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Table 3 Some genes upregulated by cold stress in S. cerevisiae and mammalian cells

From: The potential of cold-shock promoters for the expression of recombinant proteins in microbes and mammalian cells

Gene

Description

Temperature downshift

Reference

Yeast: Saccharomyces cerevisiae

 TIP1

Temperature shock inducible protein

30 to 10 °C

[121]

 NSR1

Protein involved in ribosomal biogenesis and cell growth

30 to 10 °C

[118]

 TIR1, TIR2

Serine-rich stress proteins

30 to 10 °C

[122]

 BFR2

Protein involved in secretion

30 to 10 °C

[123]

 TPS1, TPS2, HSP104

Trehalose-synthesizing enzymes, 104 kDa heat shock protein

30 to 4 °C and 30 to 0 °C

[22]

 OLE1

Stearoyl-CoA 9-desaturase

30 to 10 °C

[124]

 TPI1, ERG10, IMH1

Triose-phosphate isomerase, acetoacetyl coenzyme A thiolase, protein implicated in protein transport, respectively

30 to 10 °C and 30 to – 20 °C

[125]

 GPD1

Main enzyme for glycerol production

30 to 4 °C

[126]

 HSP12, HSP26

26 kDa heat shock protein

30 to 10 °C

[15]

 GLC3, GAC1

Glycogen biosynthesis

25 to 4 °C

[127]

 CCTα, CCTβ

chaperonin containing the T-complex polypeptide–1 [TCP1] α and β subunits

30 to 4 °C

[119]

 HSF1, SSE2

Heat shock transcription factor, HSP70 family member

30 to 4 °C

[128]

Mammalian cells

 CIRP

Cold-inducible RNA-binding protein

37 to 32 °C

[80]

 RBM3

RNA-binding motif protein 3

37 to 32 °C

[129]

 HSP72, HSP90

72 kDa heat shock protein, 90 kDa heat shock protein

37 to 4 °C and 37 to 15 °C

[130]

 WAF1

A cyclin-dependent kinase inhibitor

37 to 4 °C

[131]