Association of some dietary ingredients, vitamin D, estrogen, and obesity polymorphic receptor genes with bone mineral density in a sample of obese Egyptian women

Hassan, Nayera E.; El Shebini, Salwa M.; El-Masry, Sahar A.; Ahmed, Nihad H.; Eldeen, Ghada Nour; Rasheed, Enas A.; Aly, Manal M.; Alian, Khhadija M.; Afify, Mahmoud A S.; Khalil, Aya

doi:10.1186/s43141-021-00127-0

Journal of Genetic Engineering and Biotechnology

Table 4 Comparison between different studied obesity receptors genes genotypes regarding the related investigated parameters

From: Association of some dietary ingredients, vitamin D, estrogen, and obesity polymorphic receptor genes with bone mineral density in a sample of obese Egyptian women

Parameters N = 97	Non-osteoporotics N = 45				Osteoporotic N = 52
FTOrs99 obesity receptor	Homozygous No: 27	Heterozygous No: 16	Mutant No: 2	P	Homozygous No: 30	Heterozygous No: 17	Mutant No: 5	P
FTOrs99 obesity receptor	Mean ± SD	Mean ± SD	Mean ± SD	P	Mean ± SD	Mean ± SD	Mean ± SD	P
Age (years)	36.65 ± 8.01#	41.75 ± 7.17	38.63 ± 9.75	0.134	55.20 ± 4.68#	51.93 ± 5.91┼	57.92 ± 3.77	0.040*
Weight (kg)	74.12 ± 2.71	87.61 ± 1.53	77.00 ± 3.47	0.183	79.82 ± 1.57	74.11 ± 1.79	85.32 ± 1.63	0.283
Height (cm)	157.30 ± 6.01	157.19 ± 4.32	150.50 ± 9.19	0.234	155.17 ± 5.52	155.18 ± 6.85┼	146.80 ± 9.44@	0.027*
BMI (kg/m²⁾	29.77 ± 9.67#	35.38 ± 5.54	33.24 ± 3.12	0.120	33.18 ± 6.44	30.62 ± 6.88┼	40.83 ± 5.38@	0.034*
Caloric intake (Cal)	1655.93 ± 28.75#	2483.73 ± 26.19	2150.64 ± 8.76	0.007**	2684.63 ± 37.69#	2711.63 ± 31.15	2720.13 ± 39.54	0.030*
Fat intake (g)	85.71 ± 2.97	90.55 ± 8.26	114.18 ± 13.61	0.554	132.38 ± 15.54#	134.25 ± 13.34	135.14 ± 14.50	0.017*
SFAs (g)	25.57 ± 16.01#	32.88 ± 12.95	37.21 ± 8.70	0.002**	44.67 ± 17.21#	46.14 ± 15.82	47.30 ± 15.46	0.014*
MUSFAs (g)	18.73 ± 16.02#	20.34 ± 13.78	20.96 ± 2.78	0.005**	32.75 ± 16.12#	31.72 ± 20.04	31.36 ± 14.69	0.114
PUSFAs (g)	18.83 ± 18.45#	21.85 ± 13.41	20.44 ± 14.74	0.072	30.23 ± 18.48	31.64 ± 8.95	29.63 ± 15.04	0.329
FTOrs80 obesity receptor	Homozygous No: 27	Heterozygous No: 16	Mutant No: 2	P	Homozygous No: 24	Heterozygous No: 22	Mutant No: 6	P
FTOrs80 obesity receptor	Mean ± SD	Mean ± SD	Mean ± SD	P	Mean ± SD	Mean ± SD	Mean ± SD	P
Age (years)	36.65 ± 8.015#	41.75 ± 7.17#	38.63 ± 9.75	0.134	55.28 ± 4.86	52.48 ± 5.62┼	57.84 ± 3.38^*	0.051
Weight (kg)	74.12 ± 2.71	87.61 ± 1.53	77.00 ± 3.47	0183	77.15 ± 1.57	77.58 ± 1.78	87.13 ± 1.52	0.389
Height (cm)	157.30 ± 6.01	157.19 ± 4.32	150.50 ± 9.19	0.234	154.46 ± 5.47	156.09 ± 6.57┼	147.67 ± 8.71@	0.027*
BMI (k/m²⁾	29.77 ± 9.67#	35.38 ± 5.54#	33.24 ± 2.12	0.120	32.40 ± 6.66	31.67 ± 6.60┼	40.96 ± 4.23^@	0.027*
Caloric intake (Cal)	1655.93 ± 28.75#	2483.76 ± 26.19#	2450.65 ± 28.76	0.007**	2265.28 ± 29.75	2625.97 ± 28.69	2711.85 ± 26.91^*	0.314
Fat intake (g)	90.55 ± 8.26	114.18 ± 3.61	118.71 ± 2.97	0.554	120.43 ± 4.86	129.79 ± 5.97	131.90 ± 3.31	0.137
SFAs (g)	20.57 ± 16.01#	36.88 ± 12.95#	38.21 ± 8.70	0.002**	36.14 ± 16.98	44.46 ± 18.47	46.76 ± 14.23^*	0.182
MUSFAs (g)	18.73 ± 6.02#	25.34 ± 13.78#	25.96 ± 10.78	0.005**	26.84 ± 11.02	30.12 ± 11.13	29.69 ± 10.70^*	0.481
PUSFAs (g)	18.83 ± 4.45#	21.85 ± 10.#41	22.44 ± 11.74	0.072	24.37 ± 10.72	29.58 ± 11.14	25.06 ± 7.24^*	0.491

BMI body mass index, SFAs saturated fatty acids, MUSFAs mono unsaturated fatty acids, PUSFAs poly unsaturated fatty acids
^#Significant differences between homo and hetero
^┼Significant differences between hetero and mutant
^@Significant differences between mutant and homo

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