Estimating the role of single-nucleotide polymorphism (rs1800629)-308 G/A of TNF-alpha gene as genetic marker associated with angina pectoris in a sample of Iraqi patients

Journal of Genetic Engineering and Biotechnology

Table 3 Genetic inheritance model genotypes and the association for allele frequency of TNF-alpha gene polymorphism (rs1800629) − 308G/Ain angina pectoris patients and control groups

Genetic model	Genotype of rs1800629 SNP	AP patients (N = 2 00)	Heathy control (N = 100)	OR: (CI: 95%)	p-value
Codominant	GG	58	61	Ref	-
	GA	86	28	1.94 (1.16–3.25)	0.012*
	AA	56	11	3.15 (1.57–6.31)	0.001*
Dominant	GG	58	61	Ref
Dominant	GA/AA	142	39	3.83 (2.32–6.33)	0.000*
Recessive	GA/GG	144	89	Ref
Recessive	AA	56	11	3.15 (1.57–6.31)	0.001*
Over dominant	GG/AA	114	72	Ref
Over dominant	GA	86	28	1.94 (1.16–3.25)	0.001*
Allele	G	202	150	Ref
Allele	A	198	50	2.94 (2.02–4.28)	0.000*

P-value ≤ 0.05, OR, odd ratio; CI 95% confidence interval; *significant difference; ref, reference