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Journal of Genetic Engineering and Biotechnology
Fig. 11 | Journal of Genetic Engineering and Biotechnology

Fig. 11

From: Gene network analysis to determine the effect of hypoxia-associated genes on brain damages and tumorigenesis using an avian model

Fig. 11

Gene network analysis for the identification of roles of key candidate genes in breast cancer. Our gene network analysis indicated that two protein transporters including APOB (Apolipoprotein B) and CLCA2 genes are involved in breast cancer. APOB is one important member of body’s lipid profile and is considered as an essential factor for cholesterol hemostasis. The abnormal level of APOB is associated with different diseases including cardiovascular, inflammation, and tumorigenesis. Furthermore, it was reported that rs693 and rs1042031 polymorphisms that existed in the APOB gene increased the risk of breast cancer. Another result showed that CLCA2 is involved in the calcium-activated chloride channel regulator family and regulates transferring the chloride across the plasma membrane. The over-expression of the CLCA2 gene in negative cell lines of CLCA2 will lead to the reduction of metastasis and tumorigenesis

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