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Table 6 Cytotoxic activity of designed compounds

From: In silico design and molecular docking study of CDK2 inhibitors with potent cytotoxic activity against HCT116 colorectal cancer cell line

Compound R1 R2 R3 pIC50 (M) IC50 (μM)
a. -H -Br -H 5.1581 6.9490
b. -H -NO2 -H 5.2999 5.0131
c. -F -H -H 5.3681 4.2843
d. -Cl -H -H 5.1022 7.9040
e. -F -H -F 5.4049 3.9362
f. -Cl -H -Cl 4.9666 10.7985
g. -Br -Br -H 5.1224 7.5440
h. -F -F -H 5.8668 1.3590
i. -Cl -Cl -H 4.9438 11.3808
j. -NO2 -H -H 5.478 3.3265
k. -Br -H -Br 5.1535 7.0224
l. -NO2 -H -NO2 5.7351 1.8403
Template (compound 20) -Br -H -H 5.257 5.5330
Doxorubicina      5.23 ± 0.2
  1. Key: a Abo-Elanwar et al. [16]