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Table 6 Relation of TLR4 genotypes versus demographic, clinical, and outcome data in vitiligo group 2 (above 18 years) patients

From: TLR4 gene polymorphisms in Egyptian vitiligo patients: insights into emerging association with clinical activity, family history, and response to therapy

SNPs RS1927914 RS1927911 RS11536858
CC
N/%
CT
N/%
TT
N/%
CC
N/%
CT
N/%
TT
N/%
AA
N/%
AG
N/%
GG
N/%
Sex M/F 0.12/0.13 0.21/0.17 0.67/0.71 0.27/0.22 0.58/0.60 0.15/0.18 0.24/0.26 0.60/0.59 0.17/0.14
P 0.88 0.47 0.61 0.49 0.79 0.64 0.68 0.97 0.65
Course Regressive/Progressive/stable 0.40/0.13/0.25 0.00/0.10/0.25 0.60/0.76/0.50 0.40/0.15/0.25 0.60/0.67/0.50 0.00/0.18/0.25 0.20/0.25/0.25 0.60/0.59/0.50 0.20/0.15/0.25
p 0.25 0.48 0.39 0.33 0.75 0.54 0.97 0.93 0.84
Psychiatric trauma +/− 0.09/0.30 0.08/0.11 0.61/0.79 0.09/0.21 0.74/0.62 0.17/0.17 0.17/0.28 0.70/0.55 0.13/0.17
p 0.02 1.0 0.09 0.32 0.33 1.0 0.39 0.22 1.0
Alopecia +/− 0.23/0.14 0.15/0.09 0.39/0.24 0.00/0.21 0.92/0.60 0.08/0.19 0.31/0.24 0.46/0.62 3/23.1
p 0.42 0.62 0.28 0.11 0.03 0.45 0.73 0.29 0.42
FH of vitiligo +/− 0.00/0.17 0.00/0.11 1.00/0.72 0.00/0.18 0.50/0.67 0.50/0.15 0.25/0.25 0.25/0.61 0.50/0.14
p 1.0 1.0 0.57 1.0 0.60 0.13 1.0 0.29 0.12
FHAIDs +/− 0.14/0.16 0.14/0.10 0.71/0.74 0.14/0.17 0.71/0.65 0.14/0.17 0.29/0.25 0.71/0.58 0.00/0.17
p 1.0 0.56 0.89 1.0 0.74 1.0 1.0 0.49 0.59
Remission +/− 0.18/0.10 0.09/0.15 0.73/0.75 0.18/0.15 0.63/0.75 0.20/0.10 0.23/0.30 0.64/0.45 0.13/0.25
p 0.50 0.43 0.88 1.0 0.31 0.49 0.55 0.13 0.19
Type Segmental/Nonsegmental 0.00/0.19 0.23/0.08 0.78/0.73 0.00/0.21 0.77/0.64 0.23/0.16 0.31/0.24 0.54/0.60 0.15/0.16
p 0.11 0.13 0.77 0.11 0.35 0.69 0.73 0.67 1.0
  1. M/F male/female, R/P regressive/progressive, Seg/Nonseg segmental/nonsegmental, FH family history, FHAIDs family history of auto-immune diseases, p value significant if < 0.05
  2. Fischer exact test
  3. Significant p value for the association between the CC genotype of rs1927914 and psychiatric trauma and between the CT genotype of rs1927911 and alopecia