2

hsa05224

Breast cancer

5

145

0.0012

APC,AXIN1,LEF1,PGR,CTNNB1

hsa05226

Gastric cancer

5

144

0.0012

APC,CDH1,AXIN1,LEF1,CTNNB1

hsa04218

Cellular senescence

5

150

0.0014

SIRT1,SERPINE1,MDM2,FBXW11,CHEK1

hsa04610

Complement and coagulation cascades

4

82

0.0016

PLAT,SERPINE1,VTN,PLAU

hsa04710

Circadian rhythm

3

30

0.0016

RBX1,SKP1,FBXW11

hsa05160

Hepatitis C

5

156

0.0016

TNFRSF1A,TRAF2,RIPK1,CTNNB1,CASP8

hsa05210

Colorectal cancer

4

82

0.0016

APC,AXIN1,LEF1,CTNNB1

hsa04350

TGF-beta signaling pathway

4

91

0.0022

RBX1,SKP1,CREBBP,EP300

hsa05202

Transcriptional misregulation in cancer

5

171

0.0022

PLAT,RARA,MDM2,MMP3,PLAU

hsa04916

Melanogenesis

4

95

0.0024

CREBBP,EP300,LEF1,CTNNB1

hsa05216

Thyroid cancer

3

36

0.0024

CDH1,LEF1,CTNNB1

hsa05142

Chagas disease

4

99

0.0027

TNFRSF1A,SERPINE1,NOS2,CASP8

hsa04064

NF-kappa B signaling pathway

4

101

0.0029

TNFRSF1A,TRAF2,RIPK1,PLAU

hsa04922

Glucagon signaling pathway

4

101

0.0029

SIRT1,CREBBP,EP300,PPARGC1A

hsa05016

Huntington disease

6

298

0.0030

TRAF2,CREBBP,EP300,PPARGC1A,CASP8,GPX1

hsa05219

Bladder cancer

3

41

0.0030

MMP2,MDM2,CDH1

hsa05166

Human T-cell leukemia virus 1 infection

5

211

0.0046

TNFRSF1A,MMP7,CREBBP,EP300,CHEK1

hsa04934

Cushing syndrome

4

153

0.0118

APC,AXIN1,LEF1,CTNNB1

hsa04920

Adipocytokine signaling pathway

3

69

0.0119

TNFRSF1A,TRAF2,PPARGC1A

hsa04622

RIG-I-like receptor signaling pathway

3

70

0.0122

TRAF2,RIPK1,CASP8

hsa05100

Bacterial invasion of epithelial cells

3

70

0.0122

VCL,CDH1,CTNNB1

hsa04141

Protein processing in endoplasmic reticulum

4

165

0.0144

RBX1,SKP1,TRAF2,NFE2L2

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

3

76

0.0145

ITGAV,LEF1,CTNNB1

hsa04621

NOD-like receptor signaling pathway

4

174

0.0168

RIPK3,TRAF2,RIPK1,CASP8

hsa04211

Longevity regulating pathway

3

87

0.0203

SIRT1,CAT,PPARGC1A

hsa04657

IL-17 signaling pathway

3

92

0.0233

TRAF2,MMP3,CASP8

hsa05169

Epstein-Barr virus infection

4

193

0.0233

TRAF2,MDM2,RIPK1,CASP8

hsa05222

Small cell lung cancer

3

92

0.0233

TRAF2,ITGAV,NOS2

hsa04510

Focal adhesion

4

198

0.0244

VCL,VTN,ITGAV,CTNNB1

hsa04061

Viral protein interaction with cytokine and cytokine receptor

3

96

0.0245

TNFRSF1A,TNFRSF10A,TNFSF10

hsa04215

Apoptosis - multiple species

2

30

0.0300

TNFRSF1A,CASP8

hsa05145

Toxoplasmosis

3

105

0.0304

TNFRSF1A,NOS2,CASP8

hsa05014

Amyotrophic lateral sclerosis

5

352

0.0316

TNFRSF1A,CAT,TRAF2,NOS2,GPX1

hsa04670

Leukocyte transendothelial migration

3

109

0.0326

VCL,MMP2,CTNNB1