Journal of Genetic Engineering and Biotechnology

Table 2 Diagnostic power of investigated biomarkers and model for differentiating liver cirrhosis vs. HCC

From: A novel model based on interleukin 6 and insulin-like growth factor II for detection of hepatocellular carcinoma associated with hepatitis C virus

Markers	AUC (95% Cl)	Cut-off	Sensitivity	Specificity	PPV	NPV	Accuracy
IGF2	0.86 (0.78-0.94)	10	80	73.3	80	73	77
IL6	0.82 (0.66-0.89)	13.5	72	70	73.5	75	74.2
AFP	0.72 (0.65-0.8)	400	27	100	100	35	48
PLT	0.6 (0.51-0.96)	95	65	52	71	78	60
^aModel	0.97 (0.92-1)	1.28	90	85	82	92	87

^aA four-marker model (IGF2 + IL6 + AFP + PLT)

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