Skip to main content
Journal of Genetic Engineering and Biotechnology
Fig. 3 | Journal of Genetic Engineering and Biotechnology

Fig. 3

From: Single nucleotide variants of receptor for advanced glycation end-products (AGER) gene: is it a new opening in the risk assessment of diabetic retinopathy?—a review

Fig. 3

Receptor for AGE interacts not only with AGEs but also with other ligands like LPA, CD11, calgranulins, amyloid beta, HGMB1, and S100 protein. The interaction of AGEs with AGER initiates a downstream signalling cascade. The primary mediator for the inflammatory pathway is the ultimate induction of NFkB, which causes oxidative and inflammatory damage. Hyperglycemia associated oxidative ER stress and reactive oxygen species production induce NFkB. This inflammatory and oxidative damage thus caused creates a positive feedback loop causing further AGER activation

Back to article page