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Table 2 Diagnostic power of investigated biomarkers and model for differentiating  liver cirrhosis vs. HCC

From: A novel model based on interleukin 6 and insulin-like growth factor II for detection of hepatocellular carcinoma associated with hepatitis C virus

Markers AUC (95% Cl) Cut-off Sensitivity Specificity PPV NPV Accuracy
IGF2 0.86 (0.78-0.94) 10 80 73.3 80 73 77
IL6 0.82 (0.66-0.89) 13.5 72 70 73.5 75 74.2
AFP 0.72 (0.65-0.8) 400 27 100 100 35 48
PLT 0.6 (0.51-0.96) 95 65 52 71 78 60
aModel 0.97 (0.92-1) 1.28 90 85 82 92 87
  1. aA four-marker model (IGF2 + IL6 + AFP + PLT)