Fig. 1
From: Role of “dual-personality” fragments in HEV adaptation—analysis of Y-domain region
Diagrammatic representation of hepatitis E virus nonstructural polyprotein (ORF1) domain, showing the Y-domain. The ORF1 constitutes seven domains, i.e., MTase, methyltransferase; Y, undefined; PCP, papain-like cysteine protease; P/HVR, proline-rich/hypervariable region; X, Macro; Hel/NTPase, helicase/nucleotide triphosphatase; and RdRp, RNA-dependent RNA polymerase. The Y-domain region (YDR) is of 228 amino acids in length (650–1339 nucleotides) and consists of a potential palmitoylation site (C336C337) and an alpha-helix segment (L410Y411S412W413L414F415E416). These segments are found to be indispensable for cytoplasmic membrane binding and are highly conserved within HEV genotypes