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Table 1 Acute anti-inflammatory activity of Crateva adansonii leaf extracts and its Lupeol containing LF in male Wistar albino rat

From: Analgesic and anti-inflammatory potential of Lupeol isolated from Indian traditional medicinal plant Crateva adansonii screened through in vivo and in silico approaches

Groups Drug Treatment Paw thickness in mm % Inhibition at 3 h
0 h ½ h 1 h 1½ h 2 h 2½ h 3 h
I Control 0.1% CMC 1.8 ± 0.02 3.6 ± 0.02 5.2 ± 0.04 6.2 ± 0.02 5.4 ± 0.02 4.8 ± 0.02 4.1 ± 0.02 -
II Indomethacin 20 mg/kg 1.6 ± 0.04 2.4 ± 0.04** 2.9 ± 0.01** 3.2 ± 0.01** 2.8 ± 0.01** 2.5 ± 0.04** 2.0 ± 0.01* 48
III ME 200 mg/kg 1.1 ± 0.02 2.8 ± 0.04** 3.2 ± 0.04** 3.6 ± 0.04** 3.3 ± 0.02** 2.9 ± 0.02* 2.5 ± 0.01** 42
IV ME 400 mg/kg 1.4 ± 0.04 2.6 ± 0.01** 3.1 ± 0.01** 3.4 ± 0.03** 3.0 ± 0.01** 2.6 ± 0.01** 2.2 ± 0.01** 45
V CE 200 mg/kg 1.4 ± 0.02 3.4 ± 0.01* 4.0 ± 0.02** 4.4 ± 0.04** 3.6 ± 0.02** 3.1 ± 0.02** 2.6 ± 0.03** 29
VI CE 400 mg/kg 1.2 ± 0.01 2.9 ± 0.02** 3.4 ± 0.02* 3.8 ± 0.02** 3.2 ± 0.04** 2.9 ± 0.04** 2.5 ± 0.02* 39
VII LF 100 mg/kg 1.5 ± 0.03 3.0 ± 0.03** 3.1 ± 0.01** 3.1 ± 0.01** 2.7 ± 0.01** 2.2 ± 0.02** 1.8 ± 0.03** 50
  1. The data are presented as mean ± SEM, n = 6, *p < 0.05, **p < 0.01 vs. control. Data were analyzed by using one-way ANOVA followed by Dunnett’s “t” test using the software Graph Pad
  2. ME Methanolic extract of C. adansonii leaf, CE Chloroform extract of C. adansonii leaf, LF Lupeol fraction