Andrographolide binds to spike glycoprotein and RNA-dependent RNA polymerase (NSP12) of SARS-CoV-2 by in silico approach: a probable molecule in the development of anti-coronaviral drug

Journal of Genetic Engineering and Biotechnology

Table 2 Docking scores of andrographolide with SARS-CoV-2 spike RBD and with RNA-dependent RNA polymerase of SARS-CoV-2

	Dock score	H-bonds	Interacting residues	H-bond length	H-bond score
Spike RBD	−10.3460	3	ASP 405	2.4 Å	34%
			ARG 408	2.8 Å	94%
			TYR 453	3.0 Å	19%
RdRP	−10.7313	4	THR 556	2.7 Å	15%
			THR 556	2.6 Å	46%
			THR 556	2.7 Å	88%
			THR 556	2.5 Å	76%