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Table 2 Determination of succinate dehydrogenase (SDH) and coenzyme Q reductase (complex II) activities by IC50

From: Study of the inhibitory effects of chrysin and its nanoparticles on mitochondrial complex II subunit activities in normal mouse liver and human fibroblasts

Relative enzyme activity %

Negative control (untreated cells)

Chrysin

Mean± SEM

*p value

CNPs

Mean± SEM

*p value

CCNPs

Mean± SEM

*p value

5-Fluorouracil

Mean± SEM

*p value

Succinate dehydrogenase by MTT test

100 ± 0

40.14±0.03

P <0.0001

90.9± 0.005

P <0.0001

86.7±0.041

P <0.0001

89± 0.02

P <0.0001

Ubiquinone reductase by DCPI dye

100 ± 0

70.90±0.003

P <0.0001

86.74 ± 0.005

P <0.0001

60.8 ±0.002

P <0.0001

80.23 ±0.02

P < 0.0001

  1. *p value versus the negative control (untreated cells)