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Table 6 Relation of TLR4 genotypes versus demographic, clinical, and outcome data in vitiligo group 2 (above 18 years) patients

From: TLR4 gene polymorphisms in Egyptian vitiligo patients: insights into emerging association with clinical activity, family history, and response to therapy

SNPs

RS1927914

RS1927911

RS11536858

CC

N/%

CT

N/%

TT

N/%

CC

N/%

CT

N/%

TT

N/%

AA

N/%

AG

N/%

GG

N/%

Sex

M/F

0.12/0.13

0.21/0.17

0.67/0.71

0.27/0.22

0.58/0.60

0.15/0.18

0.24/0.26

0.60/0.59

0.17/0.14

P

0.88

0.47

0.61

0.49

0.79

0.64

0.68

0.97

0.65

Course

Regressive/Progressive/stable

0.40/0.13/0.25

0.00/0.10/0.25

0.60/0.76/0.50

0.40/0.15/0.25

0.60/0.67/0.50

0.00/0.18/0.25

0.20/0.25/0.25

0.60/0.59/0.50

0.20/0.15/0.25

p

0.25

0.48

0.39

0.33

0.75

0.54

0.97

0.93

0.84

Psychiatric trauma

+/−

0.09/0.30

0.08/0.11

0.61/0.79

0.09/0.21

0.74/0.62

0.17/0.17

0.17/0.28

0.70/0.55

0.13/0.17

p

0.02

1.0

0.09

0.32

0.33

1.0

0.39

0.22

1.0

Alopecia

+/−

0.23/0.14

0.15/0.09

0.39/0.24

0.00/0.21

0.92/0.60

0.08/0.19

0.31/0.24

0.46/0.62

3/23.1

p

0.42

0.62

0.28

0.11

0.03

0.45

0.73

0.29

0.42

FH of vitiligo

+/−

0.00/0.17

0.00/0.11

1.00/0.72

0.00/0.18

0.50/0.67

0.50/0.15

0.25/0.25

0.25/0.61

0.50/0.14

p

1.0

1.0

0.57

1.0

0.60

0.13

1.0

0.29

0.12

FHAIDs

+/−

0.14/0.16

0.14/0.10

0.71/0.74

0.14/0.17

0.71/0.65

0.14/0.17

0.29/0.25

0.71/0.58

0.00/0.17

p

1.0

0.56

0.89

1.0

0.74

1.0

1.0

0.49

0.59

Remission

+/−

0.18/0.10

0.09/0.15

0.73/0.75

0.18/0.15

0.63/0.75

0.20/0.10

0.23/0.30

0.64/0.45

0.13/0.25

p

0.50

0.43

0.88

1.0

0.31

0.49

0.55

0.13

0.19

Type

Segmental/Nonsegmental

0.00/0.19

0.23/0.08

0.78/0.73

0.00/0.21

0.77/0.64

0.23/0.16

0.31/0.24

0.54/0.60

0.15/0.16

p

0.11

0.13

0.77

0.11

0.35

0.69

0.73

0.67

1.0

  1. M/F male/female, R/P regressive/progressive, Seg/Nonseg segmental/nonsegmental, FH family history, FHAIDs family history of auto-immune diseases, p value significant if < 0.05
  2. Fischer exact test
  3. Significant p value for the association between the CC genotype of rs1927914 and psychiatric trauma and between the CT genotype of rs1927911 and alopecia