Estimating the role of single-nucleotide polymorphism (rs1800629)-308 G/A of TNF-alpha gene as genetic marker associated with angina pectoris in a sample of Iraqi patients

Journal of Genetic Engineering and Biotechnology

Table 5 Genotype and allele frequencies of TNF-alpha gene polymorphism (rs1800629) -308G/A in unstable angina pectoris patients and control groups

Subjects’ groups	TNF-alpha gene SNP at position − 308 (SNP-ID: rs1800629)
	Genotypes			Alleles
	GG	GA	AA	G	A
Control (n = 100)
No	61	28	11	150	50
%	61%	28%	11%	150	50
Unstable angina pectoris (n = 100)
No	30	33	37	93	107
%	30%	33%	37%	93	107
OR	0.27	1.7	4.7	0.29	3.45
EF or PF	PF	AF	AF	PF	AF
95% CI	0.15–0.49	0.69–2.31	2.26–9.99	0.19–0.44	2.26–5.27
P-value	0.001	0.53	0.002	0.000	0.000

OR, odd ratio; AF, attributable fraction in population; PF, prevented fraction in population; P, Fisher’s exact probability