Analgesic and anti-inflammatory potential of Lupeol isolated from Indian traditional medicinal plant Crateva adansonii screened through in vivo and in silico approaches

Journal of Genetic Engineering and Biotechnology

Table 1 Acute anti-inflammatory activity of Crateva adansonii leaf extracts and its Lupeol containing LF in male Wistar albino rat

Groups	Drug Treatment	Paw thickness in mm							% Inhibition at 3 h
Groups	Drug Treatment	0 h	½ h	1 h	1½ h	2 h	2½ h	3 h	% Inhibition at 3 h
I	Control 0.1% CMC	1.8 ± 0.02	3.6 ± 0.02	5.2 ± 0.04	6.2 ± 0.02	5.4 ± 0.02	4.8 ± 0.02	4.1 ± 0.02	-
II	Indomethacin 20 mg/kg	1.6 ± 0.04	2.4 ± 0.04**	2.9 ± 0.01**	3.2 ± 0.01**	2.8 ± 0.01**	2.5 ± 0.04**	2.0 ± 0.01*	48
III	ME 200 mg/kg	1.1 ± 0.02	2.8 ± 0.04**	3.2 ± 0.04**	3.6 ± 0.04**	3.3 ± 0.02**	2.9 ± 0.02*	2.5 ± 0.01**	42
IV	ME 400 mg/kg	1.4 ± 0.04	2.6 ± 0.01**	3.1 ± 0.01**	3.4 ± 0.03**	3.0 ± 0.01**	2.6 ± 0.01**	2.2 ± 0.01**	45
V	CE 200 mg/kg	1.4 ± 0.02	3.4 ± 0.01*	4.0 ± 0.02**	4.4 ± 0.04**	3.6 ± 0.02**	3.1 ± 0.02**	2.6 ± 0.03**	29
VI	CE 400 mg/kg	1.2 ± 0.01	2.9 ± 0.02**	3.4 ± 0.02*	3.8 ± 0.02**	3.2 ± 0.04**	2.9 ± 0.04**	2.5 ± 0.02*	39
VII	LF 100 mg/kg	1.5 ± 0.03	3.0 ± 0.03**	3.1 ± 0.01**	3.1 ± 0.01**	2.7 ± 0.01**	2.2 ± 0.02**	1.8 ± 0.03**	50

The data are presented as mean ± SEM, n = 6, *p < 0.05, **p < 0.01 vs. control. Data were analyzed by using one-way ANOVA followed by Dunnett’s “t” test using the software Graph Pad
ME Methanolic extract of C. adansonii leaf, CE Chloroform extract of C. adansonii leaf, LF Lupeol fraction